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Search for antidiabetic and cardioprotective drugs among inhibitors of β-oxidation (a review of the literature)

  • Molecular Biological Problems of the Creation of Drugs and Study of the Mechanism of their Action
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Literature cited

  1. Ya. L. Briede, R. A. Ozola, B. Z. Simkhovich, et al., Urgent Problems of the Pharmacology and Toxicoloy of Neurotropic Agents [in Russian], Riga (1986), pp. 114–118.

  2. M. M. Veveris and A. A. Kimenis, Urgent Problems of the Pharmacology and Toxicology of Neurotropic Agents [in Russian], Riga (1986), pp. 118–122.

  3. T. N. Molodchina, Zh. V. Shutenko, 10th Conference of Young Scientists: Synthesis and Investigation of Biologically Active Compounds: Summaries of Reports [in Russian], Riga (1989), p. 69.

  4. USA Patent 4324796 (1981); Chem. Abstr.,95, 80703 (1981).

  5. USA Patent No. 4337267 (1982); Chem. Abstr.,97, 182187 (1982).

  6. B. Z. Simkhovich, R. O. Vitolinya, M. R. Romanova, et al., Izv. Akad. Nauk LatvSSR, No. 6, No. 479, 106–110 (1987).

    Google Scholar 

  7. B. Z. Simkhovich, R. A. Vitolinya, M. I. Stivrinya, et al., Kardiologiya,27, No. 7, 85–88 (1987).

    Google Scholar 

  8. B. Z. Simkhovich, D. V. Meirena, Zh. V. Shutenko, et al., Vopr. Med. Khim.,34, No. 5, 30–34 (1988).

    Google Scholar 

  9. A. I. Toleikis, A. Yu. Trumpitskas, and A. K. Prashkavichyus, Vopr. Med. Khim.,32, No. 4, 76–80 (1986).

    Google Scholar 

  10. Zh. V. Shutenko, B. Z. Simkhovich, D. V. Meirena, et al., Izv. Akad. Nauk Latv. SSSR,479, No. 6, 102–105 (1987).

    Google Scholar 

  11. Zh. V. Shutenko, Regulation of Myocardial Metabolism by a Structural Analog of γ-Butyrobetaine, Mildronate. Author's Abstract of Dissertation for the Degree of Candidate of Biological Sciences [in Russian], Tartu (1988).

  12. Zh. V. Shutenko, B. Z. Simkhovich, I. Ya. Kalvin'sh, and É. Ya. Lukevits, Izv. Akad. Nauk LatvSSR,496, No. 11, 117–119 (1988).

