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Genetic control of drug resistance: Assignment ofama-1 to Chinese hamster chromosome 7, confirmation of assignment of genes coding for TK, GALK, and ACP to chromosome 7, and tentative assignment of TPI to chromosome 8

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Somatic Cell Genetics

Abstract

The gene which specifies a subunit of RNA polymerase II, ama-1,is assigned to chromosome 7 in the Chinese hamster. The assignment of genes coding for TK, GALK, and ACP to chromosome 7 is confirmed, with a provisional regional assignment of TK and GALK to 7q. On the basis of one clone with six subclones, a provisional assignment of TPI to Chinese hamster chromosome 8 is made. With the assignment of tkand ama-1to chromosome 7 in the CHO cell line Amal, this chromosome is shown to have two selectable markers.

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Authors and Affiliations

  1. Department of Human Genetics, Yale University, 06511, New Haven, Connecticut

    Michele Roberts & Frank H. Ruddle

  2. Department of Biology, Johns Hopkins University, 21218, Baltimore, Maryland

    George A. Scangos

  3. Department of Biology, Yale University, 06511, New Haven, Connecticut

    John T. Hart & Frank H. Ruddle

Authors
  1. Michele Roberts
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  2. George A. Scangos
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  3. John T. Hart
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  4. Frank H. Ruddle
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Roberts, M., Scangos, G.A., Hart, J.T. et al. Genetic control of drug resistance: Assignment ofama-1 to Chinese hamster chromosome 7, confirmation of assignment of genes coding for TK, GALK, and ACP to chromosome 7, and tentative assignment of TPI to chromosome 8. Somat Cell Mol Genet 9, 235–248 (1983). https://doi.org/10.1007/BF01543179

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  • DOI: https://doi.org/10.1007/BF01543179

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