Effect of fluorine on the composition of bones: changes in the composition of bones of rats—Part I

Summary and Conclusions

o| li]1.|Studies have been carried out on the effect of fluorine on the composition of bones of rats. Though no consistent variations have been observed in the Ca:P ratio of fluorosis bones, these have been found to contain less nitrogen, and more calcium, phosphorus, carbonate and sodium than the corresponding bones of the controls. In rats receiving 2 mgm. of NaF per day for 14 weeks, the magnesium content of the bones has not been found to be altered, whereas, it has been observed to decrease in the case of rats receiving 4 mgm. of NaF per day for 10 weeks. 2. These results have been further confirmed in the rats, placed on diet deficient in (i) nitrogen, (ii) calcium and phosphorus, and (iii) nitrogen, calcium and phosphorus. 3. The changes in composition have been observed in all bones. Though in some cases, the changes in the composition of scapulas and epiphyses are the most marked, it cannot be definitely stated that, in fluorine poisoning, these bones are most affected. 4. Calcium and phosphorus of the diet have been found to exert a protective action against the effect of fluorine on the composition of bones. 5. The data presented in regard to the carbonate and magnesium content of the experimental bones are in direct contrast to the findings of the earlier workers.^{1, 4,8, 11}

The results are discussed in the second part of this piece of investigation.