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Enhancing cyst-like lesions of the white matter in tuberous sclerosis complex: a novel neuroradiological finding

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Abstract

Tuberous sclerosis complex (TSC) is an autosomal dominant condition clinically presenting with heterogenous clinical features. Multiple neuroradiological manifestations have been associated with TSC, such as tubers, radial migration lines, subependymal nodules, subependymal giant cell astrocytomas, and cyst-like lesions of the white matter (CLLWMs). The latter have been described as non-enhancing well-defined cysts whose pathogenesis is still unknown. We describe 2 TSC patients with CLLWM showing contrast enhancement after Gadolinium injection, a previously unreported entity.

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Abbreviations

TSC:

Tuberous sclerosis complex

CLLWM:

Cyst-like lesions of the white matter

CSF:

Cerebro-spinal fluid

MRI:

Magnetic resonance imaging

JPA:

Juvenile pilocytic astrocytoma

DNET:

Dysembryoplastic neuroepithelial tumor

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Funding

No funding was received for this study.

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Authors and Affiliations

  1. Department of Radiology, “Tortorella” Private Hospital, Salerno, Italy

    Alessandra D’Amico

  2. Department of Advanced Biomedical Sciences, University of Naples “Federico II”, Via S. Pansini 5, 80131, Naples, Italy

    Teresa Perillo & Lorenzo Ugga

  3. Pediatric Neuroradiology, Department of Neuroscience, Santobono-Pausilipon Children’s Hospital, Naples, Italy

    Carmela Russo

  4. Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana,” Section of Pediatrics, University of Salerno, Via Salvador Allende, 43 84081, Baronissi, Salerno, Italy

    Daniela Melis

  5. Clinic of Child and Adolescent Neuropsychiatry, Department of Physical and Mental Health, and Preventive Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy

    Claudia Santoro

  6. Department of Women, Children, and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, Naples, Italy

    Claudia Santoro

  7. Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Via Luigi De Crecchio,7, 80138, Naples, Italy

    Giulio Piluso

  8. Department of Pediatric Neurosurgery, Santobono-Pausilipon Children’s Hospital, Naples, Italy

    Giuseppe Cinalli

Authors
  1. Alessandra D’Amico
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  2. Teresa Perillo
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  3. Carmela Russo
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  4. Lorenzo Ugga
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  5. Daniela Melis
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  6. Claudia Santoro
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  7. Giulio Piluso
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  8. Giuseppe Cinalli
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Contributions

• Conceptualization: Alessandra D’Amico

• Methodology: Alessandra D’Amico, Carmela Russo

• Data curation: Alessandra D’Amico, Carmela Russo, Lorenzo Ugga, Daniela Melis, Claudia Santoro, Giulio Piluso

• Writing—original draft preparation: Teresa Perillo

• writing—review and editing: Alessandra D’Amico, Lorenzo Ugga, Teresa Perillo

• supervision: Alessandra D’Amico, Giuseppe Cinalli

All authors read and approved the final manuscript.

Corresponding author

Correspondence to Teresa Perillo.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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D’Amico, A., Perillo, T., Russo, C. et al. Enhancing cyst-like lesions of the white matter in tuberous sclerosis complex: a novel neuroradiological finding. Neuroradiology 63, 971–974 (2021). https://doi.org/10.1007/s00234-021-02647-5

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  • DOI: https://doi.org/10.1007/s00234-021-02647-5

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