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Combined cisplatin and radiation therapy in patients with invasive bladder cancer

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Abstract

Thirty-five patients with T2–T4 invasive bladder cancer were treated with combined cisplatin and radiation therapy. In 18 patients radical cystectomy was performed after the combined therapy. In the other 17 patients radical cystectomy could not be performed for various reasons. Pathological examination of the cystectomy specimens showed down-staging in 66.7% and no residual tumour in 33.3%. These results suggest a synergistic action of cisplatin and radiation. Side effects were not severe and were well tolerated. This combined therapy of cisplatin and radiation is very effective for invasive bladder cancer.

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References

  1. Whitmore, W. F. Jr., Marshall, V. F.: Radical total cystectomy for cancer of the bladder: 230 consecutive cases five years later.J. Urol., 87, 853 (1962).

    PubMed  Google Scholar 

  2. Richie, J. P., Skinner, D. G., Kaufman, J. J.: Radical cystectomy for cancer of the bladder: 16 years experience.J. Urol., 113, 186 (1975).

    PubMed  CAS  Google Scholar 

  3. Pearse H. D., Reed, R. R., Hodges, C. C.: Radical cystectomy for bladder cancer.J. Urol., 119, 216 (1978).

    PubMed  CAS  Google Scholar 

  4. Clark, P. B.: Radical cystectomy for cancer of the bladder.Br. J. Urol., 50, 492 (1978).

    Article  PubMed  CAS  Google Scholar 

  5. Miller, L. S.: Bladder cancer: superiority of preoperative irradiation and cystectomy in clinical stage B2 and C.Cancer, 39, 973 (1977).

    Article  PubMed  CAS  Google Scholar 

  6. Whitmore, W. F. Jr., Batata, M. A., Hilaris, B. S., Reddy, G. N., Unal, A., Ghoneim, M. A., Grabstald, H., Chu, F.: A comparative study of two preoperative radiation regimens with cystectomy for bladder cancer.Cancer, 40, 1077 (1977).

    Article  PubMed  Google Scholar 

  7. Skinner, D. G., Tift, J. P., Kaufman, J. J.: High dose, short course preoperative radiation therapy and immediate single stage radical cystectomy with pelvic node dissection in the management of bladder cancer.J. Urol., 127, 671 (1982).

    PubMed  CAS  Google Scholar 

  8. Goffinet, D. R., Schneider, M. J., Glatstein, E. J., Ludwig, H., Ray, G. R., Dunnick, N. R., Bagshow, M. A.: Bladder cancer: Results of radiation therapy in 384 patients.Radiology, 117, 149 (1975).

    PubMed  CAS  Google Scholar 

  9. Yu, W. S., Sagerman, R. M., Chung, C. T., Dalal, P. S., King, G. A.: Bladder carcinoma: Experience with radical and preoperative radiotherapy in 421 patients.Cancer, 56, 1293 (1985).

    Article  PubMed  CAS  Google Scholar 

  10. Soloway, M. S.: Cis-diaminedichloroplatinum(II) in advanced urothelial cancer.J. Urol., 120, 716 (1978).

    PubMed  CAS  Google Scholar 

  11. Yagoda, A., Watson, R. C., Kemmeny, N., Barzell, W. E., Grabstald, H., Whitmore, W. F., Jr.: Diaminedichloride platinum(II) and cyclophosphamide in the treatment of advanced urothelial cancer.Cancer, 41, 2121 (1978).

    Article  PubMed  CAS  Google Scholar 

  12. Wodinsky, I., Swiniarski, J., Kensler, C. J., Venditti, J. M.: Combination radiotherapy and chemotherapy for p388 lymphocytic leukemia in vivo.Cancer Chemopher. Rep., 4, 73 (1974).

    CAS  Google Scholar 

  13. Morris, C. R., Blackwell, L. H., Loveless, V. S.: Antileukemic properties of combinations of radiation and malanato (1,2-diaminocyclohexane) platinum(II) (NSC-224964).J. Med., 8, 254 (1977).

    Google Scholar 

  14. Soloway, M. S., Morris, C. R., Sudderth, B.: Radiation therapy and cis-diaminedichloroplatinum(II) in transplantable and primary murine bladder cancer.Int. J. Radiat. Oncol. Biol. Phys., 5, 1355 (1979).

    PubMed  CAS  Google Scholar 

  15. Kyriazis, A. P., Yagoda, A., Kereiakes, J. G., Kyriazis, A. A., Whitmore, W. F. Jr.: Experimental studies on the radiation-modifying effect of cis-diaminedichloroplatinum(II) (CDDP) in human bladder transitional carcinoma grown in nude mice.Cancer, 52, 452 (1983).

    Article  PubMed  CAS  Google Scholar 

  16. Soloway, M. S., Ikard, M., Scheinberg, M., Evans, J.: Concurrent radiation and cisplatin in the treatment of advanced bladder cancer: A preliminary report.J. Urol., 128, 1031 (1982).

    PubMed  CAS  Google Scholar 

  17. Herr, H. W., Yagoda, A., Batata, M., Sogani, P. C., Whitmore W. F. Jr.: Planned preoperative cisplatin and radiation therapy for locally advanced bladder cancer.Cancer, 52, 2205 (1983).

    Article  PubMed  CAS  Google Scholar 

  18. Jakse, G., Frommhold, H., ZurNedden, D.: Combined radiation and chemotherapy for locally advanced transitional cell carcinoma of the urinary bladder.Cancer, 55, 5659 (1985).

    Article  Google Scholar 

  19. Shipley, W. U., Prout, G. R. Jr., Einstein, A. B., Coombs, J., Wajsman, Z., Soloway, M. S., Englander, L., Barton, B. A., Hafermann, M. D.: Treatment of invasive bladder cancer by cisplatin and radiation in patients unsuited for surgery.JAMA, 258, 931 (1987).

    Article  PubMed  CAS  Google Scholar 

  20. Muggia, F. M., Glatstein, E.: Summary of investigations on platinum compounds and radiation interactions.Int. J. Radiat. Oncol. Biol. Phys., 5, 1407 (1979).

    PubMed  CAS  Google Scholar 

  21. Rosenberg, B.: Fundamental studies with cisplatin.Cancer, 55, 2303 (1985).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Urology, Hyogo College of Medicine, Hyogo, Japan

    Y. Mori, H. Ihara, H. Shima, K. Shimada, M. Arima & F. Ikoma

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  1. Y. Mori
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  2. H. Ihara
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  3. H. Shima
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  4. K. Shimada
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  5. M. Arima
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  6. F. Ikoma
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Mori, Y., Ihara, H., Shima, H. et al. Combined cisplatin and radiation therapy in patients with invasive bladder cancer. International Urology and Nephrology 22, 337–344 (1990). https://doi.org/10.1007/BF02549793

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  • DOI: https://doi.org/10.1007/BF02549793

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