What Turns Knowledge into Innovative Products? The Role of Entrepreneurship and Knowledge Spillovers

The knowledge spillover theory of entrepreneurship seeks to explain the fundamentals and consequences of entrepreneurship with respect to economic performance. This paper uses the knowledge spillover theory to explain different innovation outcomes. We hypothesize that a high rate of entrepreneurship facilitates the process of turning knowledge into new-to-the-market innovation but has no effect on the relationship between knowledge and new-to-the-firm innovation. Our results using European country-level and pooled OLS, fixed- and random-effects regressions show that a high rate of entrepreneurship increases the chances that knowledge will become new-to-the-market innovation. The findings highlight the importance of Schumpeterian entrepreneurship in the process of the commercialization of knowledge. We discuss the implications for entrepreneurship and innovation policy.


Introduction
Endogenous growth theory assumes that an economy automatically benefits from its investments in new knowledge (Lucas, 1988;Romer, 1990) because knowledge is a public good that can be used by an entire economy, leading to innovation and economic growth (Cantner et al., 2008). In the empirical world of the R&D capital approach (Mansfield, 1965;Griliches, 1998Griliches, , 2000, the development of total factor productivity (TFP) is explained using an R&D stock variable. 1 Although a great deal of evidence shows that knowledge (R&D stock) leads to growth (TFP growth), some countries seem to benefit more from investments in new knowledge than others. The US, for example, is thought to commercialize new knowledge better than Europe, giving rise to what is referred to as the Swedish paradox (Ejermo and Kander, 2006) or the European paradox (Audretsch, 2007). Investment in new knowledge is only one necessary condition; new knowledge must be exploited and put to commercial use so that it can translate into stronger competitiveness and subsequent economic growth (Braunerhjelm and Svensson, 2010;Carlsson et al., 2010). This barrier between knowledge and its commercialization is referred to as the knowledge filter . 2 The contribution of Acs et al. (2009) extends the microeconomic foundations of endogenous growth models (Lucas, 1988;Romer, 1990) through the knowledge spillover theory of entrepreneurship, which holds that knowledge creation can lead to knowledge spillovers, creating technological opportunities. Entrepreneurs then exploit these opportunities, leading to economic growth and development. New product innovations may come from both incumbent firms and start-ups. Incumbent firms mainly produce incremental innovations from the flow of knowledge, whereas start-ups tend to exploit knowledge spillovers to produce radical innovations.  use the knowledge spillover theory of entrepreneurship to explain the European or Swedish paradox (Ejermo and Kander, 2006;Audretsch, 2007). They develop a theoretical model in which the transformation of knowledge into economic growth depends on how knowledge diffuses through both incumbent and entrepreneurial activity. The entrepreneur is the "missing link in converting knowledge into economically relevant knowledge" (Braunerhjelm et al., 2010, p. 105). Based on OECD data from 1981 to 2002, they show that entrepreneurship Granger-causes economic growth and that this effect increased in the 1990s, as the knowledge economy began to grow.
Our paper links the knowledge spillover theory of entrepreneurship ) to empirical innovation research using different types of innovation as outcome variables. Whereas the empirical model of  tests the effects of entrepreneurship on economic growth when the link to innovation is indirect, we seek to explain the effect of entrepreneurship on the transformation of knowledge into innovation. A research gap exists in the link between the knowledge spillover theory of entrepreneurship and empirical research about innovation and the commercialization of knowledge Braunerhjelm and Svensson, 2010). In our paper, we will discriminate between innovations that are new to the market and those that are new to the firm. Based upon the knowledge spillover theory, we hypothesize that a high rate of entrepreneurship facilitates the process of turning knowledge into new-to-the-market innovation but has no important effect on the relationship between knowledge and new-to-the-firm innovation.
Our focus, and, therefore, our unit of observation, is at the country level rather than at the individual-firm level. We use a panel dataset that covers the innovation activity of 21 European countries in four waves, corresponding to the period from 1996 to 2006. The results clearly show that entrepreneurship, measured as the business ownership rate, is an important driver for turning 1 The R&D capital approach also takes into account international effects, such as those of foreign R&D, import shares, openness and catch-up mechanisms. See Erken et al. (2009). 2 This concept was first presented in two CEPR discussion papers 2005). knowledge into new-to-the-market innovation but has no impact on new-to-the-firm innovation. This finding is precisely what the knowledge spillover theory of entrepreneurship and prior entrepreneurship research predicts. Entrepreneurs as individuals are considered risk takers (Kihlstrom and Laffont, 1979) who are tolerant of ambiguity (Schere, 1982). Thus, they play an important role when risk and uncertainty are involved, such as new-to-the-market innovations, but less so for new-to-the-firm innovations, for which product uncertainty and risk are much lower. Our paper contributes to our understanding of the knowledge spillover theory, particularly why and under what conditions entrepreneurship leads to innovation and economic growth. This paper also enhances understanding of the types of innovation that are most closely related to entrepreneurship.
Following this introduction, Section 2 introduces the literature on economic growth, knowledge spillovers and types of innovation. Section 3 develops our hypotheses using the knowledge spillover theory of entrepreneurship and links this theory to different innovation outcomes. Section 4 summarizes our data and the empirical model. Section 5 reports our regression results, which are discussed in Section 6.

