Radiotherapy concepts for spinal metastases—results from an online survey among radiation oncologists of the German Society for Radiation Oncology

Purpose Spinal metastases (SM) are a common radiotherapy (RT) indication. There is limited level I data to drive decision making regarding dose regimen (DR) and target volume definition (TVD). We aim to depict the patterns of care for RT of SM among German Society for Radiation Oncology (DEGRO) members. Methods An online survey on conventional RT and Stereotactic Body Radiation Therapy (SBRT) for SM, distributed via e‑mail to all DEGRO members, was completed by 80 radiation oncologists between February 24 and April 29, 2022. Participation was voluntary and anonymous. Results A variety of DR was frequently used for conventional RT (primary: n = 15, adjuvant: n = 14). 30 Gy/10 fractions was reported most frequently. TVD in adjuvant RT was heterogenous, with a trend towards larger volumes. SBRT was offered in 65% (primary) and 21% (adjuvant) of participants’ institutions. A variety of DR was reported (primary: n = 40, adjuvant: n = 27), most commonly 27 Gy/3 fractions and 30 Gy/5 fractions. 59% followed International Consensus Guidelines (ICG) for TVD. Conclusion We provide a representative depiction of RT practice for SM among DEGRO members. DR and TVD are heterogeneous. SBRT is not comprehensively practiced, especially in the adjuvant setting. Further research is needed to provide a solid data basis for detailed recommendations.


Introduction
Spinal metastases are one of the common indications for radiotherapy (RT), given a prevalence of up to 50% [1] in cancer patients.RT of spinal metastases may be performed using conventional RT in palliative intent [2,3] although ablative treatment with Stereotactic Body Radiation Therapy (SBRT) in both palliative and potentially curative intent is being increasingly utilized [4][5][6].
The primary goal of conventional palliative RT is pain control.Various fractionation schemes are accepted and recommended, for instance 8 Gy in a single fraction, 20 Gy in 4 fractions and 30Gy in 10 fractions [5,[7][8][9].It is known, however, that RT schemes with higher biologically effective dose lead to improved long term tumor control [10,11].This is becoming increasingly important as survival in metastatic cancer patients increases due to modern effective systemic therapies.SBRT is a locally ablative therapy performed in the context of oligometastatic disease in a potentially curative scenario [6,12] and is also offered for pain control in the palliative setting [5,13].As in conventional palliative RT, dose schemes used in SBRT of spinal metastases show a considerable range of variation.Dose regimens used in large prospective studies range from 16 or 20 Gy in a single fraction [6,14] to 24Gy in 2 fractions [5], 30 Gy in 3 fractions or 35 Gy in 5 fractions [6].
Regarding target volume definition, a heterogeneity of contouring strategies exists.International Consensus Guidelines (ICG) for target volume delineation are available for primary and adjuvant SBRT [15][16][17], however, there is no uniform recommendation for palliative RT.This is crucial especially in the adjuvant setting, where surgical instrumentation and surgical tract might or might not be included in the target volume.
There is an ongoing interdisciplinary discussion between spine surgeons and radiation oncologists on the optimal sequence of RT for primary and secondary tumors, especially with respect to the potential impact of including all areas touched during surgery.For spinal metastases, the discussion questions the traditional and well-established concept of including all affected areas, vertebrae above and below the affected region, and the whole instrumentation, when applicable.
The aim of the survey was to provide a representative depiction of the patterns of care for spinal metastases from a radiation oncology perspective among members of the German Society for Radiation Oncology (Deutsche Gesellschaft für Radioonkologie e.V., DEGRO).The study aims to provide an overview of the daily practice in terms of dose prescription and target volume definition, as well as frequency of treatments and RT techniques used.

