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Comparative in vitro activity of RO 23-6240 (Fleroxacin), a new 4-quinolone derivative

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Abstract

The in vitro activity of RO 23-6240 was compared with that of norfloxacin, ofloxacin and ciprofloxacin as well as four other antimicrobial agents against 345 recent clinical isolates. The MICs of RO 23-6240 againstEnterobacteriaceae andAcinetobacter anitratum was ⩽0.5mg/l. At the same concentration of the compound 90% of staphylococci were inhibited. AgainstEnterococcm faecalis andPseudomonas aeruginosa RO 23-6240 proved less active, having MIC90 values of 4.0 mg/l and 8.0 mg/l, respectively.Enterobacteriaceae and staphylococci strains that were resistant to piperacillin, cefotaxime or tobramycin were susceptible to the compound. In general the activity of RO 23-6240 was comparable to those of norfloxacin and ofloxacin, but less than that of ciprofloxacin.

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References

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Authors and Affiliations

  1. Institute of Medical Microbiology, Technical University of Munich, Ismaningerstr. 22, 8000, Munich 80, FRG

    K. Machka & I. Braveny

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  1. K. Machka
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  2. I. Braveny
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Machka, K., Braveny, I. Comparative in vitro activity of RO 23-6240 (Fleroxacin), a new 4-quinolone derivative. Eur. J, Clin. Microbiol. 6, 482–485 (1987). https://doi.org/10.1007/BF02013116

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  • DOI: https://doi.org/10.1007/BF02013116

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