Skip to main content
SpringerLink
Log in

Impaired urine concentrating ability in Itai-itai (ouch-ouch) disease

  • Published:
International Urology and Nephrology Aims and scope Submit manuscript

Abstract

A case of Itai-itai (ouch-ouch) disease with reduced urinary kallikrein excretion and slightly enhanced renin-angiotensin-aldosterone system is described. Although it is well known that cadmium toxicity frequently affects the renal tubular lesions, this report is the first to demonstrate the impaired urine concentrating ability in this disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Aoshima, K., Teranishi, H., Kasuya, M., Hagino, N.: Pathogenesis and pathophysiology of Itai-itai disease: a report of two cases and its clinical study (in Japanese).Jpn. J. Intern. Med., 73, 838 (1984).

    CAS  Google Scholar 

  2. Aqus, Z. S., Pusbtt, J. B., Senesky, D., Goldberg, M.: Mode of action of parathyroid hormone and cyclic adenosine 3′–5′-monophosphate on renal tubular phosphate reabsorption in dog.J. Clin. Invest., 50, 617 (1971).

    Article  Google Scholar 

  3. Bastle, C. P.: Assessment of renal function: characteristics of the functional and organic forms of acute renal failure, In: Seldin, D. W., Giebisch, G. (eds): The Kidney, Physiology and Pathology. Raven Press, New York 1985, Vol. II, pp. 1819–1836.

    Google Scholar 

  4. Chan, M. J. C., Gill, J. R. Jr., Bartter, F. C.: Lack of evidence for a role for prostaglandins in the mediation of impaired urinary concentrating ability in Bartter’s syndrome.Nephron, 35, 116 (1983).

    PubMed  CAS  Google Scholar 

  5. Cherian, M. G., Goyer, R. A., Delaquerriere-Richardson, I.: Cadmium-metallothinein-induced nephropathy.Toxicol. Appl. Pharmacol., 38, 399 (1976).

    Article  PubMed  CAS  Google Scholar 

  6. Chowdhury, P., Louria, D. B.: Influence of cadmium and other metals on human α1-antitrypsin: an in vitro study.Science, 191, 480 (1976).

    Article  PubMed  CAS  Google Scholar 

  7. Conte, G., Canton, A. D., Balletta, M., Meccariello, S., Sabbatini, M., Andreucci, V. E.: Mechanism of impaired urinary concentrating ability in normokalemic primary aldosteronism.Clin. Nephrol., 22, 90 (1984).

    Google Scholar 

  8. Edwards, B. R., Celai, M., Valtin, H.: Concentration of urine in the absence of ADH with minimal or no decrease in GFR.Am. J. Physiol., 239, F84 (1980).

    PubMed  CAS  Google Scholar 

  9. Edwards, C. R. W., Kitau, M. J., Chard, T., Besser, G. M.: Vasopressin analogue DDAVP diabetes insipidus: clinical and laboratory studies.Br. Med. J., 18, 375 (1973).

    Article  Google Scholar 

  10. Ellis, K. J., Morgan, W. D., Zanzi, I., Yasumura, S., Cohn, S. H.: Critical concentration of cadmium in human renal cortex: dose-effect studies in cadmium smelter workers.J. Toxicol. Envir. Hlth, 7, 691 (1981).

    Article  CAS  Google Scholar 

  11. Kitagawa, M., Miwa, A., Murai, Y.: Autopsy of 27 patients with Itai-itai disease in Toyama prefecture (in Japanese).Kankyo Hoken Report 49, 140 (1983).

    Google Scholar 

  12. Nakada, T.: Uninary kallikrein excretion in patients with primary aldosteronism: differentiation of adrenal adenoma from idiopathic adrenal hyperplasia.Urol. Int., 39, 4 (1984).

    Article  Google Scholar 

  13. Neathery, M. W., Lassiter, J. W., Miller, W. J.: Cadmium-109 and methyl mercury-203 metabolism, tissue distribution and secretion into milk of cows.J. Dairy Sci., 57, 1177 (1974).

    Article  PubMed  CAS  Google Scholar 

  14. Nishiizumi, M.: Electron microscopic study of cadmium nephrotoxicity in the rat.Arch. Environ. Health, 24, 215 (1972).

    Google Scholar 

  15. Nogawa, K., Ishizaki, A., Kobayashi, E.: A comparison between health effects of cadmium concentration in urine among inhabitants of the Itai-itai disease endemic district.Environ. Res., 18, 397 (1979).

    Article  PubMed  CAS  Google Scholar 

  16. Piscator, M.: Serum β2-microglobulin in cadmium exposed workers.Pathol. Biol., 26, 321 (1978).

    PubMed  CAS  Google Scholar 

  17. Thurau, K., Boylan, J. W.: Acute renal success: the unexpected logic of oliguria in acute renal failure.Am. J. Med., 61, 308 (1976).

    Article  PubMed  CAS  Google Scholar 

  18. Tohyama, C., Shalkh, Z. A., Ellis, K. J., Corn, S. H.: Metallothionein excretion in urine upon cadmium exposure: its relationship with liver and kidney cadmium.Toxicology, 22, 181 (1981).

    Article  PubMed  CAS  Google Scholar 

  19. Tsuchiya, K., Iwo, S., Sugita, H.: Increased urinary β2-microglobulin in cadmium exposure: dose-effect relationship and biological significance of β2-microblobulin.Envir. Hlth Perspect., 28, 147 (1979).

    CAS  Google Scholar 

  20. Van Bruwaene, R., Kirchmann, R., Impens, R.: Cadmium contamination in agriculture and zootechnology.Experientia, 40, 43 (1984).

    Article  PubMed  Google Scholar 

  21. Weinman, E. J.: Renal handling of uric acid, In: Massry, S. G., Glassock, R. J. (eds): Textbook of Nephrology. Williams & Wilkins, Baltimore-London 1983, Vol. I, pp. 1.54–1.56.

    Google Scholar 

  22. Weinman, E. J., Knight, T. F.: Renal tubular transport of urate.Miner. Electrolyte Metab. 1, 121 (1978).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Urology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan

    T. Nakada, H. Furuta, H. Koike, T. Katayama & H. Teranishi

Authors
  1. T. Nakada
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. Furuta
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. Koike
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T. Katayama
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. H. Teranishi
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nakada, T., Furuta, H., Koike, H. et al. Impaired urine concentrating ability in Itai-itai (ouch-ouch) disease. International Urology and Nephrology 21, 201–209 (1989). https://doi.org/10.1007/BF02550809

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02550809

Keywords

Search

Navigation