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Anti-tumor effect and anti-inflammatory activity ofBoschniakia rossica

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Abstract

Objective: To investigate the anti-tumor effect and anti-inflammatory activity ofBoschniakia rossica (BR).Methods: The expression of tumor marker, GST-P, p53 and p21ras proteins in promotion stage of rat chemical hepatocarcinogenesis were examined by immunohistochemical technique ABC method. Anti-tumor effect of BR was investigated by inhibitory test on Sarcoma180. Anti-inflammatory activity of BR was tested by xylene-induced mouse ear swelling method.Results: BR-H2O extract (the H2O extract fractionated from BR-Methanol extract with CH2Cl2 and H2O) 500 mg/kg has inhibitory effect on the formation of diethylnitrosamine (DEN)-induced glutathione S-transferase placental form (GST-P) positive foci in rat liver with the expression of mutant p53 and p21ras proteins lower than those of non-treated hepatic preneoplastic lesions. BR extract showed inhibitory effect on Sarcoma180 and anti-inflammatory effect in mice by xylene-induced mouse ear swelling tests.conclusion: BR-H2O extract exerted inhibitory effect on DEN-induced preneoplastic hepatic foci in promotion stage of rat chemical hepatocarcinogenesis and might suppress the growth of solid Sarcoma180 in mice. Both CH2Cl2 and H2O extract from BR exerted anti-inflammatory effect in mice.

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Authors and Affiliations

  1. Department of Biochemistry, College of Medicine, Yanbian University, 121 Juzi Street, 133000, Yanji, Jilin Province

    Yin Zong-zhu M. D., Jin Hai-ling, Yin Xue-zhe, Quan Ji-shu, Jin Ming, Piao Chun-mei & Zhang Hong-ying

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  1. Yin Zong-zhu M. D.
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  2. Jin Hai-ling
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  3. Yin Xue-zhe
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  4. Quan Ji-shu
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  6. Piao Chun-mei
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  7. Zhang Hong-ying
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Correspondence to Yin Zong-zhu M. D..

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This work was supported by a grant from the National Natural Science Foundation of China (No. 39660021)

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Yin, Zz., Jin, Hl., Yin, Xz. et al. Anti-tumor effect and anti-inflammatory activity ofBoschniakia rossica . CJIM 7, 209–213 (2001). https://doi.org/10.1007/BF03178491

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  • DOI: https://doi.org/10.1007/BF03178491

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