Materials and methods
The survey on RT treatment concepts for spinal metastases was developed by a team of radiation oncologists.All questions were specifically developed for the purpose of this investigation, and they were asked in German language.The questions were reviewed by experienced national and international radiation oncologists and a neurosurgeon specializing in radiosurgery, all members of the Spine Tumor Academy (STA).
The questionnaire (see Appendix for the original questionnaire and an English translation) consisted of four thematic sections: Conventional RT in primary (1) and postoperative, adjuvant (2) palliative intention as well as primary (3) and adjuvant (4) SBRT for spinal metastases.Participant-specific information was also obtained.The survey consisted of a total of 31 questions, three of which participant-specific (level of seniority, type of institution, country of practice), 16 related to conventional RT and 12 related to SBRT.Not all questions had to be answered by all participants: Participants from institutions where SBRT is not practiced answered a total of 20 questions, and participants at institutions where spinal SBRT is offered as primary treatment answered a total of 26 questions.The following types of questions were used: Short text, single choice and multiple choice.The questionnaire was available as an online survey at survio.com.Survio is an online platform for survey generation, powered by Survio s.r.o.(Brno, Czech Republik).The platform ensures data safety (ISO/IEC 27001 certificate, 2048-bit SSL security, ISO/IEC 270001 standards, daily backups).
A call for participation was sent via the DEGRO membership mailing list on February

Results
A graphical overview of the results on the participants of the survey can be found in Fig. 1.Most of the 80 participants (n = 72, 90%) have completed residency training
The three most important factors for determination of the dose regimen were general state of health (85%, n = 68), oncological prognosis (80%, n = 64) and the presence of Less than 50% of all participants considered the following items to be decisive for the dose regimen: Size of the lesion (48%, n = 38), proximity to organs at risk (44%, n = 35), tumor histology (41%, n = 33) and pain level of metastases (31%, n = 25).Patient-related scheduling reasons are among the most important factors for dose prescription for almost a third of all participants (29%, n = 23) and financial reimbursement was among the most important factors of influence for 5% (n = 4) of participants.Site-related scheduling (4%, n = 3) plays an important role in the determination of the dosage concept for individual participants of the survey.
RT treatment planning was CT based only in 56% (n = 45), whereas 44% (n = 35) of participants used CT and MRI for treatment planning.The most used irradiation technique for conventional adjuvant palliative RT was VMAT, with 68% (n = 54) of radiation oncologists applying it frequently, followed by 3D-RT (48%, n = 38), IMRT (26%, n = 21) and Tomotherapy (5%, n = 4).In those cases where participants were aware of the type of surgical material used for stabilization (n = 53), it was indicated that titanium implants were used in the vast majority of cases (n = 50; 94%).Three participants (6%) stated that carbon fiber implants are mostly used at their institution.
The influencing factors for determining the dose regimen are fairly similar to those for primary palliative RT.As K in conventional primary palliative RT, the top three factors were patient's general state of health (88%, n = 70), oncological prognosis (71%, n = 57) and whether a soft tissue component is present (56%, n = 45; see Fig. 3b).For more than a third of all participants, size of the lesion (48%, n = 38), proximity to organs at risk (44%, n = 35) and tumor histology (39%, n = 31) were among the most relevant factors.As for conventional primary palliative RT, patientrelated scheduling reasons were among the most important factors for dose prescription for almost a third of all participants (31%, n = 25).Pain level of metastases and financial reimbursement were among the most important factors of influence for 21% (n = 17) and 6% (n = 5) of participants, respectively.Site-related scheduling (1%, n = 1) played an important role in the determination of the dosage concept for one participant of the survey.
The majority of participants tended to use extended target volumes.Regarding the craniocaudal extent of the target volume, 49% (n = 39) of participants reported to regularly include all vertebral segments over which the surgical instrumentation extended.One quarter (n = 20) of participants indicated that they regularly define a smaller target volume including the vertebral segment above and below the affected vertebral segment, as well as the affected vertebral segment itself.11% (n = 9) of radiation oncologists routinely opted for an even more reduced target volume including the affected vertebral body only.All vertebral bodies in the region of the instrumentation affected by metastases were systematically included in the target volume by 49% (n = 39).One participant specified an individual response, stating that the craniocaudal extent of the target volume depended on the radiological appearance/histology, including coverage of all vertebral segments over which the surgical instrumentation extended for lytic metastases, and one vertebral segment above and below the affected vertebral segment, as well as the affected vertebral segment itself in case of non-lytic metastases.
As with the definition of the craniocaudal extent of treatment volumes, there was no uniform approach to target volume delineation regarding the inclusion of surgical instrumentation and track.45% (n = 36) of participants reported they regularly included the entire surgical instrumentation (screws and rods) outside of the bone tissue.A systematic inclusion of the entire surgical tract dorsal to the vertebral body/bodies in the target volume was performed by 24% (n = 19) of radiation oncologists.43% (n = 34) of participants reported they included neither the surgical instrumentation outside of the bone tissue nor the entire surgical tract dorsal to the vertebral body/bodies.One participant specified that the approach in treatment volume delineation depended on the method of surgery, stating that the whole instrumentation was included, except when pedicle screws were implanted percutaneously in non-affected vertebral segments.In the latter case, the one participant stated to not include the instrumentation in the target volume.
The heterogeneous responses regarding target volume definition in conventional adjuvant palliative RT were somewhat suspected by us in advance, given the lack of specific guidelines.In this context, and given the fact that we are currently preparing a prospective trial on target volume delineation in this therapy situation at our institution, we asked whether patients could currently be enrolled in a prospective study at the institution of the survey participant.All participants replied that they had no possibility to enroll patients in a prospective trial on conventional adjuvant palliative RT at their institution.
Radiooncological follow-up of patients with spinal metastases treated with RT in a palliative intention was not consistently offered.Regular follow-up was carried out by 69% (n = 55) of participants.Follow-up was performed in case of new complaints in 23% (n = 18).The following responses were provided by individual participants only: Scheduling of follow-up visits depending on the general state of health and/or patient's prognosis (4%, n = 3), no radiooncological follow-up (3%, n = 2), a single radiooncological follow-up visit three months after palliative RT (1%, n = 1) and radiooncological follow-up in cooperation or coordination with the clinic primarily responsible for the oncologic treatment of the patient (1%, n = 1).

