References
Jansen IE et al (2019) Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk. Nat Genet 51:404–413
Jaiswal S, Ebert BL (2019) Clonal hematopoiesis in human aging and disease. Science 366:eaan4673
Dai X, Guo X (2021) Decoding and rejuvenating human ageing genomes: lessons from mosaic chromosomal alterations. Ageing Res Rev 68:101342
Dumanski JP et al (2016) Mosaic loss of chromosome Y in blood is associated with Alzheimer disease. Am J Hum Genet 98:1208–1219
Thompson DJ et al (2019) Genetic predisposition to mosaic Y chromosome loss in blood. Nature 575:652–657
Guo X et al (2020) Mosaic loss of human Y chromosome: what, how and why. Hum Genet 139:421–446
Dumanski JP et al (2021) Immune cells lacking Y chromosome show dysregulation of autosomal gene expression. Cell Mol Life Sci 78:4019–4033
Mattisson J et al (2021) Leukocytes with chromosome Y loss have reduced abundance of the cell surface immunoprotein CD99. Sci Rep 11:15160
Gate D et al (2020) Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease. Nature 577:399–404
Itzhaki RF, Golde TE, Heneka MT, Readhead B (2020) Do infections have a role in the pathogenesis of Alzheimer disease? Nat Rev Neurol 16:193–197
Davis EJ et al (2020) A second X chromosome contributes to resilience in a mouse model of Alzheimer’s disease. Sci Transl Med 12:eaaz5677
Zekavat SM et al (2021) Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection. Nat Med 27:1012–1024
Guo X et al (2021) Loss of Y chromosome: an emerging next-generation biomarker for disease prediction and early detection? Mutat Res Rev Mutat Res 788:108389
Heyde A et al (2021) Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis. Cell 184:1348–1361
Funding
This work was funded by the National Natural Science Foundation of China (Project No. 31900410). This study was also supported by the Yunnan Fundamental Research Projects (Project Nos. 202001AU070055 and 202101AT070112) and the Outstanding Young Academics Award of Yunnan Normal University (2019).
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A commentary on “Immune cells lacking Y chromosome show dysregulation of autosomal gene expression” Cellular and Molecular Life Sciences, 78, 4019–4033 (2021).
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Guo, X. Loss of Y chromosome at the interface between aging and Alzheimer’s disease. Cell. Mol. Life Sci. 78, 7081–7084 (2021). https://doi.org/10.1007/s00018-021-03935-2
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DOI: https://doi.org/10.1007/s00018-021-03935-2