Entrepreneurship and economic growth
A small part of the literature on the economics of entrepreneurship focuses on the role of entrepreneurship as it impacts economic growth. In this literature, entrepreneurship is often presented as an additional production factor, called entrepreneurship capital (Audretsch, 2007). In this sense, however, it does not contribute to our understanding of the exact mechanism of the transformation of knowledge into economic growth. The main question is why entrepreneurship leads to growth. Literature surveys of the influence of entrepreneurship on economic growth (Van Praag and Versloot, 2007;Braunerhjelm, 2008;Parker, 2009;Carree and Thurik, 2010) are relatively vague, except to say that entrepreneurship is expected to lead to diversity, innovation, competition, employment, and learning, at which point economic growth occurs. Among the studies of entrepreneurship and economic growth, Baumol (2002) is the clearest in stating that innovation is the essence of economic growth. The knowledge spillover theory of entrepreneurship  is an important step in understanding the microeconomic foundations of how entrepreneurship leads to economic growth. In the three succeeding subsections, we briefly summarize the literature on knowledge spillovers and the knowledge spillover theory of entrepreneurship, and then we turn to the main focus of this study: the different types of innovation and their relation to knowledge.

Knowledge spillovers and geographical boundaries
The production of knowledge can lead to spillovers when individuals or organizations other than the creators of knowledge benefit from the knowledge that the creator has produced. Thus, by investing in knowledge, a firm not only increases its own level of knowledge but also contributes to the aggregate stock of knowledge (Romer, 1986;Lucas, 1993;Griliches, 1998). For example, when securing a patent, a firm produces new knowledge, and the information included in the patent becomes accessible to the general public and to competitors. A competitor may use the information from the patent for its own research and invest in related knowledge, and this related knowledge may lead to new patents or innovative products. In other words, knowledge may spill over from one firm to another. There is extensive research on knowledge spillovers in multiple contexts, such as technology transfer (e.g., Anselin et al., 1997;Carlsson and Fridh, 2002), innovation networks (e.g., Breschi and Lissoni, 2001), technology clusters (e.g., Werker and Athreye, 2004), and the evolution of industries (e.g., Malerba, 2006). This research has shown that geographical proximity matters if knowledge spillovers are to occur. Although knowledge may spill over to firms or individuals far from the creator of knowledge, the literature has shown that spillovers are more likely to occur on a local level (Jaffe et al., 1993;Anselin et al., 1997;Varga, 2000;Keller, 2002;Bottazzi and Peri, 2003). Anselin et al. (1997) show that university research and regional innovative activities are positively related, and there is evidence that university research impacts business R&D both directly and indirectly. Using a dataset that covers most of the world's innovative activity between 1970, Keller (2002 shows that the benefits of knowledge spillovers decline with distance. However, there is evidence of an autonomous time trend towards more global knowledge diffusion.

The knowledge spillover theory of entrepreneurship
Entrepreneurship is identified by its role in the recognition, discovery, and creation of opportunities (Shane and Venkataraman, 2000). Little is known, however, about the source of these opportunities. The knowledge spillover theory of entrepreneurship ; for a collection of recent papers, see Acs, 2010) has helped to close this gap in understanding, and knowledge spillovers are now regarded as a possible source of entrepreneurial opportunities, called endogenous entrepreneurship. 3 Due to the noncompetitive nature of knowledge as an asset, it may spill over so that the producers of knowledge are not able to appropriate the entire value of their knowledge for themselves. These spillovers may then serve as a source of opportunities for other firms and for individuals who want to start their own businesses . The knowledge spillover theory of entrepreneurship holds that entrepreneurial activity is greater when there is greater investment in knowledge. This argument is supported by Audretsch and Lehmann (2005), among others, who show that regions with greater investments in new knowledge also have higher start-up rates. Another facet of the theory holds that opportunities for entrepreneurship are superior when the ability to access knowledge spillovers from geographically proximate sources is greater, based on the assumption that knowledge spillovers increase economic performance (Lucas, 1988;Romer, 1990;Glaeser et al., 1992;Acs and Armington, 2004) and that this relationship is moderated by geographical proximity (Jaffe et al., 1993;Anselin et al., 1997;Varga, 2000;Keller, 2002;Bottazzi and Peri, 2003). This is especially likely when the entrepreneur is located in close proximity to universities, large high-tech firms or other research-intensive institutions that produce knowledge (Anselin et al., 1997;Carlsson and Fridh, 2002).
In short, the knowledge spillover theory shows how entrepreneurship can contribute to growth by helping knowledge to spill over or to permeate the filter that impedes knowledge spillover. The knowledge spillover theory attributes importance not only to the role of persons but also to regional agglomerations of knowledge activities (entrepreneurship capital) that become the breeding ground for growth.

