Abstract
2,4-Dibromo-5-fluorobenzonitrile has been synthesized for the first time (81.5% yield). It may be used in synthesizing 2,4-dibromo-5-fluorobenzoic acid, the intermediates of fluoroquinolones. The ammoxidation procedure for preparation of the nitrile has been described in detail.
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References
Sang J Chung, Dong H Kim. Systhesis of 3-fluoro-2-substituted amino-5, 12-dihydro-5-oxobenzoxazolo[3,2-α] quinoline-6-carboxylic acids emplouing the tadem double ring closure reaction of N-acetyl-N-(2-hydroxyphenyl) anthranilic acid as key step.Tetrahedron, 1995,51(46):12549–12562
Wang Shuliang, Dai Guiyuan Shi Daqing. Systhesis of halogenated toluenes and its liquid phase oxidation with Co (OAc)2−Mn(OAc)2−NaBr.Yingyong Huaxue, 1996,13(2):41–44 (in Chinese)
Han Qiyong, Tan Jieyi, Xu Chongwen,et al. New catalyst of manufacture chlorobenzonitrile. Chinese Patent, 89101565. 5, 1990-09-26
Zheng Qiong, Huang Chi, Xu Chongwen,et al. The research on a process for producing 2, 6-dichlorobenzonitrile by ammoxidation of 2, 6-dichlorotolene.J Wuhan Univ (Natural Science Edition) 1998,44(2): 167–170 (in Chinese)
Schach Thomas, Papenfuhs Theodor. Process for the preparation of 2,4-dichloro-5-fluorobenzonitrile from 5-bromo-2,4-dichlorofluorobenzene and cuprous cyanide. Eur Pat Appl EP500083, 1992-08-26
Shi Yujun, Zhang Huaixiang, Xu Yurong. Preparation of 2,4-dichloro-5-fluorobenzoic acid. Faming Zhuanli Shenging Gongkai Shuomingshu, CN1031074, 1989-02-15
Kumui Seisaku, Ohashi Masao, Yaginuma Yutaka,et al. Proces for the preparation of fluorobenzoic acids by trichloromethylation and hydrolysis of fluorobenzene derivatives. Eur Pat Appl EP0431373, 1991-01-12
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Zheng Qiong: born in 1945, Associate professor
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Qiong, Z., Chi, H., Chongwen, X. et al. Synthesis of 2,4-dibromo-5-fluorobenzonitrile. Wuhan Univ. J. Nat. Sci. 3, 509–510 (1998). https://doi.org/10.1007/BF02830062
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DOI: https://doi.org/10.1007/BF02830062