    Google Scholar 

  13. Zh. V. Shutenko, B. Z. Simkhovich, R. Ya. Mezhapuke, et al., Izv. AKad. Nauk LatvSSR,496, No. 11, 120–123 (1988).

    Google Scholar 

  14. Zh. V. Shutenko, B. Z. Simkhovich, D. V. Meirena, et al., Vopr. Med. Khim.,35, No. 2, 59–64 (1989).

    Google Scholar 

  15. Zh. V. Shutenko, B. Z. Simkhovich, I. A. Priedena, et al., Izv. Akad. Nauk LatvSSR,511, No. 2, 65–67 (1990).

    Google Scholar 

  16. R. J. Adams, D. W. Cohen, S. Gupte, et al., J. Biol. Chem.,254, No. 23, 12404–12410 (1979).

    Google Scholar 

  17. A. Albertini and R. Ferrari, Calcium Modulators, Elsevier Biomedical Press (1982), pp. 5–16.

  18. L. Atkonson, G. Bergman, N. Jackson, et al., Br. J. Pharmacol.,66, No. 3, 444–450 (1979).

    Google Scholar 

  19. P. Avogaro, G. Bittolo Bon, G. Gazzolato, and E. Rozai, Pharmacol. Res. Commun.,13, No. 13, 433–450 (1981).

    Google Scholar 

  20. E. Bachmann and E. Weber, Pharmacol.,36, No. 4, 238–248 (1988).

    Google Scholar 

  21. J. J. Barnish, P. E. Cross, J. P. Danilewicz, et al., J. Med. Chem.,24, No. 4, 399–404 (1981).

    Google Scholar 

  22. M. C. Beatrice and D. R. Pfeiffer, Biochem. J.,199, No. 1, 71–77 (1981).

    Google Scholar 

  23. M. Beneking, M. Oellerich, R. Haeckel, and L. Binder, J. Clin. Chem. Clin. Biochem.,25, No. 8, 467–471 (1987).

    Google Scholar 

  24. G. Bergman, L. Atkison, J. Metcalf, et al., Eur. Heart J.,1, No. 2, 247–254 (1980).

    Google Scholar 

  25. A. K. M. J. Bhuiyan, K. Bartlett, H. A. S. Sherratt, and L. Agius, Biochem. J.,253, No. 2, 337–343 (1988).

    Google Scholar 

  26. R. J. Bing, Physiol. Rev.,45, No. 2, 171–250 (1965).

    Google Scholar 

  27. K. J. Blackburn, R. A. Burges, D. G. Gardiner, et al., Br. J. Pharmacol.,66, No. 3, 443–443 (1979).

    Google Scholar 

  28. A. J. Bone, H. S. A. Sherratt, D. M. Turnbull, and H. Osmundsen, Biochem. Biophys. Res. Commun.,104, No. 2, 708–712 (1982).

    Google Scholar 

  29. H. Böhles, Th. Noppeney, Z. Akcetin, et al., Current Ther. Res.,39, No. 5, 429–435 (1986).

    Google Scholar 

  30. P. Brecher, Mol. Cell. Biochem.,57, No. 1, 3–15 (1983).

    Google Scholar 

  31. J. Bremer, Physiol. Rev.,63, No. 9, 1420–1480 (1983).

    Google Scholar 

  32. J. Bremer and H. Osmundsen, Numa S, Fatty Acid Metabolism and Its Regulation, Elsevier Sci. Publ. B. V., Amsterdam (1984), pp. 113–153.

    Google Scholar 

  33. J. T. Brosnan, B. Kopec, and J. B. Fritz, J. Biol. Chem.,248, No. 11, 4075–4082 (1973).

    Google Scholar 

  34. R. A. Burges, D. G. Gardiner, and A. J. Higgins, Life Sci.,29, No. 18, 1847–1855 (1981).

    Google Scholar 

  35. P. B. Corr, D. W. Snyder, W. A. Crafford, et al., Circ. Res.,49, No. 2, 354–363 (1981).

    Google Scholar 

  36. P. B. Corr, R. W. Gross, B. E. Sobel, Circ. Res.,55, No. 1, 135–154 (1984).

    Google Scholar 

  37. J. V. Deaciuc, H. J. Kühnle, K. M. Strauss, and J. H. Schmidt, Biochem. Pharmacol.,32, No. 22, 3405–3412 (1983).

    Google Scholar 

  38. E. Downar, M. J. Janse, and D. Durrer, Circulat.,56, No. 1, 217–224 (1977).

    Google Scholar 

  39. J. P. Draye and J. Vamecq, J. Biochem.,102, No. 1, 235–242 (1987).

    Google Scholar 

  40. P. J. Eacho, P. S. Foxworthy, Biochem. Biophys. Res. Commun.,157, No. 3, 1148–1153 (1988).

    Google Scholar 

  41. K. Eistetter and H. P. O. Wolf, J. Med. Chem.,25, No. 2, 109–113 (1982).

    Google Scholar 

  42. A. Fleckenstein, Calcium and the Heart, Academic Press, London, New York (1971), pp. 135–188.

    Google Scholar 

  43. J. B. Fritz, Am. J. Physiol.,197, No. 2, 297–304 (1959).

    Google Scholar 

  44. P. Greaves, J. Martin, M. C. Michel, and P. Monpon, Archs. Toxicol., Suppl. 7, 488–493 (1984).

    Google Scholar 

  45. R. Haeckel and M. Oellerich, Eur. J. Clin. Invest.,7, No. 5, 393–400 (1977).

    Google Scholar 

  46. R. Haeckel and M. Oellerich, Horm. Metab. Res.,11, No. 11, 606–611 (1979).

    Google Scholar 

  47. R. Haeckel and M. Oellerich, Biochem. Soc. Trans.,7, No. 4, 749–752 (1979).

    Google Scholar 

  48. P. Harris, R. J. Bing, and A. Fleckenstein, Recent Advances in Studies on Cardiac Structure and Metabolism, Vol. 8, Univ. Park Press, Baltimore (1976), pp. 13–21.

