Summary
Amantadine is generally used in the prophylaxis of infection with influenza A, in the treatment of Parkinson's disease and in the treatment of neuroleptic side effects. In this study acute effects of amantadine infusions on event-related potentials (ERP) were studied in 20 mildly demented patients diagnosed according to DSM-III-R criteria. Each patient was treated, in randomized order, with 0.2 g amantadinesulfate in 500 ml NaCl and 500 ml NaCl placebo, i.v. over one hour with an interval of two weeks inbetween. ERPs were investigated in an auditory odd-ball paradigm before as well as 5 hours after the infusion. In addition to 17 EEG records, vertical and horizontal EOGs were recorded. After EOG-minimization and visual artifact rejection the peak latencies of the spatial average were determined by an automatic procedure. There was no effect of amantadine on ERP latencies. N 1 of the non-target showed a trend towards amplitude augmentation, P2 amplitude was reduced. As compared to placebo, P300 amplitude of targets was significantly augmented by 3.1 μV (30% of pre-treatment value), confirming the hypothesis that amantadine may influence the P300 amplitude in the sense of an improved availability of cognitive processing resources.
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References
Abt K (1989) Descriptive data analysis (DDA) in quantitative EEG studies. In: Samson-Dollfus D, Guieu JD, Gotman J, Etevenon P (eds) Statistics and topography in quantitative EEG. Elsevier, Amsterdam, pp 150–160
Agren H, Osterberg B, Niklasson F, Franzen O (1983) Depression and somatosensory evoked potentials. I. Correlations between SEP and monoamine and purine metabolites in CSF. Biol Psychiatry 18: 635–649
Amabile G, Fattapposta F, Pierelli F (1990) Evoked potentials in Parkinson's disease: sensory and cognitive aspects. A review. J Psychophysiol 4: 115–122
American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders, 3rd ed-revised (DSM-III-R). American Psychiatric Association, Washington DC
Anderer P, Saletu B, Kinsperger K, Semlitsch HV (1987) Topographic brain mapping of EEG in neuropsychopharmacology. Part I. Methodological aspects. Methods Find Exp Clin Pharmacol 9: 371–384
Anderer P, Semlitsch HV, Saletu B, Binder GA, Decker KA (1991) A demonstration of the effect of reference on P300-topograpy. J Psychophysiol 5: 97–98 (Abstract)
Blackman JD, Towle VL, Lewis GF, Spire J, Polonsky KS (1990) Hypoglycemic thresholds for cognitive dysfunction in humans. Diabetes 39: 828–835
Blackwood DHR, Christie JE (1986) The effects of physostigmine on memory and auditory P300 in Alzheimer-type dementia. Biol Psychiatry 21: 557–560
Dierks T, Maurer K, Ihl R (1991) Influence of tenilsetam on AEP-P300 in Alzheimer's disease. J Neural Transm (P-D Sect) 1: 49–49
Erkulwater S, Pillai R (1989) Amantadine and the end-stage dementia of Alzheimer's type. South Med J 82: 550–554
Estrin WJ, Bowler RM, Lash A, Becker CE (1990) Neurotoxicological evaluation of hospital sterilizer workers exposed to ethylene oxide. J Toxicol Clin Toxicol 28: 1–20
Fink M (1990) How does convulsive therapy work. Neuropsychopharmacology 3: 73–82
Goodin DS (1990) Clinical utility of long latency “cognitive” event-related potentials (P3): the pros. Electroencephalogr Clin Neurophysiol 76: 2–5 (discuss)
Goodin DS, Aminoff MJ, Chernoff DN, Hollander H (1990) Long latency event-related potentials in patients infected with human immunodeficiency virus. Ann Neurol 27: 414–419
Goodin DS, Squires KC, Henderson BH, Starr A (1978a) Age-related variations in evoked potentials to auditory stimuli in normal human subjects. Electroencephalogr Clin Neurophysiol 45: 447–458
Goodin DS, Squires KC, Starr A (1978b) Long-latency event-related components of the auditory evoked potential in dementia. Brain 101: 635–648
