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Serum ferritin and malignant tumours

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Abstract

Increased concentrations of serum ferritin are common in patients with malignant disease and appear to be a non-specific response. The present evidence does not suggest that serum ferritin assay is useful either for specific diagnosis or monitoring of malignant disease. A special role for acidic isoferritins in malignancy remains to be substantiated.

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References

  1. Harrison P M, Clegg A A, May K: Ferritin structure and function, in Jacobs A, Worwood M (eds).Iron in Biochemistry and medicine, vol. II, pp. 131–171. London, Academic Press (1980).

    Google Scholar 

  2. Bomford A B, Munro H N: Biosynthesis of ferritin and isoferritins, in Jacobs A, Worwood M (eds).Iron in Biochemistry and Medicine, vol. II, pp. 173–202. London, Academic Press (1980).

    Google Scholar 

  3. Worwood M: Ferritin in human tissues and serum.Clin Haemat 11, 275 (1982).

    PubMed  CAS  Google Scholar 

  4. Arosio P, Adelman T G, Drysdale J W: On ferritin heterogeneity. Further evidence for heteropolymens.J biol Chem 253, 4471 (1978).

    Google Scholar 

  5. Reissmann K R, Dietrich M R: On the presence of ferritin in the peripheral blood of patients with hepatocellular disease.J clin Invest 35, 588 (1956).

    Article  PubMed  CAS  Google Scholar 

  6. Wohlers S, Schonlau F: Uber das Vorkommen von Ferritin in Serum.Klin Woch 37, 445 (1959).

    Article  Google Scholar 

  7. Aungst C W: Ferritin in body fluids.J Lab Clin Med 71, 517 (1968).

    PubMed  CAS  Google Scholar 

  8. Addison G M, Beamish M R, Hales C N, Hodgkins M, Jacobs A, Llewellin P: An immunoradiometric assay for ferritin in the serum of normal subjects and patients with iron deficiency and iron overload.J Clin Path 25, 326 (1972).

    Article  PubMed  CAS  Google Scholar 

  9. Walters G O, Miller S M, Worwood M: Serum ferritin in concentration and iron stores in normal subjects.J Clin Path 26, 770 (1973).

    Article  PubMed  CAS  Google Scholar 

  10. Jacobs A, Worwood M: Ferritin in serum. Clinical and biochemical applications.New Engl J Med 292, 951 (1975).

    PubMed  CAS  Google Scholar 

  11. Worwood M: Serum ferritin, inCRC Critical Reviews in Clinical Laboratory Sciences, pp. 171–204.

  12. Worwood M: Serum ferritin, in Cook J D (ed):Methods in Haematology, vol. 1, pp. 59–89. London, Churchill-Livingstone.

  13. Bieber C P, Bieber M M: Detection of ferritin as a circulating tumour-associated antigen in Hodgkin's disease.Nat Cancer Inst Monogr 36 147 (1973).

    PubMed  CAS  Google Scholar 

  14. Sarcione D J, Stutzman L, Mittelman A: Ferritin synthesis by splenic tumour tissue of Hodgkin's disease.Experientia 31, 1334 (1975).

    Article  PubMed  CAS  Google Scholar 

  15. Sarcione E J, Smalley J R, Lema M J, Stutzman L: Increased ferritin synthesis and release by Hodgkin's disease peripheral blood lymphocytes.Int J Cancer 20, 339 (1977).

    Article  PubMed  CAS  Google Scholar 

  16. Worwood M, Summers M, Miller S, Jacobs A, Whittaker J A: Ferritin in blood cells from normal subjects and patients with leukaemia.Brit J Haemat 28, 27 (1974).

    Article  PubMed  CAS  Google Scholar 

  17. White G P, Worwood M, Parry D H, Jacobs A: Ferritin synthesis in normal and leukaemic lymphocytes.Nature 240, 584 (1974).

