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A comprehensive review on Schisandrin and its pharmacological features

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Abstract

Schisandrin stands as one of the primary active compounds within the widely used traditional medicinal plant Schisandra chinensis (Turcz.) Baill. This compound exhibits sedative, hypnotic, anti-aging, antioxidant, and immunomodulatory properties, showcasing its effectiveness across various liver diseases while maintaining a favorable safety profile. However, the bioavailability of schisandrin is largely affected by hepatic and intestinal first-pass metabolism, which limits the clinical efficacy of schisandrin. In this paper, we review the various pharmacological effects and related mechanisms of schisandrin, in order to provide reference for subsequent drug research and promote its medicinal value.

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Acknowledgements

This work was supported by “Climbing Peak” Training Program for the Innovative Technology team of Yijishan Hospital of Wannan Medical College (Grant number KPF2019016). Figures 2–3. Created with http://BioRender.com.

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Authors and Affiliations

  1. Anhui Provincial Center for Drug Clinical Evaluation, Yijishan Hospital of Wannan Medical College, No. 2, Zheshan West Road, Jinghu District, Wuhu, 241000, China

    Xiaohu Wang, Xingwen Wang, Chaozhuang Shen, Kuo Geng & Haitang Xie

  2. Wannan Medical College, No.22, Wenchang West Road, Yijiang District, Wuhu, 241000, China

    Xiaohu Wang & Hui Yao

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  1. Xiaohu Wang
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Xiaohu Wang and Xingwen Wang prepared the original draft. Hui Yao, Chaozhuang Shen and Kuo Geng contributed in reviewing and editing. Haitang Xie conceived and designed the project. The authors confirm that no paper mill and artificial intelligence was used.

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Correspondence to Haitang Xie.

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Wang, X., Wang, X., Yao, H. et al. A comprehensive review on Schisandrin and its pharmacological features. Naunyn-Schmiedeberg's Arch Pharmacol 397, 783–794 (2024). https://doi.org/10.1007/s00210-023-02687-z

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