Knowledge and types of innovation
The literature discusses the following types of innovation and innovation indicators: (1) R&D efforts, (2) patent measures, and (3) product-related indicators (Hauser and Zettelmeyer, 1997;Kleinknecht et al., 2002). R&D efforts comprise R&D as a percentage of sales or assets and measure a firm's input in the innovation process. R&D efforts also serve to measure a firm's absorptive capacity (Cohen and Levinthal, 1989) and knowledge potential. Patent measures, which comprise patent counts and patent issuances, may be interpreted as output-based measures of technological knowledge (Park and Park, 2006). Product-related innovation indicators refer to measures of new product introduction. New product introductions can be differentiated into newto-the-firm and new-to-the-market product introductions. The former category is sometimes interpreted as imitative behavior, and the latter category is interpreted as 'true' innovation (Kleinknecht et al., 2002). Due to their high degree of novelty, new-to-the-market innovations are characterized by high levels of technological and market uncertainty (Scherer et al., 2000), whereas this may not be true of new-to-the-firm innovation. The risk of customer acceptance can be reduced with a strategy of imitation because the product is already known to the market and to its customers (Bolton, 1993). In conjunction with differences in the degree of uncertainty, newto-the-market innovation should show a stronger association with patents than new-to-the-firm innovation because novelty is a central requirement for the patentability of an invention. Our paper aggregates firm-level innovation data to the country level and then distinguishes between a country's level of new-to-the-firm and new-to-the-market innovations as outcome variables.

Entrepreneurship as a factor that turns knowledge into innovation
The purpose of this paper is to apply the knowledge spillover theory of entrepreneurship  to analyze the effect of entrepreneurship in turning knowledge into different innovation outcomes. As summarized in the preceding section, existing literature using the knowledge spillover theory of entrepreneurship examines the sources of entrepreneurship and their effects on economic growth. The link between entrepreneurship and innovation is indirect. For example, the literature suggests that entrepreneurship increases economic output by facilitating the commercialization of knowledge, but this link has not been analyzed in detail, and no distinction has been made between different types of innovation (Hauser and Zettelmeyer, 1997;Kleinknecht et al., 2002). This paper attempts to take the first steps in these directions by arguing that entrepreneurship is more likely to influence the process that leads knowledge to be converted into new-to-the-market innovations as opposed to new-tothe-firm innovations.
Innovation relates to two interrelated processes, the production of knowledge 4 and the exploitation of knowledge. We focus on the exploitation phase, particularly on the mechanism that turns knowledge into innovative products. The commercialization of knowledge, especially new knowledge, includes efforts such as financing product development or market research. The outcome of this process is often uncertain and requires a risk-taking attitude among the managers of the process, making the entrepreneurial attitude important at this stage. Entrepreneurs are considered different from other individuals because, for example, they are believed to have an above-average level of willingness to take risks (Block, Sandner, and Spiegel, 2010;Kihlstrom and Laffont, 1979;Brockhaus, 1980), a tolerance for ambiguity (Timmons, 1976;Schere, 1982), a need for achievement (McClelland, 1961), and a preference for autonomy (Benz and Frey, 2008;Block and Koellinger, 2009). In particular, risk-taking and a tolerance for ambiguity are crucial for managing the process of commercializing new knowledge. A high rate of entrepreneurship and exposure to an entrepreneurial climate thus facilitates the process of turning knowledge into innovative products (Beugelsdijk, 2007). Thus, we propose the following hypothesis:

Entrepreneurship moderates the relationship between knowledge and new-to-the-market innovation.
We hypothesize that entrepreneurship has little or no effect on turning knowledge into newto-the-firm innovation because this type of innovation requires less risk taking and uncertainty. New-to-the-firm innovation is 'imitative' innovation and is associated with little market and/or technology uncertainty. It requires different skills and capabilities than new-to-the-market 4 The production of knowledge is emphasized by Baumol (2002), who represents the Schumpeterian (1934) view that an environment in which most of the breakthrough innovation occurs in small firms and most of the improvement on those innovations and wide-scale dissemination occurs in large firms is an efficient one. See Ortega-Argilés, Vivarelli and Voigt (2009) for a survey of the various roles of small firms in the process of technological change.
innovation, and places more importance on a firm's learning and imitation capabilities (Cohen and Levinthal, 1989;Schewe, 1996) than on entrepreneurship. Hence, we propose the following hypothesis:

Data and empirical model 4.1 Data sources
Our study combines data from the Community Innovation Survey (CIS) 5 , the COMPENDIA database 6 , and the OECD Economic Outlook Database. 7 The CIS is commissioned by the European Commission and records the innovation activity of firms in the EU member states, in EU candidate countries, and in Iceland and Norway. The first CIS was conducted in 1993 using a pilot version (CIS1). Since then, four additional surveys have been conducted: CIS2 (1996), CIS3 (1998, CIS4 (2002), and CIS2006 (2004-2006. The survey unit of the CIS is the enterprise, and the target population is the total population of enterprises in a particular country. Because sampling rates may differ across countries, the CIS uses a stratified sampling procedure and weighting procedures to ensure that the samples are representative of the total population of enterprises in each country. The results of the firm-level CIS are aggregated and transmitted to Eurostat on a compulsory basis. CIS data are accepted in the research community and have been widely used in innovation research (Arundel, 2001;Mohen, 2002, 2005;Hoelzl, 2009).