Gordon E, Kraiuhin C, Harris A, et al (1986a) The differential diagnosis of dementia using P300 latency. Biol Psychiatry 21: 1123–1132
Gordon E, Kraiuhin C, Stanfield P, Meares R, Howson A (1986b) The prediction of normal P3 latency and the diagnosis of dementia. Neuropsychologia 24: 823–830
Gualtieri B (1988) Pharmacotherapy and the neurobehavioural sequelae of traumatic brain injury. Brain Inj 2: 101–129
Gualtieri T, Chandler M, Coons TB, Brown LT (1989) Amantadine: a new clinical profile for traumatic brain injury. Clin Neuropharmacol 12: 258–270
Hader W, Duquette P, Auty A, Hashimoto S, Noseworthy J, Sawa G, Brunet D, Nelson R, Gray T, Klein G, Francis G, Lapierre Y, Weinshenker B, Barkas W, Philips S, Girard M, Murray TJ (1987) A randomized controlled trial of amantadine in fatigue associated with multiple sclerosis. Can J Neurol Sci 14: 273–278
Herrmann WM, Abt K, Coppola R, Etevenon ET, Gerber G, Fink M, Gevins AS, Hinrichs H, Itil TM, John ER, Kubicki S, Künkel H, Kugler J, Lehmann D, Petsche H, Rappelsberger P, Röhmel J, Saito M, Saletu B, Scheuler W (1989) International Pharmaco-EEG Group (IPEG). Recommendations for EEG and Evoked Potential Mapping. Neuropsychology 22: 170–176
Itil TM (1974) Quantitative pharmaco-electroencephalography. Use of computerized cerebral biopotentials in psychotropic drug research. In: Itil TM (ed) Psychotropic drugs and the human EEG: modern problems of pharmacopsychiatry. Karger, Basel, pp 43–75
Itil TM, Saletu B, Coffin C, Klingenberg H (1972) Quantitative EEG changes during thiothixene treatment of chronic schizophrenics. Clin EEG 3: 109–117
Ito J, Yamao S, Fukuda H, Mimori Y, Nakamura S (1990) The P300 event-related potentials in dementia of the Alzheimer type. Correlations between P300 and monoamine metabolites. Electroencephalogr Clin Neurophysiol 77: 174–178
Janke W, Debus G (1978) Die Eigenschaftswörterliste EWL. Hogrefe, Göttingen Toronto Zürich
Jellinger K, Flament H, Reiderer P (1989) Levodopa in the treatment of (pre) senile dementia. Mech Ageing Dev 14: 253–264
Johnson R Jr (1986) A triachic model of P300 amplitude. Psychophysiology 23: 367–384
Kraiuhin C, Gordon E, Stanfield P, et al (1987) P300 and the effects of aging: relevance to the diagnosis of dementia. Exp Aging Res 12: 187–192
Kugler J (1975) Die Beeinflußung von Vigilanz und Bewußtsein durch Amantadinsulfat. Akt Neurol: 43–51
Kuskowski MA, Morley G, Malone SM, Dysken MW, Okaya A (1990) Hydergine treatment and psychophysiological measures in primary degenerative dementia. J Geriatr Psychiatry Neurol 3: 41–47
Magliero A, Bashore TR, Coles MGH, Donchin E (1984) On the dependence of P300 latency on stimulus evaluation processes. Psychophysiology 21: 171–186
Maurer K, Ihl R, Dierks T (1988) Topographie der P300 in der Psychiatrie. II. Kognitive P300-Felder bei Demenz (Topography of P300 in psychiatry. II. Cognitive P300 fields in dementia). EEG EMG 19: 26–29
Murray TJ (1985) Amantadine therapy for fatigue in multiple sclerosis. Can J Neurol Sci 12: 251–254
Münte TF, Heinze HJ, Scholz M, Künkel H (1988) Effects of a cholinergic nootropic (WEB 1881 FU) on event-related potentials recorded in incidental and intentional memory tasks. Neuropsychobiology 19: 158–168
Münte TF, Heinze H, Scholz MB, Bartusch SM, Dietrich DE (1989) Event-related potentials and visual spatial attention: influence of a cholinergic drug. Neuropsychobiology 21: 94–99
Neshige R, Barrett G, Shibasaki H (1988) Auditory long latency event-related potentials in Alzheimer's disease and multi-infarct dementia. J Neurol Neurosurg Psychiatry 51: 1120–1125
Newton MR, Barrett G, Callanan MM, Towell AD (1989) Cognitive event-related potentials in multiple sclerosis. Brain 112: 1637–1660
Nicholson CD (1990) Pharmacology of nootropics and metabolically active compounds in relation to their use in dementia. Psychopharmacology 101: 147–159