    Article  Google Scholar 

  18. Cragg S J, Jacobs A, Parry D H, Wagstaff M, Worwood M: Isoferritins in acute leukaemia.Brit J Cancer 35, 635 (1977).

    PubMed  CAS  Google Scholar 

  19. Wagstaff M, Worwood M, Jacobs A: Biochemical and immunological characterisation of ferritin from leukaemic cells.Brit J Haemat 45, 263 (1980).

    Article  PubMed  CAS  Google Scholar 

  20. Alpert E, Coston R L, Drysdale J W: Carcinofoetal human liver ferritins.Nature 242, 194 (1980).

    Article  Google Scholar 

  21. Massover W H: Mouse hepatoma and liver ferritins. Comparative structural studies.Biochim biophys Acta 579, 169 (1979).

    PubMed  CAS  Google Scholar 

  22. Marcus D M, Zinberg N: Isolation of ferritin from human mammary and pancreatic carcinomas by means of antibody immunoabsorbence.Arch Biochem Biophys 162, 493 (1974).

    Article  PubMed  CAS  Google Scholar 

  23. Alpert E, Quaroni A, Goldenberg D M Alterations in triptic peptide atoms of ferritins purified from human colon carcinoma.Biochim biophys Acta 581, 193 (1979).

    PubMed  CAS  Google Scholar 

  24. Hann H-W L, Levey H M, Evans A E: Serum ferritin as a guide to therapy in neuroblastoma.Cancer Res 40, 1411 (1980).

    PubMed  CAS  Google Scholar 

  25. Halliday J W, McKeering L V, Powell L W: Isoferritin composition of tissues and serum in human cancers.Cancer Res 36, 4486 (1976).

    PubMed  CAS  Google Scholar 

  26. Miles L E M, Lipschitz D A, Bieber C P, Cook J D: Measurement of serum ferritin by a 2-site immunoradiometric assay.Analyt Biochem 61, 209 (1974).

    Article  PubMed  CAS  Google Scholar 

  27. Hazard J T, Drysdale J W: Ferritinaemia in cancer.Nature 265, 755 (1977).

    Article  PubMed  CAS  Google Scholar 

  28. Jones B M, Worwood M: An immunoradiometric assay for the acidic ferritin of human heart: application to human tissues, cells and serum.Clin Chim Acta 85, 81 (1978).

    Article  PubMed  CAS  Google Scholar 

  29. Jones B M, Worwood M, Jacobs A: Serum ferritin in patients with cancer: determination with antibodies to HeLa cells and spleen ferritin.Clin Chim Acta 166, 203 (1980).

    Article  Google Scholar 

  30. Niitsu Y, Goto Y, Kohgo Y, Adachi C, Onodera Y, Urushizaki I: Evaluation of heart isoferritin assay for diagnosis of cancer, in Albertini A (ed.):Radioimmunoassay of Hormones Proteins and Enzymes, pp. 256–266. Amsterdam, Excerpta Medica.

  31. Mori W, Asakawa H, Taguchi T, Sakai R: Human isoferritin and malignant neoplasms.Acta Haemat Jap 41, 1309 (1978).

    PubMed  CAS  Google Scholar 

  32. Mack U, Cooksley W G E, Ferris R A, Powell L W, Halliday J W: Regulation of plasma ferritin in isolated perfused rat liver.Brit J Haemat 47, 403 (1981).

    Article  PubMed  CAS  Google Scholar 

  33. Prieto J, Barry M, Sherlock S: Serum ferritin in patients with iron overload and acute and chronic liver diseases.Gastroenterology 68, 525 (1975).

    PubMed  CAS  Google Scholar 

  34. Konijn A M, Hershko C: Ferritin synthesis in inflammation. 1. Pathogenesis of impaired iron release.Brit J Haemat 37, 7 (1977).

    PubMed  CAS  Google Scholar 

  35. Gregg P J, Eastham E J, Bell J I, Walder D N: Serum ferritin and dysbaric osteonecrosis.Undersea Biomed Res 4, 75 (1977).