COMPENDIA (COMParative ENtrepreneurship Data for International Analysis) is developed and maintained by EIM Business and Policy Research (a Panteia company) in the
Netherlands. The database summarizes and harmonizes information about the number of business owners and the size of the labor force from the OECD databases, the ILO Yearbook of Labour Statistics and the European Observatory for SMEs. The quotient of these two variables is called the business ownership rate (Van Stel, 2005). Business ownership includes all unincorporated self-employed persons and owner-managers of incorporated businesses (OMIBs) (Van Stel, 2005). Although it has been argued that business ownership is not synonymous with entrepreneurship, Carree et al. (2002) acknowledge that the level of business ownership is a fair reflection of the level of entrepreneurship in a particular country. The main advantage of this harmonized dataset is that it makes entrepreneurship activity comparable across countries and over time. The latest version of the COMPENDIA consists of 23 OECD countries for the period of 1972-2007.
The OECD Economic Outlook Database indicates historical trends and future projections for a wide range of macro indicators that describe the demographic, social, economic and environmental developments of a country, including the gross domestic product, rate of unemployment and deflators and prices. The dataset encompasses longitudinal information on macro indicators from the 30 OECD member countries and 6 selected non-OECD countries. We rely on this database to build our country-specific control variables. 5 Extended information is available at http://epp.eurostat.ec.europa.eu/portal/page/portal/science_technology_innovation/data/database (accessed September 7, 2009).
Our final assembled dataset includes aggregated information on innovation activity from manufacturing firms (NACE 15-37), 8 business ownership rates, and macro indicators for 21 European countries 9 in four waves during the period from 1996 to 2006. We restrict our sample to the manufacturing sector to ensure that our results are not driven by differences in industry structure between countries. Because not all countries are included in each wave, our final dataset takes the form of an unbalanced panel dataset.

Dependent variables
The measurement of innovation includes various dimensions and varies according to firms and their life-cycle phases. Innovation and its performance can be measured in many ways: by the turnover of new products, increases in productivity or decreases in production cost as a result of introducing new processes, or customer satisfaction with new products or services (for overviews, see Hauser andZettelmayer, 1997, andKleinknecht et al., 2002). The CIS measures innovation performance in two ways: (1) shares of turnover attributable to new or significantly improved products that are new to the firm (variable new-to-the-firm innovation) and (2) shares of turnover attributable to new or significantly improved products that are new to the market (variable newto-the-market innovation). With respect to new-to-the-firm innovation, the CIS asks respondents to state the share of "goods and service innovations introduced during the last three years that were only new to your firm (your enterprise introduced a new or significantly improved good or service that was already available from your competitors in your market)". With respect to newto-the-market innovation, the CIS asks the respondents to report the share of "goods and service innovations introduced during the last three years that were new to your market (your enterprise introduced a new or significantly improved good or service onto your market before your competitors) […]".
As noted in our theory section, we argue that entrepreneurship and an entrepreneurial attitude are particularly important with regard to new-to-the-market innovation and are less important for new-to-the-firm innovation.

Independent variables
Rate of knowledge-intensive firms. As discussed above, the production of new knowledge is a crucial factor that leads to innovation. We measure a country's level of knowledge as the share of firms that applied for at least one patent in the survey year. We consider this measure a good proxy for knowledge in the context of this study because patents are property rights granted by a patent authority, such as the European Patent Office (EPO). For a patent to be granted, the invention must be non-trivial and must have potential commercial value. Patents have been used in a number of studies as a proxy for knowledge and knowledge spillover (Jaffe et al., 1993(Jaffe et al., , 2000Acs et al. 2002, Furman et al., 2002. We use data obtained from the CIS. As a robustness check, as proxies for knowledge production, we use alternative measures, such as a country's gross expenditure on R&D or its level of business R&D. We believe, however, that patent-based measures are more appropriate than R&D-based measures for our particular research question because our paper examines the role of entrepreneurship in turning 'commercializable' knowledge into innovation. Patents constitute an intermediate output of knowledge production (Kleinknecht et al., 2002) and are proxies for knowledge that can be commercialized. Not surprisingly, we find that our patent-based knowledge measure correlates strongly with a country's gross expenditure on R&D (r=0.68, p<0.01) and/or its level of business R&D (r=0.69, p<0.01).
Entrepreneurship rate: Because of the heterogeneous context of entrepreneurship, there is no unique variable that measures entrepreneurship or entrepreneurial climate. Commonly used measures are self-employment rates, business ownership rates, and numbers of new firm start-ups. We use the business ownership rate to measure entrepreneurship. Our results also hold when we use the rate of self-employment as a proxy for entrepreneurship. The business ownership rate is calculated as the share of business owners in the total labor force. Business owners are defined as individuals whose main occupation is self-employment, including owner-managers of incorporated businesses. The data are obtained from COMPENDIA. As an alternative entrepreneurship measure, we could have used data from the Global Entrepreneurship Monitor (GEM) (Acs and Varga, 2005;Reynolds et al., 2005). However, there is little overlap between the CIS data, which we used to construct our two dependent variables, new-to-the-firm innovation and new-to-the-market innovation, and the GEM data. In particular, we would not be able to run panel data regressions and control for unobserved heterogeneity.

