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Effect of tetanus toxin on noradrenalin liberation from rat brain synaptosomes

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

A purified preparation of tetanus toxin (TT) (80–800 MLD/mg protein) was shown to induce liberation of both endogenous and exogenous (labeled with14C) noradrenalin (NA) from isolated nerve endings (synaptosomes) of the rat brain. Within the range of concentrations studied TT does not inhibit secretion of NA evoked by depolarization of synaptosomes by different methods in vitro.

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Authors and Affiliations

  1. Academy of Medical Sciences of the USSR, USSR

    G. N. Kryzhanovskii (Corresponding Member)

Authors
  1. G. N. Kryzhanovskii
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  2. V. I. Rodina
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  3. R. N. Glebov
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  4. A. S. Bazyan
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Additional information

Laboratory of General Pathology of the Nervous System, Institute of General Pathology and Pathological Physiology, Academy of Medical Sciences of the USSR, Moscow. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 89, No. 2, pp. 148–150, February, 1980.

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Kryzhanovskii, G.N., Rodina, V.I., Glebov, R.N. et al. Effect of tetanus toxin on noradrenalin liberation from rat brain synaptosomes. Bull Exp Biol Med 89, 115–118 (1980). https://doi.org/10.1007/BF00830993

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  • DOI: https://doi.org/10.1007/BF00830993

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