    PubMed  CAS  Google Scholar 

  36. Worwood M, Cragg S J, Wagstaff M, Jacobs A: Binding of human serum ferritin to concanavalinA. Clin Sci 56, 83 (1979).

    CAS  Google Scholar 

  37. Worwood M, Cragg S J, Williams A M, Wagstaff M, Jacobs A: The clearance of131 I-human plasma ferritin in man.Blood 60, 827 (1982).

    PubMed  CAS  Google Scholar 

  38. Cragg S J, Covell A M, Burch A, Owen G M, Jacobs A, Worwood M: Turnover of131 I-human spleen ferritin in plasma.Brit J Haemat (in press).

  39. Mack U, Powell L W, Halliday J W: A receptor for ferritin on hepatocytes.J biol Chem 258, 4672 (1983).

    PubMed  CAS  Google Scholar 

  40. Covell A M: Turnover of ferritin in plasma. PhD thesis. University of Wales (1983).

  41. Jones P A E, Miller S M, Worwood M, Jacobs A: Ferritinaemia in leukaemia and Hodgkin's disease.Brit J Cancer 27, 212 (1973).

    PubMed  CAS  Google Scholar 

  42. Parry D H, Worwood M, Jacobs A: Serum ferritin in acute leukaemia at presentation and during remissions.Brit Med J 1, 245 (1975).

    PubMed  CAS  Google Scholar 

  43. Matzner Y, Konijn A M, Hershko C: Serum ferritin in haematological malignancies.Am J Hemat 9, 13 (1980).

    Article  PubMed  CAS  Google Scholar 

  44. Siimes M A, Wang W C, Dalman P R: Elevated serum ferritin in children with malignancies.Scand J Haemat 19, 153 (1977).

    PubMed  CAS  Google Scholar 

  45. Parry D H, Ricketts, Jacobs A: Serum ferritin during unmaintained remission in acute lymphoblastic leukaemia.Brit Med J 2, 1341 (1978).

    PubMed  CAS  Google Scholar 

  46. Koller M-E, Romslo P H, Finne P H, Hanneberg B: Serial determinations of serum ferritin in children with acute lymphoblastic leukaemia.Acta Paediat Scand 68, 93 (1979).

    Article  PubMed  CAS  Google Scholar 

  47. Lang J M, Aber M, Methlin G, Oberling F: Serum ferritin during the course of chronic myeloid leukaemia. Increase of serum ferritin as a marker of dyserythropoiesis.Acta Haemat 67, 145 (1982).

    Article  PubMed  CAS  Google Scholar 

  48. May A, De Souza P, Barnes K, Kaaba S, Jacobs A: Erythroblast iron metabolism in sideroblastic marrows.Brit J Haem 52, 611 (1982).

    Article  CAS  Google Scholar 

  49. Jacobs A, Slater A, Whittaker J A, Cannelos G, Wiernik P H: Serum ferritin concentration in untreated hodgkin's disease.Brit J Cancer 34, 162 (1976).

    PubMed  CAS  Google Scholar 

  50. Marcus D M, Zinberg N: Measurement of serum ferritin by radioimmunoassay: results in normal individuals and patients with breast cancer.J Nat Cancer Inst 55, 791 (1975).

    PubMed  CAS  Google Scholar 

  51. Jacobs A, Jones B, Ricketts C, Bulbrook R D, Wang D Y: Serum ferritin concentration in early breast cancer.Brit J Cancer 34, 286 (1976).

    PubMed  CAS  Google Scholar 

  52. Coombes R C, Powles T J, Gazet J C, Ford H G, Slone J P, Laurence D J R, Neville A M: Biochemical markers in human breast cancer.Lancet 1, 132 (1977).

    Article  PubMed  CAS  Google Scholar 

  53. Coombes R C, Powles T J, Gazet J C, Ford H T, McKinna A, Gehrke C W, Keyser J W, Mitchell P E G, Patel S, Stimson, W H, Worwood M, Jones M, Neville A M: Screening for metastases in breast cancer: an assessment of biological and physical methods.Cancer 48, 310 (1981).

