Abstract
This systematic review sought to investigate the current evidence regarding surgical management of primary cardiac tumors in children. Twenty-four studies were deemed eligible, reporting on 713 pediatric patients. Cumulative 30-day mortality rate was 5.5% and 7.5% after surgery. It was revealed a statistically lower mortality rate in the group of patients below 1 year of age, justifying a more aggressive surgical approach for primary cardiac tumors, except for rhabdomyoma that can regress spontaneously.
Similar content being viewed by others
References
Maurer ER (1952) Successful removal of tumors of the heart. J Thorac Surg 23:479–485
Taber RE, Lam CR (1960) Diagnosis and surgical treatment of intra-cardiac myxoma and rhabdomyoma. J Thorac Cardiovasc Surg 40:337
Tzani A, Doulamis IP, Mylonas KS, Avgerinos DV, Nasioudis D (2017) Cardiac tumors in pediatric patients: a systematic review. World J Pediatr Congenit Heart Surg 8(5):624–632
Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JPA, Clarke M, Devereaux PJ, Kleijnen J, Moher D (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 339:b2700. https://doi.org/10.1136/bmj.b2700
Page MJ, McKenzie JE, Bossuyt PM et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Syst Rev 10:89. https://doi.org/10.1186/s13643-021-01626-4
Oyu R, Fediaeva VK (2016) The Questionnaire to Assess the Risk of Systematic Bias in Non-Randomized Comparative Studies: the Russian-Language Version of the Newcastle-Ottawa Scale. Med Technol 3:14–19
Andrade C (2020) Understanding the basics of meta-analysis and how to read a forest plot: as simple as it gets. J Clin Psychiatry 81(5):2013698. https://doi.org/10.4088/JCP.20f13698
Borenstein M, Hedges LV, Higgins JPT, Rothstein HR (2009) Introduction to meta-analysis. Wiley, Chichester
Spineli LM, Pandis N (2020) Exploring heterogeneity in meta-analysis: meta-regression analysis. Am J Orthod Dentofacial Orthop 158(4):623–625. https://doi.org/10.1016/j.ajodo.2020.07.002
Cronin P, Kelly AM, Altaee D, Foerster B, Petrou M, Dwamena BA (2018) How to perform a systematic review and meta-analysis of diagnostic imaging studies. Acad Radiol 25(5):573–593. https://doi.org/10.1016/j.acra.2017.12.007
Miyake CY, Del Nido PJ, Alexander ME et al (2011) Cardiac tumors and associated arrhythmias in pediatric patients, with observations on surgical therapy for ventricular tachycardia. J Am Coll Cardiol 58(18):1903–1909. https://doi.org/10.1016/j.jacc.2011.08.005
Bielefeld KJ, Moller JH (2013) Cardiac tumors in infants and children: study of 120 operated patients. Pediatr Cardiol 34:125–128. https://doi.org/10.1007/s00246-012-0399-0
Shi L, Wu L, Fang H, Han B, Yang J, Ma X, Liu F, Zhang Y, Xiao T, Huang M, Huang M (2017) Identification and clinical course of 166 pediatric cardiac tumors. Eur J Pediatr 176(2):253–260. https://doi.org/10.1007/s00431-016-2833-4
Ding P, Qi J, Mo R et al (2020) Clinical treatment of pediatric primary cardiac tumors: a single-institute 12-year experience. Pediatr Hematol Oncol 42(8):488–494. https://doi.org/10.1097/MPH.0000000000001520
Pucci A, Botta G, Sina N et al (2013) Life-threatening tumors of the heart in fetal and postnatal age. J Pediatr 162:964–969
Fan C, Gao Z, Yin NI, Yang J (2015) Surgical treatment of primary cardiac tumors in children: experience of a single institute. Oncol Lett 10(4):2071–2074. https://doi.org/10.3892/ol.2015.3529
Delmo Walter EM, Javier MF, Sander F, Hartmann B, Ekkernkamp A, Hetzer R (2016) Primary cardiac tumors in infants and children: surgical strategy and long-term outcome. Ann Thorac Surg 102(6):2062–2069. https://doi.org/10.1016/j.athoracsur.2016.04.057
Wu KH, Mo XM, Liu YL (2009) Clinical analysis and surgical results of cardiac myxoma in pediatric patients. J Surg Oncol 99(1):48–50. https://doi.org/10.1002/jso.21175
Linnemeier L, Benneyworth BD, Turrentine M, Rodefeld M, Brown J (2015) Pediatric cardiac tumors: a 45-year, single-institution review. World J Pediatr Congenit Heart Surg 6(2):215–219. https://doi.org/10.1177/2150135114563938
