Abstract
Unilateral spatial neglect (USN) results from impaired attentional networks and can affect various sensory modalities, such as visual and somatosensory. The rodent medial agranular cortex (AGm), located in the medial part of the forebrain from rostral to caudal direction, is considered a region associated with spatial attention. The AGm selectively receives multisensory input with the rostral AGm receiving somatosensory input and caudal part receiving visual input. Our previous study showed slower recovery from neglect with anterior AGm lesion using the somatosensory neglect assessment. Conversely, the functional differences in spatial attention across the entire AGm locations (anterior, intermediate, and posterior parts) are unknown. Here, we investigated the relationship between the severity of neglect and various locations across the entire AGm in a mouse stroke model using a newly developed program-based analysis method that does not require human intervention. Among various positions of the lesions, the recovery from USN during recovery periods (postoperative day; POD 10–18) tended to be slower in cases with more rostral lesions in the AGm (r = − 0.302; p = 0.028). Moreover, the total number of arm entries and maximum moving speed did not significantly differ between before and after AGm infarction. According to these results, the anterior lesions may slowly recover from USN-like behavior, and there may be a weak association between the AGm infarct site and recovery rate. In addition, all unilateral focal infarctions in the AGm induced USN-like behavior without motor deficits.
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Data sets generated during the current study are available from the corresponding author on reasonable request.
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This work was supported by JSPS KAKENHI (Nos. 18K17725 and 22K19758 to Dr. Ishii; No. 22H04784 to Dr. Osaki; and No. 19H05730 to Dr. Yozu).
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DI, HO, AY, and TY conceived and designed the experiments. DI, HO, and TY collected and analyzed the data. DI, HO, TY, SY, and MM wrote the manuscript. MM and YK supervised all studies. All authors reviewed and revised the manuscript.
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The authors declare no competing interests. All experiments were performed in accordance with the “Guidelines for the Proper Conduct of Animal Experiments” established by the Science Council of Japan in 2006, and were approved by the Animal Care and Use Committee of Ibaraki Prefectural University of Health Sciences (approval number 2022-14).
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Communicated by Melvyn A. Goodale.
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Ishii, D., Osaki, H., Yozu, A. et al. Role of the medial agranular cortex in unilateral spatial neglect. Exp Brain Res (2024). https://doi.org/10.1007/s00221-024-06817-8
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DOI: https://doi.org/10.1007/s00221-024-06817-8