    Article  PubMed  CAS  Google Scholar 

  54. Bezwoda W, Derman D, Bothwell T, MacPhail P, Levin J, DeMoor N: Significance of serum concentrations of carcino embryonic antigen, ferritin and calcitonen in breast cancer.Cancer 48, 1623 (1981).

    Article  PubMed  CAS  Google Scholar 

  55. Nitti D, Fabris C, Del Favero G, Farini R, Crassi F, Farini A, Baccaglini U, Pedrazzoli S, Piccoli A, Lise M, Naccarato R: Serum ferritin in pancreatic disease. An accurate test of malignancy?.Digestion 25, 258 (1982).

    PubMed  CAS  Google Scholar 

  56. Ito H, Takagi Y, Ando Y, Kubo A, Hashimoto S, Tsutsui F, Kurihara S: Serum ferritin levels in patients with cervical cancer.Obst Gyn 55, 358 (1980).

    CAS  Google Scholar 

  57. Grail A, Bates G, Milford Ward A, Jones W G, Hancock B W: Serum ferritin as a third marker in germ cell tumours.Eur J Cancer Clin Oncol 18, 261 (1982).

    Article  PubMed  CAS  Google Scholar 

  58. Hann H-W L, Evans A E, Cowin I J, Leitmeyer J E: Biological differences between neuroblastoma stages IV-S and IV: measurement of serum ferritin and E rosette inhibition in 30 children.New Engl J Med 305, 425 (1981).

    PubMed  CAS  Google Scholar 

  59. Kew M C, Torrance J D, Derman D, Simon M, Macnab G M, Charlton R W, Bothwell T H: Serum and tumour ferritins in primary liver cancer.Gut 19, 294 (1978).

    Article  PubMed  CAS  Google Scholar 

  60. Chapman R W, Bassendine M S, Laulicht M, Gorman A, Thomas H C, Sherlock S, Hoffbrand A V: Serum ferritin and binding of serum ferritin to concanavalin A as a tumour marker in patients with primary liver cell cancer and chronic liver disease.Digest Dis Sci 27, 111 (1982).

    Article  PubMed  CAS  Google Scholar 

  61. Melia, W M, Bullock S, Johnson P J, Williams R: Serum ferritin in hepatocellular carcinoma: a comparison with alpha foetoprotein.Cancer 51, 2112 (1982).

    Article  Google Scholar 

  62. Arosio P, Iacobello C, Montesoro E, Albertini A: Serum ferritin evaluation with radioimmunoassays specific for HeLa and liver ferritin types.Immun Lett 3, 309 (1981).

    Article  CAS  Google Scholar 

  63. Cazzola M, Arosio P, Gobbi P G, Barosi G, Bergamaschi G, Dezza L, Iacobello C, Ascari E: Basic and acidic isoferritins in the serum of patients with Hodgkin's disease.Eur J Cancer Clin Oncol 19, 339 (1983).

    Article  PubMed  CAS  Google Scholar 

  64. International Committee for Standardisation in Haematology. Preparation, characterisation and storage of human ferritin for use as a standard for the assay of serum ferritin (in preparation).

  65. Oertel J: An ion-exchange chromatography of serum ferritin in patients with malignant diseases.Tumour Diagnost 2, 99 (1981).

    Google Scholar 

  66. Worwood M, Covell A M, Cragg S J, Jacobs A: Turnover of ferritin in plasma.Proc Sixth Int Conf Proteins of Iron Storage and Transport Sapporo (1983).

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  1. Department of Haematology, Welsh National School of Medicine, Cardiff, U.K.

    Allan Jacobs

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Jacobs, A. Serum ferritin and malignant tumours. Med. Oncol. & Tumor Pharmacother. 1, 149–156 (1984). https://doi.org/10.1007/BF02934136

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