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Protein p53 expression, cell proliferation and steroid hormone receptors in ductal carcinoma in situ of the breast

Protein-p53-Expression, Zellproliferation und Steroidhormonrezeptorexpression in intraduktalem Mammakarzinom

  • Themenschwerpunkt: Das Duktale In-Situ-Karzinom Der Mamma — Diagnostisches Und Therapeutisches Vorgehen
  • Published:
Acta Chirurgica Austriaca Aims and scope Submit manuscript

Summary

Background: Until recently intraductal carcinomas (DCIS) were thought to be a single entity of disease. In order to examine this theory we examined DCIS with respect to several morphological parameters.

Methods: 88 DCIS were investigated by steroid hormone receptors, p53 and cellular proliferation determined by MIB1. DCIS were classified according to the new suggestion by EORTC. This classification is based mainly on nuclear pleomorphism and architectural pattern.

Results: All prognostic factors showed direct or inverse correlation, respectively, with subclassification of DCIS. There existed a significant correlation between steroid hormone receptor positivity and low proliferative activity in low grade DCIS subgroup compared to high grade DCIS. In contrast p53 expression was high in high grade DCIS and showed only little positivity in low grade DCIS.

Conclusions: It is concluded that DCIS classification based on nuclear pleomorphism may become an important prognosticator in the future.

Zusammenfassung

Grundlagen: Bis vor kurzer Zeit wurde das intraduktale Mammakarzinom (DCIS) als eine Krankheitsentität aufgefaßt. Um diese Theorie zu überprüfen, untersuchten wir mehrere morphologische Parameter bei DCIS.

Methodik: 88 DCIS wurden hinsichtlich des Steroidhormonrezeptorstatus, p53 und der zellulären Proliferation mittels MIB1 untersucht. Die DCIS wurden entsprechend dem neuen Klassifikationsvorschlag der EORTC klassifiziert. Diese Klassifikation beruht vor allem auf nukleären Merkmalen und auf architektonischen Faktoren.

Ergebnisse: Alle untersuchten prognostischen Faktoren zeigten eine direkte oder eine inverse Korrelation mit den Subgruppen des DCIS. Es fand sich eine statistisch signifikante Korrelation zwischen positiven Steroidhormonrezeptoren, niedriger proliferativer Aktivität und niedrigem Malignitätsgrad der DCIS im Vergleich zu DCIS hohen Malignitätsgrades. Im Gegensatz dazu war p53 deutlich häufiger bei DCIS hohen Malignitätsgrades exprimiert und zeigte bei DCIS niedriger Malignität nur selten eine Expression.

Schlußfolgerungen: Aus diesen Ergebnissen wird geschlossen, daß in Zukunft Klassifikationen für DCIS prognostische Bedeutung erlangen könnten, die nukleäre Polymorphie als wesentliches Merkmal berücksichtigen.

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Authors and Affiliations

  1. Pathological-Bacteriological Institute, Donauspital, SMZ Ost, Langobardenstraße 122, A-1220, Vienna

    Angelika Reiner M.D. & Renate Neumayer

  2. Department of Pathology, Division of Clinical Pathology, Austria

    Margaretha Rudas

  3. Department of Surgery, Division of General Surgery, University of Vienna, Austria

    M. F. X. Gnant, Martina Mittlböck & R. Jakesz

Authors
  1. Angelika Reiner M.D.
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  2. Margaretha Rudas
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  3. Renate Neumayer
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  4. M. F. X. Gnant
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  5. Martina Mittlböck
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  6. R. Jakesz
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Reiner, A., Rudas, M., Neumayer, R. et al. Protein p53 expression, cell proliferation and steroid hormone receptors in ductal carcinoma in situ of the breast. Acta Chir Austriaca 29, 123–125 (1997). https://doi.org/10.1007/BF02619764

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  • DOI: https://doi.org/10.1007/BF02619764

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