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Parkinson-Krankheit

Parkinsonʼs disease

  • Schwerpunkt: Neurodegenerative Erkrankungen
  • Published:
Die Innere Medizin Aims and scope Submit manuscript

Zusammenfassung

Die Parkinson-Krankheit (PK) ist das eindrücklichste Beispiel für eine effektiv therapierbare neurodegenerative Erkrankung mit lang anhaltender stabiler Symptomkontrolle und Lebensqualität. Der Zusammenarbeit von Neurologen mit Hausärzten, Gastroenterologen und Geriatern kommt immer größere Bedeutung zu. Neue Diagnosekriterien für die PK, aber auch für differenzialdiagnostisch zu erwägende atypische Parkinson-Syndrome beziehen nichtmotorische Symptome ein und haben das Ziel der möglichst frühen Diagnosestellung. Auf allen Ebenen des Gastrointestinaltrakts bestehen hochkomplexe Interaktionen mit der PK, die in den letzten Jahren immer besser verstanden wurden und unmittelbare klinische Relevanz haben. Neue dopaminerge Therapieoptionen fokussieren auch auf eine Umgehung des gestörten Gastrointestinaltrakts. Das Management der PK bei geriatrischen Patienten sowie der Parkinson-Demenz erfordert spezifisches Wissen. Die PK ist weltweit eine Modellkrankheit für die Entwicklung von Netzwerkstrukturen zur Versorgung chronisch-neurologischer Erkrankungen.

Abstract

Parkinson’s disease (PD) is an unparalleled example of a neurodegenerative disorder that can be effectively managed leading to sustained symptom control and quality of life. The cooperation of neurologists with general practitioners, gastroenterologists, and geriatricians is of increasing importance for an optimized management of PD. New diagnostic criteria for PD and for atypical Parkinsonism, which should be considered in the differential diagnostics, include non-motor symptoms and aim to diagnose these disorders as early as possible. Recent research has shown that there are highly complex and clinically relevant interactions with PD at all levels of the gastrointestinal tract, which have been increasingly better understood and have direct clinical relevance. Novel dopaminergic treatment approaches focus on circumvention of the impaired gastrointestinal tract of PD patients. The management of geriatric PD patients and PD dementia requires specific clinical knowledge. Worldwide, PD has emerged as a model disease for the development of network structures for the treatment of chronic neurological diseases.

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Authors and Affiliations

  1. Klinik für Neurologie und Neurologische Frührehabilitation, Klinikum Osnabrück, Am Finkenhügel 1, 49076, Osnabrück, Deutschland

    Tobias Warnecke

  2. Privates Institut für angewandte Versorgungsforschung (inav), Schiffbauerdamm 12, 10117, Berlin, Deutschland

    Carina Lummer

  3. Medizinische Klinik II für Gastroenterologie, Klinikum Osnabrück, Am Finkenhügel 1, 49076, Osnabrück, Deutschland

    Johannes Wilhelm Rey

  4. Klinik für Neurologie, Universitätsklinikum Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Deutschland

    Inga Claus

  5. Klinik für Geriatrie und Palliativmedizin, Klinikum Osnabrück, Am Finkenhügel 1, 49076, Osnabrück, Deutschland

    Dieter Lüttje

  6. Parkinson-Zentrum Münster-Osnabrück (PaMOS), Münster-Osnabrück, Deutschland

    Tobias Warnecke & Inga Claus

  7. Zentrum für Parkinson-Syndrome und andere Bewegungsstörungen (ZPSB), Klinikum Osnabrück, Am Finkenhügel 1, 49076, Osnabrück, Deutschland

    Tobias Warnecke & Dieter Lüttje

Authors
  1. Tobias Warnecke
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  2. Carina Lummer
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  3. Johannes Wilhelm Rey
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  4. Inga Claus
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  5. Dieter Lüttje
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Corresponding author

Correspondence to Tobias Warnecke.

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Interessenkonflikt

T. Warnecke hat Honorare erhalten von AbbVie, UCB, Archimedes, Phagenesis, Zambon, Bial und Kyowa für Beratertätigkeiten und von Bial, Britannia, AbbVie, STADA, UCB, Biogen, Licher, Desitin, Pfizer, Zambon, Teva und Bayer für Vortragstätigkeiten. C. Lummer, J.W. Rey, I. Claus und D. Lüttje geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autor/-innen keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

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Warnecke, T., Lummer, C., Rey, J.W. et al. Parkinson-Krankheit. Innere Medizin 64, 131–138 (2023). https://doi.org/10.1007/s00108-022-01444-3

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  • DOI: https://doi.org/10.1007/s00108-022-01444-3

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