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Expression of regional brain amyloid-β deposition with [18F]Flutemetamol in Centiloid scale -a multi-site study

  • Diagnostic Neuroradiology
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A Correction to this article was published on 04 June 2024

This article has been updated

Abstract

Purpose

The Centiloid project helps calibrate the quantitative amyloid-β (Aβ) load into a unified Centiloid (CL) scale that allows data comparison across multi-site. How the smaller regional amyloid converted into CL has not been attempted. We first aimed to express regional Aβ deposition in CL using [18F]Flutemetamol and evaluate regional Aβ deposition in CL with that in standardized uptake value ratio (SUVr). Second, we aimed to determine the presence or absence of focal Aβ deposition by measuring regional CL in equivocal cases showing negative global CL.

Methods

Following the Centiloid project pipeline, Level-1 replication, Level-2 calibration, and quality control were completed to generate corresponding Centiloid conversion equations to convert SUVr into Centiloid at regional levels. In equivocal cases, the regional CL was compared with visual inspection to evaluate regional Aβ positivity.

Results

14 out of 16 regional conversions from [18F]Flutemetamol SUVr to Centiloid successfully passed the quality control, showing good reliability and relative variance, especially precuneus/posterior cingulate and prefrontal regions with good stability for Centiloid scaling. The absence of focal Aβ deposition could be detected by measuring regional CL, showing a high agreement rate with visual inspection. The regional Aβ positivity in the bilateral anterior cingulate cortex was most prevalent in equivocal cases.

Conclusion

The expression of regional brain Aβ deposition in CL with [18F]Flutemetamol has been attempted in this study. Equivocal cases had focal Aβ deposition that can be detected by measuring regional CL.

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Data availability

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Change history

Abbreviations

Aβ:

Amyloid-β

AD:

Alzheimer’s Disease

APOE e4:

Apolipoprotein E allele 4

AIBL:

Australian Imaging Biomarkers and Lifestyle Study

AUC:

Area under ROC

CL:

Centiloid

CTX:

Global cortical target

FOV:

Field of view

FWHM:

Full width half maximum

GAAIN:

Global Alzheimer’s Association Interactive Network

MCI:

Mild cognitive impairment

OHC:

Older healthy control

SPM 8:

Statistical Parametric Mapping 8

SUV:

Standardized uptake value

SUVr:

Standardized uptake value ratio

TE:

Echo time

TR:

Repetition time

VOI:

Volume of interest

WC:

Whole cerebellum

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Acknowledgements

The authors thanked Dr. Henry KF Mak, Clinical Associate Professor, School of Clinical Medicine, the University of Hong Kong for supporting this work by sharing local data. The contribution (including local data collection, data validation, and suggestions for this work) of Prof. Mak is invaluable and should be included as the senior author.

Apology note

We would like to sincerely apologize to our senior author Prof. Henry KF Mak. Due to our negligence, the information of the senior author was not included in the author list during submission. The alteration of the author list is not allowed after online publication. Therefore, we would like to express our apology under this section.

Funding

This study was supported by grants from the special funds for the Science and Technology Programs of Huai'an (HABL202235) and the Science and Technology Development Programs of Nanjing Medical University (NMUB20220204).

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Authors and Affiliations

  1. Department of Medical Imaging Center, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, 1 Huanghe West Road, Huaiyin District, 223300, Huai’an, Jiangsu, China

    Yi-Wen Bao, Li-Li Guo, Gen-Ji Bai & Yun Feng

  2. Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China

    Zuo-Jun Wang

  3. Department of General Surgery, Lianshui County People’s Hospital, 223400, Huai’an, Jiang Su, China

    Guo-Dong Zhao

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Ethical approval

All procedures performed in studies involving human participants were in accordance with the Declaration of Helsinki and approval of the research protocols had official authorization. The protocol of the AIBL study was approved by the institutional human research ethics committees of Austin Health, St Vincent’s Health, Hollywood Private Hospital and Edith Cowan University. The GAAIN cohort used in the current work involves several datasets collected from different studies, which were approved by Washington University's Human Research Protection Office and the Ethical Committees of the participating centers or the Mayo Clinic and Olmsted Medical Center Institutional Review Boards. The study logistics of our local memory clinical complied with the Declaration of Helsinki and ethical approval of the research protocol had been obtained from the Institutional Review Board of the University of Hong Kong.

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Bao, YW., Wang, ZJ., Guo, LL. et al. Expression of regional brain amyloid-β deposition with [18F]Flutemetamol in Centiloid scale -a multi-site study. Neuroradiology (2024). https://doi.org/10.1007/s00234-024-03364-5

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