Section 3-SBRT in primary intention
Primary SBRT i.e., without prior surgical intervention, was offered at 65% (n = 52) of participant's institutions.For university hospitals, this was indicated in 93% (n = 25), for non-university hospitals in 50% (n = 9) and for medical practices/ambulatory health care in 49% (n = 15) of responses.
SBRT for spinal metastases was much less frequently carried out than palliative RT.Of the radiation oncologists stating that primary SBRT is offered at their institution, a majority of 87% (n = 45) reported annual patient numbers of 1-50, 12% (n = 6) indicated 51-100 and 2% (n = 1) reported 500.
Treatment planning was CT-and MRI-based in most cases (73%, n = 38).However, 27% (n = 14) of participants stated to perform primary SBRT CT-based only.PET, if applicable, was used in addition to CT and MRI for target volume definition by three radiation oncologists (6%).Participants at institutions where SBRT for spinal metastases was performed mostly (94%, n = 49) reported using a linear accelerator for this purpose.Three (6%) radiation oncologists indicated to regularly use a Cyberknife (Accuray, Sunnyvale, CA, USA).Of these, two reported using a Cyberknife exclusively for SBRT of spinal metastases.

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Specific dose regimens regularly used for primary SBRT were reported by 47 participants.As many as 40 regimens for dose prescription, both without and with simultaneous integrated boost (SIB), were reported, ranging from singlefraction SBRT to as many as 16 fractions (for full list of reported dose regimens, see Appendix Table 2).30 (64%) radiation oncologists specified one regimen that they used most often.In the other cases (n = 17, 36%), several dose regimens were reported.15 dose regimens were identified that were mentioned by more than one participant (see Fig. 2c).The dose regimens most frequently mentioned  25 Gy in 5 fractions and 30 Gy in 6 fractions (n = 3, 6% each).In three cases, additional information on prescription isodoses was provided.The respective treatment concepts were: 25 Gy in 5 fractions prescribed to the 60% isodose line encompassing the planning target volume (PTV), 30 Gy in 5 fractions prescribed to the 80% isodose line and 25 Gy in 5 fractions plus SIB with 6-8 Gy single dose prescribed to the 65-80% isodose line encompassing the gross tumor volume (GTV) + 5 mm.Among the most reported reasons for selecting the dose regimen in primary SBRT, as reported by 50 participants, were therapy goal i.e., palliation vs. ablation of oligometastasis with a curative intent (n = 42, 84%), proximity to organs at risk (n = 40, 80%) and size of the lesion (n = 39, 78%, see Fig. 3c).For more than half of the participants whose institution offered SBRT (n = 31, 62%), oncological prognosis was an important decision criterion in dose determination.Other important factors included presence of soft tissue component (n = 24, 48%), tumor histology (n = 23, 46%) and vertebral body fracture risk (n = 20, 40%).Reimbursement was an important factor of influence for four (8%) participants.