Nobilio D, Faricelli A, Colangelo U, Delre ML, Bazzano S, Onofri M, Gambi D (1990) The effect of levo-acetyl-carnitine on P300 potential. Curr Ther Res Clin Exp 47: 267–277
Onofrj M, Ghilardi MF, Faricelli A, Bodis-Wollner I, Calvani M (1987) Effect of levoacetylcarnitine on P300-like potentials of the normal monkey. Drugs Exp Clin Res 13: 407–415
Pepeu G, Spignoli G (1990) Neurochemical actions of “nootropic drugs”. Adv Neurol 51: 247–252
Peterson PL, Saad J, Nigro MA (1988) The treatment of Friedreich's taxia with amantadine hydrochloride. Neurology 38: 1478–1480
Pfefferbaum A, Ford JM, Wenegrat BG, Roth WT, Kopell BS (1984) Clinical application of the P3 component of event-related potentials. I. Normal aging. Electroencephalogr Clin Neurophysiol 59: 85–103
Pfefferbaum A, Ford JM, Kraemer HC (1990) Clinical utility of long latency “cognitive” event-related potentials (P3): the cons. Electroencephalogr Clin Neurophysiol 76: 6–12; discus
Pierrot-Deseilligny C, Turell E, Penet C, Lebrigand D, Pillon B, Chain F, Agid Y (1989) Increased wave P300 latency in progressive supranuclear palsy. J Neurol Neurosurg Psychiatry 52: 656–658
Pineda JA, Foote SL, Neville HJ (1989) Effects of locus coeruleus lesions on auditory, long-latency, event-related potentials in monkey. J Neurosci 9: 81–93
Pritchard WS, Raz N, August GJ (1987) No effect of chronic fenfluramine on the P300 component of the event-related potential. Int J Neurosci 35: 105–110
Puce A, Kalnins RM, Berkovic SF, Donnan GA, Bladin PF (1989) Limbic P3 potentials, seizure localization, and surgical pathology in temporal lobe epilepsy. Ann Neurol 26: 377–385
Reisberg B, Ferris SH, de Lean MJ, Crook T (1982) Global deterioration scale (GDS) for age-association cognitive and Alzheimer's disease. In: Reisberg B (ed) Alzheimer's disease. The free press, New York, pp 1136–1139
Rockstroh B, Elbert T, Canavan A, Lutzenberger W, Birbaumer N (1989) Slow cortical potentials and behaviour. Urban & Schwarzenberg, Baltimore Munich Vienna
Rosenberg GA, Appenzeller O (1988) Amantadine, fatigue, and multiple sclerosis. Arch Neurol 45: 1104–1106
Roth WT, Duncan CC, Pfefferbaum A, Timsit-Berthier M (1986) Application of cognitive ERPs in psychiatric patients. In: McCallum WC, Zappoli R, Denoth F (eds) Cerebral psychophysiology: studies in event related-potentials. Elsevier, Amsterdam New York Oxford, pp 419–438
Rösler F, Manzey D, Sojka B, Stieglitz RD (1985) Delineation of pharmacopsychological effects by means of endogenous event-related brain potentials: an exemplification with Flupentixol. Neuropsychobiology 13: 81–92
Rösler F, Sutton S, Johnson R, Mulder JG, Fabiani M, Plooij-Van Gorsel E, Roth WT (1986) Endogenous ERP components and cognitive constructs. A review. In: McCallum WC, Zappoli R, Denoth F (eds) Cerebral psychophysiology: studies in event-related potentials. Elsevier, Amsterdam New York Oxford, pp 51–92
Saletu B (1976) Psychopharmaka, Gehirntätigkeit und Schlaf. Karger, Basel
Saletu B (1987) The use of pharmaco-EEG in drug profiling. In: Hindmarch I, Stonier PD (eds) Human psychompharmacology, measures and methods, vol 1. Wiley, Chichester New York Brisbane Toronto Singapore, pp 173–200
Saletu B, Anderer P, Kinsperger K, Grünberger J (1987) Topographic brain mapping of EEG in neuropsychopharmacology. Part II. Clinical applications (pharmaco EEG imaging). Methods Find Exp Clin Pharmacol 9: 385–408
Saletu B, Semlitsch HV, Anderer P, Resch F, Presslich O, Schuster P (1989) Psychophysiological research in psychiatry and neuropsychopharmacology. II. The investigation of antihypoxidotic/nootropic drugs (tenilsetam and co-dergocrine-mesylate) in elderlies with the Viennese Psychophysiological Test-System (VPTS). Methods Find Exp Clin Pharmacol 11: 43–55
Saletu B, Anderer P, Semlitsch HV, Linzmayer L, Grünberger J (1992) Amantadine infusion in mild dementia: acute double-blind placebo-cotrolled EEG mapping and psychometric studies. Arch Gerontol Geriatr (in press)