Control variables:
To control for macro-economic influences, two macro-economic variables are included in the regression models, GDP and GDP per capita. These variables are taken from the OECD Economic Outlook Database. To achieve comparability over time, the values of GDP and GDP per capita are adjusted to 1995 prices. Both variables are represented as logged values and refer to a country's size or level of wealth. As robustness checks, we also include the variables share of small firms and share of venture capital investments in GDP as additional controls.

Empirical model
The following two pooled OLS equations are used for the empirical analysis: where I is either new-to-the-market innovation (the share of turnover attributable to new or significantly improved products that are new to the market) or new-to-the-firm innovation (the share of turnover attributable to new or significantly improved products that are new to the firm); K denotes the rate of knowledge-intensive firms measured by the share of firms that applied for at least one patent in the last three years; E denotes the business ownership rate as a proxy for the entrepreneurship rate; Controls denotes the control variables, which are the natural logarithm of GDP and the natural logarithm of GDP per capita; Years corresponds to year dummies for the years 1998, 2000, 2004, and 2006; and i and t are country and year indices, respectively. Table 1 describes the construction of the variables in more detail. To conduct a robustness check, we estimated random-and fixed-effects regressions (Wooldridge, 2002) using the same variables.

Descriptive statistics
Descriptive statistics for the variables are presented in Table 2. The mean percentage of turnover for new-to-the-market innovations is 8%, with a variation of 1% to 24%. The mean percentage of turnover for new-to-the-firm innovations is 13%, with a variation of 4% to 41%. The mean rate of entrepreneurship is 11%, with a variation of 5% to 21%, and the mean proportion of firms that applied for a patent is 10%, with a range of 2% to 27%. Table 3 shows a correlation table. The variables new-to-the-market innovation and new-to-the-firm innovation are not correlated (r=0.05, p>0.1), indicating that they relate to different characteristics of new products (and countries). Except for the correlations between knowledge and the natural logarithm of GDP per capita as well as knowledge and new-to-the-firm innovation, all correlations are below 0.5. With innovation and imitation performance as the dependent variables, the variance inflation factors (VIFs) do not exceed 3. Although we conclude that multicollinearity is not likely to be an issue, we use step-wise regressions to learn about the interrelationships among the independent variables. Table 4 shows the results of pooled OLS regressions with respect to new-to-the-market innovation (standard errors are clustered). The empirical analysis is conducted in four steps with four representative models. Model I is the baseline model, which includes the macro-economic control variables and the year dummies. This model explains 13% of the variation in new-to-themarket innovation (our dependent variable). In Model II, the knowledge variable is added to the baseline model to test the effect of knowledge on new-to-the-market innovation. As expected, a higher share of knowledge-intensive firms leads to a higher share of new-to-the-market innovations (β=0.27, p<0.1). The positive relationship of knowledge and new-to-the-market innovation increases the explanatory power of the model by 9% and confirms that the stock of knowledge is an important determinant of innovation performance. Model III includes the entrepreneurship variable in the model and shows that the rate of entrepreneurship itself does not seem to affect new-to-the-market innovation (β=0.09, p=0.67). The effect of the knowledge variable hardly increases, from β=0.27 (p<0.10) in Model II to β=0.31 (p<0.05) in Model III. Model IV tests the moderation effect of entrepreneurship, and the interaction term shows a positive effect (β=0.07, p<0.05). The explanatory power increases by 7%, from R²=22% in Model III to R²=29% in Model IV. A higher rate of entrepreneurship seems to increase the rate by which knowledge leads to new-to-the-market innovations, indicating that a higher rate of entrepreneurship facilitates the commercialization of knowledge. Entrepreneurship is found to moderate the relationship between knowledge and new-to-the-market innovation. To determine whether the OLS model produces consistent results, we perform a Breusch-Pagan test for random effects (Breusch and Pagan, 1980). The test shows significant results for Models I-II and insignificant results for Models III-IV. Thus, we conclude that the OLS coefficients are consistent in Models III-IV and inconsistent in Models I-II.

Pooled OLS regressions of new-to-the-firm innovation
As a further test of the role of entrepreneurship, we investigate whether entrepreneurship does not moderate the relationship between knowledge and new-to-the-firm innovation. Table 5 presents the results of the regressions with respect to new-to-the-firm innovation and shows that knowledge clearly leads to a higher share of new-to-the-firm innovations. A higher rate of knowledge-intensive firms increases turnover with new-to-the-firm products (β=0.51, p<0.05, Model II). However, Table 5 also shows that entrepreneurship does not have an effect with regard to new-to-the-firm products. Neither the entrepreneurship variable included directly (β=-0.29, p=0.13, Model III) nor the interaction term (β=-0.02, p=0.65, Model IV) shows significant results. Thus, a higher rate of entrepreneurship does not lead to more new-to-the-firm products. This result confirms our proposition that entrepreneurship moderates the relationship between knowledge and new-to-the-market innovation but does not impact the relationship between knowledge and new-to-the-firm innovation. The results should be interpreted with caution because the Breusch-Pagan test for random effects (Breusch and Pagan, 1980) yields significant results. OLS coefficients may be inconsistent; therefore, we also estimate random-and fixedeffects regressions (see below for robustness checks).

