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An edible molecularly imprinted material prepared by a new environmentally friendly deep eutectic solvent for removing oxalic acid from vegetables and human blood

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Abstract

A novel deep eutectic solvent-magnetic molecularly imprinted polymer (DES-MMIP) for the specific removal of oxalic acid (OA) was prepared by an environmentally friendly deep eutectic solvent, consisting of betaine, citric acid, and glycerol, which acted as the functional monomer for polymerization. The structure and morphology of DES-MMIPs were studied by X-ray diffraction, scanning and transmission electron microscopy, thermal gravimetric analysis, Fourier transform infrared spectroscopy, and vibrating sample magnetometer. DES-MMIPs had a core–shell structure, with magnetic iron oxide as the core, and showed good thermal stability and high adsorption capacity (18.73 mg/g) for OA. The adsorption process of OA by DES-MMIPs followed the pseudo-second-order kinetic model and Langmuir isotherm model. DES-MMIPs had significant selectivity for OA and their imprinting factor was 3.26. When applied to real samples, high performance liquid chromatography analysis showed that DES-MMIPs could remove OA from both spinach and blood serum. These findings provide potential methods for removal of OA from vegetables and for specific removal of OA in renal dialysis.

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Funding

This work was financially supported by National Natural Science Foundation of China (No. 81973451); Fundamental and Frontier Research Fund of Chongqing (No. cstc2018jcyjAX0661; No. cstc2019jsyj-yzysbAX0020); the Science and Technology Research Program of Chongqing Municipal Education Commission (No. KJZD-K201800103); Fundamental Research Funds for the Central Universities (No. 2019CDYGYB027) and Venture & Innovation Support Program for Chongqing Overseas Returnees, and Tang Foundations.

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Author notes

  1. Yan-Jun Li and Jia-Yuan He contributed equally to this work.

Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, 400044, China

    Yan-Jun Li, Jia-Yuan He, Qing-Yao Li, Li-Li Yang, Rong-Rong Ma & Qi-Hui Zhang

  2. Tang Center for Herbal Medicine Research and Department of Anesthesia & Critical Care, University of Chicago, Chicago, IL, 60637, USA

    Chong-Zhi Wang, Qi-Hui Zhang & Chun-Su Yuan

  3. Basic Medical College, Chongqing Medical University, Chongqing, 400016, China

    Lian-Di Zhou

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  1. Yan-Jun Li
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Contributions

Investigation, data curation, formal analysis, and writing—original draft: Yan-Jun Li and Jia-Yuan He; methodology: Qing-Yao Li; writing—review and editing: Li–Li Yang and Rong-Rong Ma; project administration: Chong-Zhi Wang; supervision and visualization: Lian-Di Zhou; conceptualization, validation, resources, project administration, and funding acquisition: Qi-Hui Zhang and Chun-Su Yuan. All authors have approved the final version of the manuscript.

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Correspondence to Lian-Di Zhou or Qi-Hui Zhang.

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Li, YJ., He, JY., Li, QY. et al. An edible molecularly imprinted material prepared by a new environmentally friendly deep eutectic solvent for removing oxalic acid from vegetables and human blood. Anal Bioanal Chem 414, 2481–2491 (2022). https://doi.org/10.1007/s00216-022-03889-9

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