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Probiotics and sepsis: separating the signal from the noise

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Availability of data and material

Requests for data should be made to the corresponding author. Each request requires a research proposal including a clear research question and proposed analysis plan. Requests will be considered on an individual basis and are subject to review and approval by the ROCIT management committee and relevant human research ethics committees.

Code availability

Requests for code should be made to the corresponding author and will be considered on an individual basis by the study management committee.

References

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Acknowledgements

The authors would like to thank the ROCIT participants and the consumers from the Consumer and Community Involvement Program (The University of Western Australia, MBDP M503, 35 Stirling Highway, Crawley, WA, 6009) for their contribution to the study design. The members of the ROCIT investigators are: Edward Litton PhD1,2,3, Matthew H Anstey MPH3,4, David Broadhurst PhD5, Andy Chapman MBBS6, Andrew Currie PhD7, Janet Ferrier BSc2, Joel Gummer PhD8, Alisa Higgins PhD9, Jolene Lim MPH1, Laurens Manning PhD10, Erina Myers BN4, Katrina Orr BPharm11, Anne-Marie Palermo RN1, Andrea Paparini PhD12, Susan Pellicano RN1, Edward Raby MBBS10, Anu Rammohan PhD13, Adrian Regli MD1,14, Bernhard Richter MD1,15, Sam Salman PhD3, Tobias Strunk PhD16, Sharon Waterson RN6, David Weight BSc1, Bradley Wibrow MSc4, and Fiona Wood MBBS17

Funding

ROCIT is funded by grants from the Department of Health, Government of Western Australia Research Translation Projects, the St John of God Hospital Foundation, and the Fiona Wood Foundation. Study drug was supplied by Metagenics Australia (previously Health World), 741 Nudgee Road, Northgate, Queensland 4013, Australia. The funding bodies and Metagenics Australia have had no input into the design, conduct, analysis or reporting of the trial. The study sponsor is the Fiona Stanley Fremantle Hospital Group, South Metropolitan Health Service, Western Australia.

Author information

Authors and Affiliations

  1. Intensive Care Unit, Fiona Stanley Hospital, Murdoch, 6150, Australia

    Edward Litton

  2. Intensive Care Unit, St John of God Hospital, Subiaco, 6009, Australia

    Edward Litton

  3. School of Medicine, University of Western Australia, Crawley, 6009, Australia

    Edward Litton

  4. Molecular and Forensic Sciences, Murdoch University, Perth, 6150, Australia

    Andrew Currie

  5. Infectious Diseases, Fiona Stanley Hospital, Murdoch, 6150, Australia

    Edward Raby

Authors
  1. Edward Litton
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  2. Andrew Currie
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  3. Edward Raby
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Consortia

the ROCIT Investigators

  • Edward Litton
  • , Matthew H. Anstey
  • , David Broadhurst
  • , Andy Chapman
  • , Andrew Currie
  • , Janet Ferrier
  • , Joel Gummer
  • , Alisa Higgins
  • , Jolene Lim
  • , Laurens Manning
  • , Erina Myers
  • , Katrina Orr
  • , Anne-Marie Palermo
  • , Andrea Paparini
  • , Susan Pellicano
  • , Anu Rammohan
  • , Adrian Regli
  • , Bernhard Richter
  • , Sam Salman
  • , Tobias Strunk
  • , Sharon Waterson
  • , David Weight
  • , Bradley Wibrow
  •  & Fiona Wood

Contributions

EL, wrote the first draft of the letter, AC and ER contributed to critical revisions.

Corresponding author

Correspondence to Edward Litton.

Ethics declarations

Conflicts of interest

The authors report no conflicts of interest.

Ethics approval

The ROCIT protocol was prospectively approved by the human research ethics committee of all participating institutions and reported prior to completion of the study. This was the South Metropolitan Health Service Human Research Ethics Committee ref:RGS000004, and the St John of God Health Care Human Research Ethics Committee ref:1183.

Consent to participate

Consent to participate was provided prospectively from all participants or their legal surrogate.

Consent for publication

The signed consent forms for all participants included consent to publication of aggregate data. The authors all consent to publication of the manuscript.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

The members of “on behalf of the ROCIT Investigators” is present in the Acknowledgements section.

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Litton, E., Currie, A., Raby, E. et al. Probiotics and sepsis: separating the signal from the noise. Intensive Care Med 47, 924–925 (2021). https://doi.org/10.1007/s00134-021-06427-w

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  • DOI: https://doi.org/10.1007/s00134-021-06427-w

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