Further results from the regressions
Our analysis yields several other interesting findings. First, there seems to be a positive time trend for new-to-the-market innovations (ß=1.18, p<0.01, Table 4, Model III) and a negative time trend for new-to-the-firm innovations (ß=-3.57, p<0.01, Table 5, Model III). The ratio of 'true' innovation versus imitative innovation has increased over time in the 21 European countries. This phenomenon is one of the many indicators of the switch from a 'managed' to an 'entrepreneurial' economy Thurik, 2000, 2001). Second, the regressions for newto-the-firm innovation have higher R² values than the regressions for new-to-the-market innovation (R²=61% vs. 29% in Model IV) because of the effect of the year dummies. The inclusion of year dummies explains 42% of the variation in new-to-the-firm innovation but explains only 5% of the variation in new-to-the-market innovation. The autonomous decline in new-to-the-firm innovation seems to override the autonomous increase in new-to-the-market innovation. This phenomenon is one of many indicators of a decline in the competitiveness of European countries. Finally, the finding that knowledge plays a role in both new-to-the-market innovation (ß=0.27, p<0.1, Table 4, Model II) and new-to-the-firm innovation (ß=0.51, p<0.05, Table 5, Model II) supports our expectations and shows that investments in knowledge increase a country's level of absorptive capacity (Cohen and Levinthal, 1989), which has an effect on both types of innovation.

Robustness checks
To check the robustness of our results, we estimate random-and fixed-effects models (see Tables 6 and 7). Both models confirm our main finding that entrepreneurship moderates the relationship between knowledge and new-to-the-market innovation (Table 6: Model II: β=0.07, p=0.03; Model IV: β=0.12, p=0.01), but the models indicate no relationship between knowledge and new-to-the-firm innovation (Table 7: Model II: β=-0.04, p=0.46). A Hausman specification test is used to compare the coefficients of the random-and fixed-effects regressions (Hausman, 1978). In all estimations, the test shows an insignificant result (p>0.10) because the coefficients of the random-effects model do not differ systematically from the coefficients of the fixed-effects model. Nevertheless, the fact that our results also hold for a fixed-effects specification is important. We conclude that our main findings hold irrespective of country-specific variables such as openness to trade or geographic location.
As a further robustness check, we include the share of small firms (calculated from CIS data) as a control in our regression models. Because entrepreneurship is often related to small firms, our findings could also suggest that small firms face relatively lower costs of experimentation than do large firms. Potential losses from innovation at small firms have a lower limit than at larger firms (Jovanovic, 1982). In addition, small firms may have an advantage because it is easier for them to reward their employees for high-value innovation (Wiggins, 1995). As another robustness check, we include the share of venture capital investment in GDP (calculated from the annual yearbook of the European Venture Capital Association, EVCA) in our regressions because research by Kortum and Lerner (2000) shows that venture capital firms have a strong influence on innovation. After including these additional controls, our primary results remain unchanged, and the explanatory power of the respective regressions increases slightly. As a further robustness check, we experiment with alternative knowledge variables. To this end, we first regress the two alternative OECD knowledge measures (gross domestic expenditure on R&D and business expenditure on R&D) on our knowledge variable. We include the residuals of these regressions into the new-to-the-market and new-to-the-firm innovation regressions. This not only avoids the dangers of multicollinearity but also includes the additional effect of the two alternative OECD measures. The interaction term between entrepreneurship and knowledge remains significant and has a similar magnitude (new-to-the-market innovation regression) when compared to the analyses without the newly introduced variables (i.e., the residuals of a regression of the alternative OECD measures on our knowledge variable). The newly included residual variables have non-significant effects.
Finally, we estimate seemingly unrelated regression models (SUR) and two-stage simultaneous equation models in which the entrepreneurship variable is treated as endogenous. The moderation effect of entrepreneurship on the relationship between knowledge and innovation performance is similar to the effects in the other models. The estimation results relating to the robustness checks are available from the authors upon request.

