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Effect of N,N′-bis(methylisatin-β-thiosemicarbazone)-2-methylpiperazine on vaccinia virus replicationin vitro andin vivo

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Summary

The inhibitory effect of N,N′-bis(methylisatin-β-thiosemicarbazone)-2-methylpiperazine (compound TSKI-VI) and methisazone (Marboran) on the growth of vaccinia virus (IHD strain) was studiedin vitro andin vivo. The therapeutic indices of both compounds determinedin vivo were similar, but TSKI-VI was found more efficientin vitro.

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Authors and Affiliations

  1. Department of Virology, Institute of Microbiology, Kraków, Poland

    J. Borysiewicz & W. Witaliński

  2. Department of Comparative Anatomy, Jagellonian University, Kraków, Poland

    J. Borysiewicz & W. Witaliński

Authors
  1. J. Borysiewicz
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  2. W. Witaliński
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Borysiewicz, J., Witaliński, W. Effect of N,N′-bis(methylisatin-β-thiosemicarbazone)-2-methylpiperazine on vaccinia virus replicationin vitro andin vivo . Archives of Virology 62, 83–86 (1979). https://doi.org/10.1007/BF01314907

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  • DOI: https://doi.org/10.1007/BF01314907

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