Abstract
2′-O-Methylinosine (1) has been isolated for the first time and shown to be an intrinsic hypotensive principle. Its probable in vivo precursor, 2′-O-methyladenosine (3), showed stronger and even orally potent hypotensive activity. Resistance of the methyladenosine (3) against adenosine deaminase is thought to contribute to its long-lasting activity. The effect of both nucleosides (1 and 3) was not accompanied with any significant change in heart rate, which is often observed with adenosine.
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Received 2 October 1997; accepted 28 October 1997
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Yamada, T., Kageyama, K., Joh, Y. et al. Research Articles¶Naturally occurring 2′-O-methylpurine nucleosides with hypotensive properties. CMLS, Cell. Mol. Life Sci. 54, 125–128 (1998). https://doi.org/10.1007/s000180050131
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DOI: https://doi.org/10.1007/s000180050131