Innovation in the knowledge spillover theory of entrepreneurship
Both the endogenous growth theory and the R&D capital approach point to knowledge as a major driver of economic growth. Less is known about the exact mechanism how knowledge affects growth. Thus, it is difficult for policymakers to identify policy instruments to promote growth. Glaeser et al. (1992) have established that knowledge and ideas do not spill over automatically; in the context of cities, at least, competition and diversity are required to generate growth (Audretsch, 1995;Audretsch and Feldman, 1996;Acs and Armington, 2004). The finding that knowledge does not automatically spill over has given rise to the concept of the knowledge filter, the group of impediments that prevent knowledge from spilling over from the site where it is created to the site where it can be commercialized. Independently of the investigation of the role of knowledge, a different strand of literature emphasizes the role of entrepreneurship in economic growth. The development of this literature culminates in the view that the older 'managed' economy has been replaced by a newer 'entrepreneurial' economy Thurik, 2000, 2001). The view that entrepreneurship is an independent production factor like human, physical and knowledge capital has led to the introduction of entrepreneurship capital into the production function (Audretsch and Keilbach, 2004). Various studies have shown that entrepreneurship influences economic growth (Parker, 2009;Erken et al., 2009). Although there are many indications in the knowledge literature that the (spatial) organization of business has an effect (Audretsch and Feldman, 1996;Anselin et al., 1997;Keller, 2002) and indications in the entrepreneurship literature that knowledge and its diffusion are important (Audretsch and Thurik, 2001), only the knowledge spillover theory of entrepreneurship unites these strains of thought , giving rise to its description as a "missing link" . Our paper uses the knowledge spillover theory of entrepreneurship to analyze the effect of entrepreneurship on the commercialization of knowledge leading to different innovation outcomes. Knowledge and entrepreneurial activity may ultimately lead to economic growth, but only by first producing innovative products. This link is addressed in the present paper using a panel dataset for the aggregate innovation activity of 21 European countries collected in four time waves. Our results clearly show that entrepreneurship moderates the relationship between knowledge and new-to-the-market innovation but has no impact on the relationship between knowledge and new-to-the-firm innovation. In other words, our results show that countries with a high rate of entrepreneurship perform better in terms of what is sometimes referred to as 'true' innovation (Kleinknecht et al., 2002).
Figure 1 illustrates our conceptual model. The production of knowledge increases the aggregate stock of knowledge (arrow 1). Both existing firms and new firms can draw from this aggregate stock and develop both new-to-the-firm (arrow 2) and new-to-the-market products (arrow 3). 10 Entrepreneurship moderates the relationship between the aggregate stock of knowledge and the number of new-to-the-market products ('true' innovation performance) (arrow 4), but it has no impact on the relationship between the aggregate stock of knowledge and the number of imitative products. 11 Both new-to-the-firm, imitative products and new-to-the-market products may lead to economic growth. However, the mechanisms involved differ and may depend on the country's level of development (Vandenbussche et al., 2006). We will not expand upon this discussion because it is beyond the scope of our paper. 10 Consider the following example: firm A discloses new knowledge (e.g., by filing a patent). Firm B applies this new knowledge to create a product that is similar to the product idea of firm A (which leads to an imitative product). Firm C, however, uses this new knowledge to create a product that is new to both firm A and firm B (which leads to an innovative product).

11
A different mechanism is suggested by Audretsch, Boente and Keilbach (2008), where innovation efforts are assumed to generate technical knowledge and entrepreneurship capital, and the latter two are assumed to lead to economic growth.

Schumpeterian explanation for the moderating role of entrepreneurship
Our findings concerning the role of entrepreneurship are consistent with a Schumpeterian view of entrepreneurship and innovation. Schumpeter divided the creative process of economic development into three stages: invention, innovation (commercialization) and imitation. In his early works, Schumpeter argued that entrepreneurs are not necessarily inventors or knowledge creators (Schumpeter, 1934); instead, they transform knowledge into products (Brouwer, 2002). That is, entrepreneurs are innovators who introduce new products, create new production methods and open new markets. Schumpeter saw the entrepreneur as an agent who can cope with uncertainty, thereby inducing technological change and progress (Brouwer, 2002). Therefore, entrepreneurs should be more effective than other agents at successfully commercializing inventions. Braunerhjelm and Svensson (2010) show that the likelihood of the commercial success of an invention increases significantly when the invention is commercialized by an entrepreneur rather than by an inventor. Our findings regarding the role of entrepreneurship clearly support a Schumpeterian view of entrepreneurship and innovation. Entrepreneurship moderates the relationship between a country's level of knowledge and new-to-the-market innovation but has no impact on the relationship between knowledge and new-to-the-firm innovation. The former relationship is characterized by a high degree of uncertainty, whereas the latter may not be. The entrepreneur's capacity for risk taking and absorbing uncertainty is more important with new-to-the-market innovation than with new-to-the-firm innovation. The moderating role of entrepreneurship in new-to-the-market innovation is related to the level of product complexity in the manufacturing sector. With increasingly complex products and production processes, imitation is hardly a feasible way for new firms to enter the manufacturing sector (Hobday, 1998). A firm's chances of survival increase when it has 'true' innovations. Successful market entry by entrepreneurs requires the ability to turn knowledge into innovation.

