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Cytoskeleton responses in wound repair

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Abstract

Wound repair on the cellular and multicellular levels is essential to the survival of complex organisms. In order to avoid further damage, prevent infection, and restore normal function, cells and tissues must rapidly seal and remodel the wounded area. The cytoskeleton is an important component of wound repair in that it is needed for actomyosin contraction, recruitment of repair machineries, and cell migration. Recent use of model systems and high-resolution microscopy has provided new insight into molecular aspects of the cytoskeletal response during wound repair. Here we discuss the role of the cytoskeleton in single-cell, embryonic, and adult repair, as well as the striking resemblance of these processes to normal developmental events and many diseases.

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Abbreviations

ERM:

Ezrin-radixin-moesin

SBMS:

Spectrin-based membrane skeleton

ECM:

Extracellular matrix

αSMA:

Alpha smooth muscle actin

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Acknowledgments

We thank Parkhurst lab members for their interest, advice, and comments on the manuscript. This work was supported by NIH Grant GM092731 to SMP.

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  1. Division of Basic Sciences, Fred Hutchinson Cancer Research Center, A1-162, 1100 Fairview Avenue North, Seattle, WA, 98109-1024, USA

    Maria Teresa Abreu-Blanco, James J. Watts, Jeffrey M. Verboon & Susan M. Parkhurst

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  1. Maria Teresa Abreu-Blanco
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Correspondence to Susan M. Parkhurst.

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Abreu-Blanco, M.T., Watts, J.J., Verboon, J.M. et al. Cytoskeleton responses in wound repair. Cell. Mol. Life Sci. 69, 2469–2483 (2012). https://doi.org/10.1007/s00018-012-0928-2

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