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The relationship between vaginal microenvironment and pelvic dysfunctional diseases in Chinese women: a systematic review and meta-analysis

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Abstract

Objective

The aim of this review is to synthesize existing evidence on the combined effects of the vaginal microenvironment on pelvic dysfunctional diseases.

Methods

This systematic review was conducted in accordance with the PRISMA guidelines. The PubMed, Embase, Cochrane Library, Web of Science, Wanfang, and China Knowledge Network (CNKI) databases were systematically searched up to January 2023 using the following MeSH terms: "pelvic organ prolapse", "stress urinary incontinence" and "vaginal microenvironment", "microenvironment", "vaginal cleanliness", "vaginitis", "lactobacillus" and other related keywords. Study methods were limited to case–control studies or cross-sectional studies. Quality assessment was performed using the Newcastle–Ottawa scale, and meta-analysis of the included literature was performed using Review Manager 5.3.

Results

A total of eight articles were included in this systematic review (SR) and meta-analysis (MA), which involved a total of 7298 study participants. The pooled results of this meta-analysis showed that the vaginal microenvironment (number of vaginal lactobacilli, leukorrhea cleanliness, and presence of vaginitis) were all statistically significantly associated with pelvic dysfunctional diseases in Chinese women.

Conclusion

This review indicates that the vaginal microenvironment has an impact on the development of PFD in Chinese women.

Trial registration

The protocol of this systematic review (SR) and meta-analysis (MA) has been registered in PROSPERO databases with the Registration number of CRD42023407251

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Authors and Affiliations

  1. The First Clinical College of Medicine, Chongqing Medical University / The First Hospital of Chongqing Medical University, 1 Youyi Road, Yuanjiagang, Yuzhong District, Chongqing, 400010, China

    Ye Yu, MingRong Ma & Qin Zhou

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  1. Ye Yu
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  2. MingRong Ma
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  3. Qin Zhou
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Contributions

Ye Yu: project development, data collection, manuscript writing

Zhou Qin: project development

Minrong Ma: data collection

Corresponding author

Correspondence to Qin Zhou.

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All analyses were based on previous published studies, thus no ethical approval and patient consent are required.

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Yu, Y., Ma, M. & Zhou, Q. The relationship between vaginal microenvironment and pelvic dysfunctional diseases in Chinese women: a systematic review and meta-analysis. Int Urogynecol J 34, 2849–2858 (2023). https://doi.org/10.1007/s00192-023-05635-w

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  • DOI: https://doi.org/10.1007/s00192-023-05635-w

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