Implications for innovation and entrepreneurship policy
Our main finding, that entrepreneurship moderates the relationship between knowledge and 'true' innovation performance, has important policy implications. From an innovation policy perspective, promoting the production of new knowledge (e.g., by means of R&D subsidies or university education) is not sufficient; it is equally important for entrepreneurs to turn this new knowledge into innovative products to fuel economic growth. If there are only a few entrepreneurs in a knowledge-intensive region, the so-called Swedish or European paradox (Ejermo and Kander, 2006;Audretsch, 2007) may emerge, with the implication that commercial opportunities will remain under-exploited or will only be exploited outside the region. In any case, profits will not flow back to the region in which the knowledge was produced. To prevent this situation, policymakers may want to promote entrepreneurship in their own country or region through subsidized loans to high-tech entrepreneurs, regulatory exemptions for innovative new start-ups, or tax benefits. However, we believe that simply encouraging more people to become entrepreneurs is not an effective policy. The government should support those entrepreneurs who take the risk of transforming new knowledge into innovative products and focus less on those entrepreneurs who merely start another shop around the corner . 12 Many start-ups do not fall into the first category but belong to the latter group (Block, Sandner, Spiegel, 2010;Koellinger, 2008).
In fact, prior research shows that many entrepreneurs start their venture out of economic necessity (Block and Sandner, 2009;Block and Wagner, 2010). An alternative long-term strategy for policymakers would be to promote (entrepreneurship) education to increase the number of qualified and risk-taking entrepreneurs (Block, Hoogerheide, and Thurik, in press). 12 See also Shane (2009), who discusses at length why simply encouraging more people to become entrepreneurs is a bad public policy.

Limitations and further research
Our paper has limitations in the scope of the dataset and the measurement of innovation. These limitations suggest opportunities for further research.
Regarding the first limitation, our dataset is limited to the countries participating in the CIS. An extension of the dataset to emerging countries in Asia or Latin America would be interesting. Given prior research about the role of entrepreneurship in emerging economies (Naudé, 2011), we would expect the positive effects of entrepreneurship in the commercialization of knowledge into innovations to be even greater. As noted above, the dataset of the GEM (Reynolds et al., 2005) and the recently developed Global and Entrepreneurship Development Index (GEDI, Acs and Szerb, 2011) could be used as a source of entrepreneurship data. The difficulty is in finding comparable country-level data about innovation activities that goes beyond information about aggregated levels of R&D spending.
In terms of measuring innovation, our paper is limited to two specific types of innovation, new-to-the-market and new-to-the-firm innovation. However, the concept of innovation has many different facets and dimensions (Kleinknecht et al., 2002). For example, we would expect entrepreneurship to have a greater effect with regard to radical versus incremental innovation (Arrow, 1962). Research by Henderson (1993) suggests that established firms are more likely than entrants to invest in incremental innovation. In addition, incumbent firms seeking to exploit radical innovation are significantly less productive in their research efforts than new firms entering the market.
In addition to the differences between incremental and radical innovation, there may be industry-specific and technology-specific patterns in the role of entrepreneurship with respect to the transformation of knowledge into commercial products. Prior research on the distinction between Schumpeter Mark I and Schumpeter Mark II industries, for example, suggests that the determinants of innovation may be industry-and technology-specific (Breschi et al., 2000;Malerba and Orsenigo, 1995).

Concluding remarks
Additional research is needed to determine how to identify, attract, and support those entrepreneurs who transform knowledge into 'truly' innovative products and thereby increase the competiveness of their particular region. Some questions worth investigating include the following: What types of entrepreneurs turn knowledge into new products (inexperienced versus experienced entrepreneurs)? How should these entrepreneurs be funded (equity versus debt)? What role do VCs and their specific social capital play in the commercialization process? 13 How does the path to entrepreneurship (e.g., business takeover versus new venture start? 14 ) influence the entrepreneur's ability to turn knowledge into innovation? What is the role of technology clusters and government-sponsored technology parks with respect to the relationship between entrepreneurship and innovation?
The stagnation of competitiveness in European economies is often attributed to their inability to transform new knowledge into commercially viable products. Policymakers have persistently believed that entrepreneurs play a larger role in this transformation than do large corporations. A wave of policies focusing on the promotion of entrepreneurship has ensued, and the present analysis shows that this policy trend is justified. 13 See Alexy et al. (in press) for a discussion of the social capital of VCs. 14 See Block, Thurik, Van der Zwan, and Walter (in press) for a discussion of business takeover versus new venture start.  CIS question: "What is the percentage of total turnover from goods and service innovations introduced during the last three years that were new to the market?" The question was included in CIS2 (1996( ), CIS3 (1998, CIS4 (2002), and CIS2006 (2004-2006. Community Innovation Survey: CIS2, CIS3, CIS4, and CIS2006 (only answers from manufacturing firms) New-to-the-firm innovation (in %) CIS question: "What is the percentage of total turnover from goods and service innovations introduced during the last three years that were new to the firm?" The question was included in CIS2 (1996( ), CIS3 (1998, CIS4 (2002), and CIS2006 (2004-2006 CIS question: "During the last three years, did your enterprise apply for a patent?" The question was included in CIS2 (1996)(1997)(1998), CIS3 (1998CIS3 ( -2000, CIS4 (2002), and CIS2006 (2004-2006. The variable is calculated as the number of firms that answered 'yes' as a percentage of the total number of firms. Community Innovation Survey: CIS2, CIS3, CIS4, and CIS2006 (only answers from manufacturing firms)