Semlitsch HV, Anderer P, Schuster P, Presslich O (1986) A solution for reliable and valid reduction of ocular artifacts, applied to the P300 ERP. Psychophysiology 23: 695–703
Semlitsch HV, Anderer P, Saletu B, Resch F, Presslich O, Schuster P (1989) Psychophysiological research in psychiatry an neuropsychopharmacology. Part I. Methodological aspects of the Viennese Psychophysiological Test-System (VPTS). Methods Find Exp Clin Pharmacol 11: 25–41
Semlitsch HV, Anderer P, Saletu B, Hochmayer I (1991) Topographic mapping of Cognitive Event Related Potentials in a double-blind, placebo-controlled study with the hemoderivative Actovegin in Age-Associated Memory Impairment. Neuropsychobiology 24: 49–56
Shader RI, Harmatz JS, Salzman C (1974) A new scale for clinical assessment in geriatric populations: Sandoz Clinical Assessment Geriatric (SCAG). J Am Geriatr Soc 22: 107–113
Simons RF, Russo KR, Hoffmann JE (1988) Event-related potentials and eye-movement relationships during psychophysical judgments: the biasing effect of rejected trials. J Psychophysiol 2: 27–37
Smith ME, Halgren E, Sokolik M, Baudena P, Musolino A, Liegeois-Chauvel C, Chauvel P (1990) The intracranial topography of the P3 event-related potential elicited during auditory oddball. Electroencephalogr Clin Neurophysiol 76: 235–248
Sokoloff P, Giros B, Martres M-P, Bouthenet M-L, Schwartz J-C (1990) Molecular cloning and characterization of a novel dopamin receptor (D3) as a target for neuroleptics. Nature 347: 146–151
Squires NK, Squires KC, Hillyard SA (1975) Two varieties of long-latency positive waves evoked by unpredictable auditory stimuli in man. Electroencephalogr Clin Neurophysiol 38: 387–401
Stern JA, Walrath LC, Goldstein R (1984) The endogenous eyeblink. Psychophysiology 21: 22–33
Tallroth G, Lindgren M, Stenberg G, Rosen I, Agardh CD (1990) Neurophysiological changes during insulin-induced hypoglycaemia and in the recovery period following glucose infusion in type 1 (insulin-dependent) diabetes mellitus and in normal man. Diabetologia 33: 319–323
Teo RKC, Ferguson DA (1986) The acute effects of ethanol on auditory event-related potentials. Psychopharmacology 90: 179–184
Terzano MJ, Montonari E, Calzetti S (1983) The effect of amantadine on arousal an EEG patterns in Creutzfeldt-Jakob disease. Arch Neurol 40: 555–559
Vardi J, Streifler M (1975) On synchronizing effect of amantadine-1-hydrochloride (Symmetrel) on pathological EEG activity. J Neural Transm 37: 73–73
Walsleben JA, Squires NK, Rothenberger VL (1989) Auditory event-related potentials and brain dysfunction in sleep apnea. Electroencephalogr Clin Neurophysiol 74: 297–311
Wasch HH, Estrin WJ, Yip P, Bowler R, Cone JE (1989) Prolongation of the P300 latency associated with hydrogen sulfide exposure. Arch Neurol 46: 902–904
Weissenborn K, Scholz M, Hinrichs H, Wiltfang J, Schmidt FW, Künkel H (1990) Neurophysiological assessment of early hepatic encephalopathy. Electroencephalogr Clin Neurophysiol 75: 289–295
Wesensten NJ, Badia P, Harsh J (1990) Time of day, repeated testing, and interblock interval effect on P300 amplitude. Physiol Behav 47: 653–658
Whalley LJ (1989) Drug treatments of dementia. Br J Psychiatry 155: 595–611
Wilcox JA, Tsuang J (1990) Psychological effects of amantadine on psychotic subjects. Pharmacopsychiatry 23: 144–146
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Semlitsch, H.V., Anderer, P. & Saletu, B. Topographic mapping of long latency “cognitive” event-related potentials (P 300): a double-blind, placebo-controlled study with amantadine in mild dementia. J Neural Transm Gen Sect 4, 319–336 (1992). https://doi.org/10.1007/BF02260080
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DOI: https://doi.org/10.1007/BF02260080