Abstract
This study aimed to evaluate and pinpoint the status, hot areas, and frontiers of immune activation during HIV infection utilizing CiteSpace. From 1990 to 2022, we searched for studies on immune activation during HIV infection in the Web of Science Core Collection. CiteSpace was used to visually analyze the publications to identify the research status and pertinent research hotspots and frontiers in terms of the countries, institutions, authors, references, journals, and keywords. The Web of Science Core Collection yielded 5321 articles on immune activation during HIV infection. With 2854 and 364 articles, the United States and the University of California, San Francisco were the leading nation and institution in this domain. Steven G. Deeks has published 95 papers and is the most published author. The top cited articles on microbial translocation as a significant factor during HIV infection were published by Brenchley et al. Research on molecular/biology/genetics is often referenced in publications in the journals of molecular/biology/immunology. Inflammation, risk, mortality, cardiovascular disease, persistence, and biomarkers will be high-frequency words that are hot topics of research. According to the results, there was a strong collaboration between countries and organizations but little collaboration among authors. Molecular biology, immunology, and medicine are the main study subjects. The current hot topics in research are inflammation, risk, mortality, cardiovascular disease, persistence, and biomarkers. Future studies should concentrate on reducing the pathological changes caused by inflammation and altering the mechanisms of immune activation to reduce the size of the viral reservoir.
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Acknowledgements
We wish to thank Yu Lai for his assistance in study conception and design.
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This work was supported by the Xinglin Scholar Research Promotion Project of Chengdu University of TCM (Grant Number XSGG2020001). The Xinglin Scholar Research Promotion Project of Chengdu University of TCM had no role in designing the study, collecting the data, analyzing the data, interpreting the data, writing the report, or in the decision to submit the paper for publication.
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YL contributed to the study's conception and design. Material preparation, data collection, and analysis were performed by KG. The first draft of the manuscript was written by KG, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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Gong, K., Lai, Y. Development trends of immune activation during HIV infection in recent three decades: a bibliometric analysis based on CiteSpace. Arch Microbiol 205, 283 (2023). https://doi.org/10.1007/s00203-023-03624-7
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DOI: https://doi.org/10.1007/s00203-023-03624-7