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Modifying effect of iron on lead-induced clastogenicity in mouse bone marrow cells

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Abstract

Essential trace elements such as iron (Fe) are known to interact with nonessential metals like lead (Pb), influencing its metabolism. Ferric chloride and lead nitrate were administered intraperitoneally to Swiss albino miceMus musculus singly and successively, with or without a time gap of 1 h, to study the degree of protection, if any, afforded by iron against the clastogenic effects induced by Pb in bone marrow cells. A decrease in the frequency of lead-induced chromosomal aberrations was observed when Fe was given together with or prior to Pb administration.

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Authors and Affiliations

  1. Centre of Advanced Study in Cell and Chromosome Research, Department of Botany, University of Calcutta, 35 Ballygunge Circular Road, 700 019, Calcutta

    Haimanti Dhir, Archana Sharma & Geeta Talukder

  2. Vivekananda Institute of Medical Sciences, 700 020, Calcutta, India

    Haimanti Dhir, Archana Sharma & Geeta Talukder

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  1. Haimanti Dhir
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  2. Archana Sharma
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  3. Geeta Talukder
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Dhir, H., Sharma, A. & Talukder, G. Modifying effect of iron on lead-induced clastogenicity in mouse bone marrow cells. Biol Trace Elem Res 34, 279–286 (1992). https://doi.org/10.1007/BF02783683

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  • DOI: https://doi.org/10.1007/BF02783683

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