Abstract
The goal of the current study was to investigate the antioxidant, anti-ulcer, and analgesic properties of a metal-curcumin complex (MCC) utilizing different mouse and rat models. The antioxidant component of the analysis was completed in vitro, whereas the other activities were completed in vivo. The 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical cation scavenging test, the ferric-reducing antioxidant power (FRAP) assay, and the 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) free radical scavenging assay were used to measure the antioxidant activity. MCC demonstrated potent radical scavenging abilities. In all three experiments, Trolox served as the reference substance. When curcumin’s radical scavenging abilities were compared, it became clear that MCC was a superior radical scavenger. Using the ethanol-induced technique on Sprague–Dawley rats, the anti-ulcerogenic effect was assessed. It shows that at an oral dosage of 100 mg/kg body weight, MCC might provide gastroprotection (b.w.). Additionally, we have examined MCC’s potential as an analgesic. Swiss albino mice were used to measure the analgesic activity of MCC using the hot plate technique. At an oral dosage of 50 mg/kg b.w., MCC displayed analgesic efficacy. As a result, MCC could be useful in the management of inflammatory diseases.
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AJ and SL designed research, and AJ and SL performed in vitro antioxidant assays. BL and DK conducted the analgesic activity. PP and SP conducted the anti-ulcer activity. AJ analyzed the data. AJ wrote the manuscript. All authors read and approved the manuscript. AJ and SL gave final approval to the manuscript submission. The authors declare that all data were generated in-house and that no paper mill was used.
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Joshi, A., Lehene, S., Lasnapure, B. et al. Investigation of antioxidant, anti-ulcer, and analgesic potential of a metal-curcumin complex. Naunyn-Schmiedeberg's Arch Pharmacol 396, 1043–1052 (2023). https://doi.org/10.1007/s00210-022-02381-6
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DOI: https://doi.org/10.1007/s00210-022-02381-6