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Metabolic Regulation of Tendon Inflammation and Healing Following Injury

  • Osteoarthritis (M Goldring and T Griffin, Section Editors)
  • Published:
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Abstract

Purpose of Review

This review seeks to provide an overview of the role of inflammation and metabolism in tendon cell function, tendinopathy, and tendon healing. We have summarized the state of knowledge in both tendon and enthesis.

Recent Findings

Recent advances in the field include a substantial improvement in our understanding of tendon cell biology, including the heterogeneity of the tenocyte environment during homeostasis, the diversity of the cellular milieu during in vivo tendon healing, and the effects of inflammation and altered metabolism on tendon cell function in vitro. In addition, the mechanisms by which altered systemic metabolism, such as diabetes, disrupts tendon homeostasis continue to be better understood.

Summary

A central conclusion of this review is the critical need to better define fundamental cellular and signaling mechanisms of inflammation and metabolism during tendon homeostasis, tendinopathy, and tendon healing in order to identify therapies to enhance or maintain tendon function.

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Author notes

  1. Jessica E. Ackerman and Katherine T. Best contributed equally to this work.

Authors and Affiliations

  1. Center for Musculoskeletal Research, Department of Orthopaedics, University of Rochester Medical Center, 601 Elmwood Ave, Box 665, Rochester, NY, 14642, USA

    Jessica E. Ackerman, Katherine T. Best, Samantha N. Muscat & Alayna E. Loiselle

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  1. Jessica E. Ackerman
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Jessica Ackerman, Katherine Best, Samantha Muscat, and Alayna Loiselle declare that they have no conflicts of interest.

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Ackerman, J.E., Best, K.T., Muscat, S.N. et al. Metabolic Regulation of Tendon Inflammation and Healing Following Injury. Curr Rheumatol Rep 23, 15 (2021). https://doi.org/10.1007/s11926-021-00981-4

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