Fifteen out of 49 (31%) radiation oncologists who delivered primary SBRT stated they did not follow specific contouring recommendations.By far the most followed ICG (n = 29, 59%) were the International Spine Radiosurgery Consortium consensus guidelines for target volume definition in spinal stereotactic radiosurgery [15].Target volume definition according to the DOSIS trial [18] was performed by 8% (n = 4).The following contouring recommendations for primary SBRT were mentioned by individual participants: International consensus recommendations for target volume delineation specific to sacral metastases and spinal stereotactic body radiation therapy (SBRT) [17], SABR-COMET trial [6], RTOG 0631 trial [14] and SPIN-MET trial [19] (n = 1 each).One participant specified to contour the lesion only plus PTV for small metastases.A tabular overview of the publications mentioned, including the respective recommendations, can be found in Table 1.ICG for adjuvant SBRT i.e., Consensus Contouring Guidelines for Post-Operative Stereotactic Body Radiation Therapy (SBRT) for Metastatic Solid Tumor Malignancies to the Spine [16] were also mentioned in this context.

Section 4-SBRT in adjuvant intention
A minority of 17 (21%) participants indicated that SBRT in adjuvant intention was carried out at their institution.This was reported for university hospitals by 33% (n = 9), for non-university hospitals by 11% (n = 2) and for medical practices/ambulatory health care by 17% (n = 17) of participants.
Fifteen participants indicated most frequently used dose regimens, resulting in a total of 27 different regimens reported.The indicated dose regimens ranged from singlefraction SBRT to as many as 20 fractions, and as in primary SBRT, both regimens with and without SIB were reported.9 (60%) radiation oncologists indicated one specific dose regimen they used most for adjuvant SBRT.The other six (40%) participants reported two or more regimens they frequently used.Only one dosing regimen was mentioned twice, namely 30 Gy in 10 fractions plus SIB with 48.5 Gy in 10 fractions.All other schemes, for which an overview can be found in Appendix Table 3, were reported only once.Two participants provided additional information on dose prescription i.e., 25 Gy in 5 fractions prescribed to the isodose line encompassing PTV and 30 Gy in 5 fractions prescribed to the 80% isodose line.
The factors of influence on the dose regimen are fairly similar to those for primary SBRT (see Fig. 2d).In adjuvant SBRT therapy goal i.e., palliation vs. ablation of oligometastasis with curative intent (n = 14, 82%), proximity to organs at risk (n = 13, 76%) and size of the lesion (n = 14, 82%) were also identified as the three most important ones.For more than half of radiation oncologists at whose institution adjuvant SBRT was performed, factors including presence of soft tissue component and vertebral body fracture risk (n = 10, 59%) were also among the most important factors influencing the dose regimen.Other factors mentioned were oncological prognosis (n = 8, 47%) and tumor histology (n = 7, 41%).
Thirty-five percent (n = 6) indicated that they did not follow any specific guidelines for target volume delineation in adjuvant SBRT.A majority of 52% (n = 9) of participants specified to consider the Consensus Contouring Guidelines for Post-Operative Stereotactic Body Radiation Therapy (SBRT) for Metastatic Solid Tumor Malignancies to the Spine [16] for target volume delineation.One participant reported to contour in analogy to the DOSIS trial [18] in addition to the beforementioned Consensus Contouring Guidelines.Another participant stated to use recommendations for target volume definition of the RTOG 0631 [14] trial.Both studies contain target volume contouring strategies for primary SBRT, and it remains unclear to what extent participants extrapolate these to the adjuvant setting.

