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Enhanced peroxidase-like activity of 2(3), 9(10), 16(17), 23(24)-octamethoxyphthalocyanine modified CoFe LDH for a sensor array for reducing substances with catechol structure

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Abstract

Improving the catalytic activity of artificial nanozymes to realize the real-time detection of small molecules becomes an important task. Herein, a highly active nanozyme, 2(3), 9(10), 16(17), 23(24)-octamethoxyphthalocyanine (Pc(OH)8) modified CoFe LDH microspheres (Pc(OH)8-CoFe LDH) have been prepared by the two-step hydrothermal method. The 3,3′,5,5′-tetramylbenzidine (TMB), a chromogenic substrate, was fast oxidized into blue oxTMB by H2O2 in the presence of Pc(OH)8-CoFe LDH, indicating that Pc(OH)8-CoFe LDH possesses high peroxidase-like activity rather than pure CoFe LDH. The enhancement peroxidase-like activity of the Pc(OH)8-CoFe LDH is ascribed to the synergistic action between Pc(OH)8 and CoFe LDH. Experimental results of radical scavenger and fluorescence probe verify that superoxide radical (•O2−) plays an important role during the catalytic reaction. Interestingly, the absorption intensity of reaction system has been enhanced largely, due to adding of the reducing substances containing catechol structure. Based on this, the three reducing substances (dopamine, procyanidin B2, catechins) containing catechol structure were distinguished from other reducing substances without catechol structure. Thus, a colorimetric array has been constructed using reaction time as the sensing element to realize the sensitive and selective recognition of catechol structures at a certain concentration.

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Funding

This work was supported by the National Natural Science Foundation of China (Grant No. 21971152) and Shandong Key Laboratory of Biochemical Analysis (SKLBA2207).

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Authors and Affiliations

  1. College of Chemical and Biological Engineering, Shandong University of Science and Technology, Qingdao, 266590, People’s Republic of China

    Pingping Hao, Yaru Liu, Guijiang Li & Qingyun Liu

  2. Shandong Hualu-Hengsheng Chemical Co., Ltd, Dezhou, 253024, People’s Republic of China

    Shanmin Dong

  3. Shandong Key Laboratory of Biochemical Analysis, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, 266042, People’s Republic of China

    Gaochao Fan & Guijiang Li

  4. Community Health Service Center (University Hospital), University of Science and Technology Beijing, Beijing, 100083, People’s Republic of China

    Min Xie

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  1. Pingping Hao
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Hao, P., Liu, Y., Dong, S. et al. Enhanced peroxidase-like activity of 2(3), 9(10), 16(17), 23(24)-octamethoxyphthalocyanine modified CoFe LDH for a sensor array for reducing substances with catechol structure. Anal Bioanal Chem 415, 289–301 (2023). https://doi.org/10.1007/s00216-022-04404-w

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