Skip to main content
Log in

Loss of Y chromosome at the interface between aging and Alzheimer’s disease

  • Commentary
  • Published:
Cellular and Molecular Life Sciences Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Jansen IE et al (2019) Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk. Nat Genet 51:404–413

    Article  CAS  Google Scholar 

  2. Jaiswal S, Ebert BL (2019) Clonal hematopoiesis in human aging and disease. Science 366:eaan4673

    Article  CAS  Google Scholar 

  3. Dai X, Guo X (2021) Decoding and rejuvenating human ageing genomes: lessons from mosaic chromosomal alterations. Ageing Res Rev 68:101342

    Article  CAS  Google Scholar 

  4. Dumanski JP et al (2016) Mosaic loss of chromosome Y in blood is associated with Alzheimer disease. Am J Hum Genet 98:1208–1219

    Article  CAS  Google Scholar 

  5. Thompson DJ et al (2019) Genetic predisposition to mosaic Y chromosome loss in blood. Nature 575:652–657

    Article  CAS  Google Scholar 

  6. Guo X et al (2020) Mosaic loss of human Y chromosome: what, how and why. Hum Genet 139:421–446

    Article  Google Scholar 

  7. Dumanski JP et al (2021) Immune cells lacking Y chromosome show dysregulation of autosomal gene expression. Cell Mol Life Sci 78:4019–4033

    Article  CAS  Google Scholar 

  8. Mattisson J et al (2021) Leukocytes with chromosome Y loss have reduced abundance of the cell surface immunoprotein CD99. Sci Rep 11:15160

    Article  CAS  Google Scholar 

  9. Gate D et al (2020) Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease. Nature 577:399–404

    Article  CAS  Google Scholar 

  10. Itzhaki RF, Golde TE, Heneka MT, Readhead B (2020) Do infections have a role in the pathogenesis of Alzheimer disease? Nat Rev Neurol 16:193–197

    Article  Google Scholar 

  11. Davis EJ et al (2020) A second X chromosome contributes to resilience in a mouse model of Alzheimer’s disease. Sci Transl Med 12:eaaz5677

    Article  CAS  Google Scholar 

  12. Zekavat SM et al (2021) Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection. Nat Med 27:1012–1024

    Article  CAS  Google Scholar 

  13. Guo X et al (2021) Loss of Y chromosome: an emerging next-generation biomarker for disease prediction and early detection? Mutat Res Rev Mutat Res 788:108389

    Article  CAS  Google Scholar 

  14. Heyde A et al (2021) Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis. Cell 184:1348–1361

    Article  CAS  Google Scholar 

Download references

Funding

This work was funded by the National Natural Science Foundation of China (Project No. 31900410). This study was also supported by the Yunnan Fundamental Research Projects (Project Nos. 202001AU070055 and 202101AT070112) and the Outstanding Young Academics Award of Yunnan Normal University (2019).

Author information

Authors and Affiliations

Authors

Contributions

XG contributed toward the design and structure of the manuscript.

Corresponding author

Correspondence to Xihan Guo.

Ethics declarations

Conflict of interest

The author declares that there is no conflict of interest.

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Availability of data and materials

Not applicable.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

A commentary on “Immune cells lacking Y chromosome show dysregulation of autosomal gene expression” Cellular and Molecular Life Sciences, 78, 4019–4033 (2021).

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Guo, X. Loss of Y chromosome at the interface between aging and Alzheimer’s disease. Cell. Mol. Life Sci. 78, 7081–7084 (2021). https://doi.org/10.1007/s00018-021-03935-2

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00018-021-03935-2

Navigation