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Initial clinical experiences with dopamine D2 receptor imaging by means of 2′-iodospiperone and single-photon emission computed tomography

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Abstract

Dopamine D2 receptor imaging was performed with123I labeled 2′-iodospiperone (2′-ISP) and single-photon emission computed tomography (SPECT) in 9 patients: 4 with idiopathic Parkinson’s disease, 2 with parkinsonism, 1 with Wilson’s disease and 2 with pituitary tumor, and the results were compared with the data for 9 normal subjects. Following an intravenous injection of123I-2′-ISP, early (within 30 min) and late (between 2 and 4 hr) SPECT images were obtained by means of a multi-detector SPECT scanner or a rotating gamma camera. In normal subjects, early SPECT images demonstrated uniform distribution of radioactivity in the cerebral gray matter and cerebellum reflecting regional cerebral blood flow, whereas late SPECT images showed high radioactivity only in the basal ganglia. All the patients with Parkinson’s disease also demonstrated symmetrical basal ganglia uptake in the late SPECT images, but it was diminished in parkinsonism and Wilson’s disease. One patient with a growth hormone-producing pituitary tumor had a positive uptake in the tumor. These preliminary clinical data demonstrated that 2′-ISP can be used for SPECT imaging of D2 dopamine receptors and may be of clinical value for the diagnosis and planning of the treatment of neurological diseases.

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Authors and Affiliations

  1. Biomedical Imaging Research Center, Fukui Medical School, 23 Shimoaizuki, Matsuoka-cho, Yoshida-gun, 910-11, Fukui, Japan

    Yoshiharu Yonekura & Tatsuro Tsuchida

  2. Faculty of Medicine, Kyoto University, Japan

    Yoshiharu Yonekura, Yasushi Iwasaki, Tatsuro Tsuchida, Hidenao Fukuyama, Akira Shimatsu, Yasuhiro Iida, Yasuhiro Magata, Junji Konishi & Hiroshi Shibasaki

  3. Faculty of Pharmaceutical Sciences, Kyoto University, Japan

    Hideo Saji & Akira Yokoyama

Authors
  1. Yoshiharu Yonekura
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  2. Hideo Saji
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  3. Yasushi Iwasaki
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  4. Tatsuro Tsuchida
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  5. Hidenao Fukuyama
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  6. Akira Shimatsu
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  7. Yasuhiro Iida
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  8. Yasuhiro Magata
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  9. Junji Konishi
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  10. Akira Yokoyama
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  11. Hiroshi Shibasaki
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Yonekura, Y., Saji, H., Iwasaki, Y. et al. Initial clinical experiences with dopamine D2 receptor imaging by means of 2′-iodospiperone and single-photon emission computed tomography. Ann Nucl Med 9, 131–136 (1995). https://doi.org/10.1007/BF03165039

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  • DOI: https://doi.org/10.1007/BF03165039

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