Liu X, Hong H, Zhang H, Xu Z, Liu J, Qiu L (2015) Treatment strategies for primary tumors of the heart in children: a 10-year experience. Ann Thorac Surg 100(5):1744–1749. https://doi.org/10.1016/j.athoracsur.2015.06.030
Ying L, Lin R, Gao Z, Qi J, Zhang Z, Gu W (2016) Primary cardiac tumors in children: a center’s experience. J Cardiothorac Surg 11(1):52. https://doi.org/10.1186/s13019-016-0448-5
Padalino MA, Basso C, Milanesi O et al (2005) Surgically treated primary cardiac tumors in early infancy and childhood. J Thorac Cardiovasc Surg 129(6):1358–1363. https://doi.org/10.1016/j.jtcvs.2004.10.020
Padalino MA, Vida VL, Boccuzzo G, Tonello M, Sarris GE, Berggren H, Comas JV, Di Carlo D, Di Donato RM, Ebels T, Hraska V (2012) Surgery for primary cardiac tumors in children early and late results in a Multicenter European Congenital Heart Surgeons Association Study. Circulation 126:2230. https://doi.org/10.1161/CIRCULATIONAHA.111.037226
Padalino MA, Reffo E, Cerutti A et al (2014) Medical and surgical management of primary cardiac tumours in infants and children. Cardiol Young 24:268–274. https://doi.org/10.1017/S104795111300022X
Nathan M, Fabozzo A, Geva T, Walsh E (2014) Successful surgical management of ventricular fibromas in children. Am Assoc Thorac Surg. 148(6):2602–2608
Murat K, Ali K (2018) Rare operations in pediatric heart surgery: Cardiac tumors in childhood. Turk J Thorac Cardiovasc Surg. 26(4):544–549
Nield LE, Mendelson M, Ahmad N, Manlhiot C et al (2014) Clinical review of obstructive primary cardiac tumors in childhood. Congenit Heart Dis 9(3):244–251. https://doi.org/10.1111/chd.12134
Gunther T, Schreiber C, Noebauer C, Eicken A, Lange R (2008) Treatment strategies for pediatric patients with primary cardiac and pericardial tumors: a 30-year review. Pediatr Cardiol 29(6):1071–1076
Bockeria LA, Bockeria OL, Rubtsov PP, Akhobekov AA, Alekhina MA (2014) Experience of treatment of heart rhabdomyomas in combination with various arrhythmias and conduction disorders. Ann Arrhythmol 4(11):204–212. https://doi.org/10.15275/annaritmol.2014.4.3
Konstantinov BA, Nechaenko MA, Kuznetsova LM, Vinnitskiĭ LI, Sheremeteva GF, Khovrin VV, Dombrovskaia AV (2007) Clinical diagnostic and syrgical aspects of heart space-occupying lesions at children and youths. Pirogov Russ J Surg 4:4–8
Bockeria LA, Svobodov AA, Doktorova VP, Serov RA (2017) Surgery management of infants primary cardiac tumors: 10 years practice. Bull A N Bakulev Natl Agric Res Center Russ Acad Med Sci 18(4):391–387. https://doi.org/10.24022/1810-0694-2017-18-4-391-397
Morka A, Kohut J, Radzymińska-Chruściel B, Mroczek T, Gładki M, Weryński P, Rudziński A, Skalski J, Szydłowski L (2020) Echocardiography and newer imaging techniques in diagnosis and long-term follow-up of primary heart tumors in children. Int J Environ Res Public Health 17:5471
Jones JP, Ramcharan T, Chaudhari M, Bhole V, Mcleod K, Sadagopan S, Uzun O, Parry A, Till J, McMahon CJ, Stuart AG (2018) Ventricular fibromas in children, arrhythmia risk and outcomes: a multicentre study. Heart Rhythm. https://doi.org/10.1016/j.hrthm.2018.06.018
Carreon CK, Sanders SP et al (2019) Interdigitating myocardial tongues in pediatric cardiac fibromas plausible substrate for ventricular tachycardia and cardiac arrest. J Am Coll Cardiol 5:563–575. https://doi.org/10.1016/j.jacep.2019.01.022
Funding
This research received no specific grant from any funding agency, commercial, or not-for-profit sectors.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Ethical Approval
This article does not contain any studies with human participants or animals performed by any of the authors.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Svobodov, A.A., Glushko, L.A. & Ergashov, A.Y. Surgical Treatment of Primary Cardiac Tumors in Children Systematic Review and Meta-analysis. Pediatr Cardiol 43, 251–266 (2022). https://doi.org/10.1007/s00246-022-02814-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00246-022-02814-2