Discussion
Palliative RT of spinal metastases is a frequently performed therapy.Accordingly, participants reported considerable experience.This is particularly true for primary palliative RT, K where most participants (64%) reported an annual patient volume of more than 50.There was also a considerable number of participants working in centers with a large number of patients with annual case numbers of 300 or more (n = 11 for primary and n = 6 for postoperative palliative RT), reflecting their expertise in this field.
Overall, our survey indicates that many different treatment regimens are used and that standardized guidelines are warranted.The study identified most commonly used dose regimens i.e., 30 Gy in 10 fractions, 20 Gy in 5 fractions, 35 Gy in 14 fractions and 36 Gy in 12 fractions, reported by > 20% of participants.Factors influencing the choice of dose regimen in conventional primary and adjuvant RT were nearly identical in rank order, with the top three items being patient's general state of health, oncological prognosis, and soft tissue component present.Tumor histology was reported to only play a minor important role in determining the dosage regimen (for primary and adjuvant RT 41% and 39%, respectively).This is in line with data showing no significant improvement in local control at one year with doses beyond 30 Gy in 10 fractions for radioresistant tumors [20].The pain level of the bone metastases also did not play an important role in dose determination (for primary and adjuvant RT 31% and 21%, respectively), in line with data showing a sufficient pain response for various dose schemes [10].RT technique ap-pa (for primary and adjuvant RT 1% and 0%, respectively 1/0%) seems almost completely obsolete, whereas 3D-RT still plays a relevant role in conventional RT (for primary and adjuvant RT 50% and 48%, respectively).
Target volume definition in conventional adjuvant RT was heterogenous, with a tendency towards extended treatment volumes.All vertebral segments over which the surgical instrumentation extended were included by 49%, and the entire surgical instrumentation (screws and rods) outside of the bone tissue were included by 45% of participants.However, 43% included neither the surgical instrumentation outside of the bone tissue nor the entire surgical tract dorsal to the vertebral body/bodies, but only 11% routinely including the affected vertebral body only.There are no guidelines for target volume definition in conventional adjuvant RT, and the heterogeneity in responses regarding strategies in target volume delineation were therefore to some extent expectable.To provide a solid data basis for contouring recommendations in this situation, patternsof-failure analyses are required.One prerequisite for such analyses would be systematic radiation oncology follow-up visits, as offered by 69% of participants.Prospective studies would also be very desirable to provide further evidence regarding target volume definition.A prospective study in this regard is currently not performed at any institution of the participants of this survey.However, we are currently preparing a prospective trial on conventional adjuvant RT comparing larger with reduced treatment volumes with regard to local tumor control.
The survey showed that a majority of institutions (65%) offers SBRT for spinal metastases.However, patients do not have access to SBRT in every institution, and it is especially limited in the adjuvant setting, where only 21% of participants report to perform it at their institution.The lack of widespread availability of SBRT in the adjuvant setting may impose further consequences in individual cases.It is possible that in the absence of adjuvant SBRT, conventional RT may be utilized, or that it might also needs to be considered regarding the surgical approach (decompression and stabilization vs. favor of en-bloc resection, when adjuvant SBRT is not available).
In primary SBRT, there is a great variability of dose concepts (for primary and adjuvant SBRT n = 40 and 27, respectively) that were utilized, with 15 regimens being applied by two or more participants.The most frequently mentioned regimens were 30 Gy in 5 fractions, 27 Gy in 3 fractions, 25 Gy in 5 fractions plus SIB with 40 Gy in 5 fractions, 30 Gy in 10 fractions plus SIB with 48.5 Gy in 10 fractions and 35 Gy in 5 fractions.While SIB concepts are being administered in palliative RT by a small number of participants, they have a greater relevance in daily practice of SBRT.It is unclear as to why some of the regimens applied both in the primary and adjuvant setting were reported using a stereotactic approach e.g., 12 Gy in 3 fractions, 20 Gy in 5 fractions, 30 Gy in 10 fractions or 37.5 Gy in 15 fractions.However, this manuscript presents all responses as received.The factors influencing the choice of dose regimen were clearly different in SBRT compared to conventional RT, with top three items being therapy goal (palliation vs. ablation of oligometastasis with a curative intent), proximity to organs at risk and size of the lesion.In contrast to conventional RT, time and, secondarily, reimbursement did not play a relevant role.The finding that therapy goal was the most important influencing factor for dose prescription in SBRT might seem surprising, as SBRT is known to be effective both as ablative therapy [8] and for pain control in a palliative setting [5].Whether the information reflects that SBRT was predominantly performed in the context of oligometastatic treatment concepts can only be hypothesized.
Fifty-nine percent of participants followed ICG for target volume delineation in primary and adjuvant SBRT.Few participants defined target volumes in accordance with proposed strategies of prospective studies.Some of the recommendations differ substantially, and as in adjuvant conventional RT, patterns-of-failure analyses and prospective data are desirable for valid, consistent target volume delineation strategies.A recent analysis strongly supports the systematic application of ICG in spine SBRT as it showed that deviation from ICG is significantly associated with inferior local tumor control [21].
This study has limitations due to its design as an anonymous online survey.There is no control on whether a participant has completed the survey more than once.Thus, it cannot be excluded with certainty that therapy strategies of individual participants are overrepresented in the results.The survey was conducted at the individual level, not at the department level.While the number of participants is representative at n = 80, it is unknown how many different facilities are represented by the survey.The survey depicts a comprehensive representation of the RT practice in spinal metastases of DEGRO members, however, it may not represent an overview of overall radiotherapy practice in Germany, as some centers may be overrepresented, or the geographical distribution of participants may be uneven.Nevertheless, the personal information requested in the survey showed that 21 chief physicians participated, meaning that the survey represents at least 21 different facilities, very likely more.

