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Trabecular bone score in adults with type 1 diabetes: a meta-analysis

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Abstract

Summary

Type 1 diabetes mellitus (T1DM) is associated with a disproportionately high fracture rate despite a minimal decrease in bone mineral density. Though trabecular bone score (TBS), an indirect measure of bone architecture, is lower in adults with T1DM, the modest difference is unlikely to account for the large excess risk and calls for further exploration.

Introduction

Fracture rates in type 1 diabetes mellitus (T1DM) are disproportionately high compared to the modestly low bone mineral density (BMD). Distortion of bone microarchitecture compromises bone quality in T1DM and is indirectly measured by trabecular bone score (TBS). TBS could potentially be used as a screening tool for skeletal assessment; however, there are inconsistencies in the studies evaluating TBS in T1DM. We performed this meta-analysis to address this knowledge gap.

Methods

An electronic literature search was conducted using PubMed, Scopus, and Web of Science resources (all-year time span) to identify studies relating to TBS in T1DM. Cross-sectional and retrospective studies in adults with T1DM were included. TBS and BMD data were extracted for pooled analysis. Fracture risk could not be analyzed as there were insufficient studies reporting it.

Result

Data from six studies were included (T1DM: n = 378 and controls: n = 286). Pooled analysis showed a significantly lower TBS [standardized mean difference (SMD) =  − 0.37, 95% CI − 0.52 to − 0.21; p < 0.00001] in T1DM compared to controls. There was no difference in the lumbar spine BMD (6 studies, SMD − 0.06, 95% CI − 0.22 to 0.09; p = 0.43) and total hip BMD (6 studies, SMD − 0.17, 95% CI − 0.35 to 0.01; p = 0.06) in the case and control groups.

Conclusions

Adults with T1DM have a lower TBS but similar total hip and lumbar spine BMD compared to controls. The risk attributable to the significant but limited difference in TBS falls short of explaining the large excess propensity to fragility fracture in adults with T1DM. Further studies on clarification of the mechanism and whether TBS is suited to screen for fracture risk in adults with T1DM are necessary.

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Authors and Affiliations

  1. Department of Endocrinology, Indraprastha Apollo Hospitals, Sarita Vihar, Delhi, India

    Saptarshi Bhattacharya

  2. Department of Endocrinology, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, Karnataka, India

    Lakshmi Nagendra

  3. Osteoporosis and Bone Metabolism Unit, Department of Endocrinology, Singapore General Hospital, Singapore, Singapore

    Manju Chandran

  4. DUKE NUS Medical School, Singapore, Singapore

    Manju Chandran

  5. Department of Endocrinology, Diabetes, and Metabolism, Christian Medical College and Hospital, Vellore, Tamil Nadu, India

    Nitin Kapoor

  6. B Non-Communicable Disease Unit, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia

    Nitin Kapoor

  7. Central Research Laboratory, K.S Hegde Medical Academy (KSHEMA), NITTE (Deemed to Be University), Mangalore, Karnataka, India

    Prakash Patil

  8. Department of Endocrinology, Centre for Endocrinology, Arthritis, and Rheumatism (CEDAR), Superspeciality Healthcare, Dwarka, New Delhi, India

    Deep Dutta

  9. Department of Endocrinology, Bharti Hospital, Karnal, Haryana, India

    Sanjay Kalra

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  1. Saptarshi Bhattacharya
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Bhattacharya, S., Nagendra, L., Chandran, M. et al. Trabecular bone score in adults with type 1 diabetes: a meta-analysis. Osteoporos Int 35, 105–115 (2024). https://doi.org/10.1007/s00198-023-06935-z

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