Conclusion
We provide the first representative depiction of the radiation oncology treatment patterns of care of spinal metastases both with regard to conventional palliative RT as well as SBRT among DEGRO members.
For conventional RT, answers regarding dose regimen showed congruence to some extent, with 30 Gy in 10 fractions being the dose regimen regularly used by a majority of participants both in primary and adjuvant RT.However, many different dose regimens are regularly used by DEGRO members, and target volume definition is heterogeneous.As spinal metastases are a common RT indication, further research such as analyses of failure patterns and especially prospective studies are needed to provide a solid data basis for detailed recommendations on conventional RT.
Primary SBRT is accessible at a majority of institutions (65%), however, adjuvant SBRT is not comprehensively offered.This might impact treatment regimen in specific cases.ICG for target volume delineation exist but are not always applied.Patterns-of-failure analyses and prospective data are desirable for valid, consistent target volume delineation strategies.Die folgenden Fragen beziehen sich sowohl auf die Bestrahlung in palliativer Intention als auch im Rahmen von Oligometastasierungskonzepten.

Title: Radiation concepts of spinal metastases
Part 1-Conventional radiotherapy of spinal metastases in primary palliative intention without previous surgery (no SBRT) Please answer the following questions exclusively related to primary irradiation of spinal metastases in palliative intention without previous surgery.Please only provide information on conventional radiotherapy (no SBRT).Please answer the following questions exclusively regarding primary stereotactic radiotherapy of spinal metastases.Questions regarding adjuvant SBRT will follow in a separate section.
The following questions refer to primary SBRT in palliative intention and the context of oligometastatic disease.

Fig. 1
Fig. 1 Pie charts of participantspecific results with a (upper left) illustrating proportions of level of seniority, b (upper right) showing type of institution and c (bottom) country of practice of the n = 80 participants of the survey

Fig. 2 Fig. 3
Fig.2Bar charts for dose regimens used in conventional RT in primary (a, top) and adjuvant (b, center) palliative intention as well as primary SBRT (c, bottom), whereby for the latter only fractionations mentioned at least twice are listed; x-axis: number of radiation oncologists indicating that they use the particular treatment regimen frequently; y-axis: all mentioned treatment regimens, from top to bottom with increasing EQD2

Table 1
Tabular overview of all mentioned publications regarding target volume definition in primary and post-operative, adjuvant SBRT of spinal metastases with their respective frequency of indication (n) by participants of this survey and the specified recommendations Gy in 3 fractions and 30 Gy in 5 fractions (n = 8, 17% each), 25 Gy in 5 fractions plus SIB with 40 Gy in 5 fractions and 30 Gy in 10 fractions plus SIB with 48.5 Gy in 10 fractions (n = 6, 13% each), 35 Gy in 5 fractions (n = 5, 11%), 24 Gy in 3 fractions (n = 4, 9%) as well as 30 Gy in 10 fractions plus SIB with 40 Gy in 10 fractions, Select one answer: Clinical radio-oncological followup is not provided.;Clinical radio-oncological followup is initiated only in case of new symptoms.;Clinical radio-oncological follow-up is provided regularly.;other [free text] 16.Which statement regarding imaging radio-oncological follow-up after irradiation of spinal metastases in palliative intention (primary and adjuvant) is applicable for your institution?Select one answer.Imaging refers to the treated bone metastasis/es: Dedicated imaging follow-up is not performed.;Dedicated imaging follow-up is initiated only in case of new symptoms.;Dedicated imaging follow-up is performed to assess local control after irradiation.;other [free text] Part 3-Primary stereotactic radiotherapy (SBRT) of spinal metastases without previous surgery 17.Is stereotactic radiotherapy (SBRT) for spinal metastases offered at your center?Select one answer: no; yes 18.Approximately how many patients with spinal metastases are treated with primary SBRT at your institution annually?Enter a number [free text] 19.Which dose regimen(s) do you most commonly use in primary SBRT for spinal metastases?Write a short text [free text] 20.What are the most critical factors driving your decision regarding prescription dose here?Select one or more answers: Size of the lesion; tumor histology; soft tissue component present; proximity to organs ot risk; risk of fracture of the vertebral body; therapy concept (palliation vs. oligometastatic concept); patient's prognosis; reimbursement; other [free text] 21.Based on which imaging modality is the treatment planning usually performed here?Select one answer: CT; CT and MRI; other [free text] 22. Do you regularly consider certain contouring recommendations for primary SBRT for spinal metastases?Select one or more answers: no; yes: International Spine Radiosurgery Consortium consensus guidelines for target volume definition in spinal stereotactic radiosurgery (Cox et al. [2012]); other [free text] Part 4-Adjuvant stereotactic radiotherapy (SBRT) of spinal metastases with previous surgery Unless otherwise indicated, please answer the following questions exclusively related to postoperative adjuvant stereotactic irradiation of vertebral metastases.The following questions refer to primary SBRT in palliative intention and the context of oligometastatic disease.23.Approximately how many patients with spinal metastases are treated with adjuvant SBRT at your institution annually?Enter a number [free text] 24.Which dose regimen(s) do you most commonly use in adjuvant SBRT for spinal metastases?Write a short text [free text] 25.What are the most critical factors driving your decision regarding prescription dose here?Select one or more answers: Size of the lesion; tumor histology; soft tissue component present; proximity to organs ot risk; risk of fracture of the vertebral body; therapy concept (palliation vs. oligometastatic concept); patient's prognosis; reimbursement; other [free text] 26.Based on which imaging modality is the treatment planning usually performed here?Select one answer: CT; CT and MRI; other [free text] 27.Do you regularly consider certain contouring recommendations for adjuvant SBRT for spinal metastases?Select one or more answers: no; yes: Consensus Contouring Guidelines for Postoperative Stereotactic Body Radiation Therapy for Metastatic Solid Tumor Malignancies to the Spine (Redmond et al. [2017]); other [free text] 28.Which radiation device is mainly used for SBRT of spinal metastases (primary and adjuvant) at your institution?Select one answer: Linear accelerator; Cyberknife Is a Cyberknife used exclusively at your institution for the irradiation of spinal metastases?Select one answer: yes; no Questions on the participant of the survey 29.What degree of experience in radiation oncology do you have?
Select one answer: Resident (1-3 years of working experience) in radiation oncology; Resident (4-5 years of working experience) in radiation oncology; specialist in radiation oncology; specialist in neurosurgery; se-K