    Google Scholar 

  49. P. Harris, R. J. Bing, and A. Fleckenstein, Recent Advances in Studies on Cardiac Structure and Metabolism, Vol. 8, Univ. Park Press, Baltimore (1976), pp. 153–156.

    Google Scholar 

  50. H. Hayashi, Y. Suzuki, Y. Masumura, et al., Jpn. Heat J.,23, No. 6, 623–630 (1982).

    Google Scholar 

  51. A. Helenius and K. Simons, Biochim. Biophys. Acta,415, No. 1, 29–79 (1975).

    Google Scholar 

  52. A. J. Higgins, M. Morville, R. A. Burges, et al., Life Sci.,27, No. 11, 963–970 (1980).

    Google Scholar 

  53. A. J. Higgins, M. Morville, A. B. Roger, and K. J. Blackburn, Biochem. Biophys. Res. Comun.,100, No. 1, 291–296 (1981).

    Google Scholar 

  54. A. J. Higgins, J. M. Fauccini, and P. Greaves, Adv. Myocardiol.,6, No. 3, 329–338 (1985).

    Google Scholar 

  55. B. Hoffman and F. Hucho, FEBS Lett.,43, No. 1, 116–119 (1974).

    Google Scholar 

  56. S. Horie and T. Suga, Biochem. Pharmacol.,34, No. 9, 1357–1362 (1985).

    Google Scholar 

  57. F. Hucho, D. D. Randall, T. E. Roche, et al., Arch. Biochem. Biophys.,151, No. 1, 328–340 (1972).

    Google Scholar 

  58. F. E. Hull, K. A. Waugh, M. Malone, et al., Arch. Biochem. Biophys.,149, No. 1, 69–90 (1972).

    Google Scholar 

  59. J. F. Hütter and P. G. Spieckermann, Naunun-Schmiedeberg's Arch. Pharmacol.,322, NSAPCC (Suppl.), 37–41 (1983).

    Google Scholar 

  60. J. A. Idell-Wenger, L. W. Grotyohann, and J. R. Neely, J. Biol. Chem.,253, No. 9, 4310–4318 (1978).

    Google Scholar 

  61. J. A. Idell-Wenger, L. W. Grotyohann, and J. R. Neely, J. Mol. Cell. Cardiol.,14, No. 7, 413–417 (1982).

    Google Scholar 

  62. D. L. Jenkins and O. W. Griffith, Proc. Natl. Acad. Sci. USA,83, No. 2, 290–294 (1986).

    Google Scholar 

  63. H. Jodalen, K. Ytrehus, P. Moen, et al., J. Mol. Cell. Cardiol.,20, No. 3, 277–282 (1988).

    Google Scholar 

  64. T. Kanamaru, S. Shinagava, M. Agai, et al., Life Sci.,37, No. 3, 217–223 (1985).

    Google Scholar 

  65. A. M. Katz, F. C. Messineo, and P. B. Pinto, Clin. Res.,28, 470A (1980).

    Google Scholar 

  66. A. M. Katz, F. C. Messineo, and P. B. Pinto, Circ. Res.,48, No. 1, 1–16 (1981).

    Google Scholar 

  67. J. K. Kjekshus and O. D. Mjoes, J. Clin. Invest.,51, No. 7, 1767–1776 (1972).

    Google Scholar 

  68. B. Kopec and I. B. Fritz, J. Biol. Chem.,248, No. 11, 4069–4074 (1973).

    Google Scholar 

  69. H. Korb, A. Hoeft, D. H. Hunneman, et al., J. Mol. Cell. Cardiol.,15, No. 1, 9–13 (1983).

    Google Scholar 

  70. H. Korb, A. Hoeft, D. H. Hunneman, et al., Naunyn-Schmiedeberg's Arch. Pharmacol.,327, No. 1, 70–74 (1984).

    Google Scholar 

  71. P. P. Koundkjian, D. M. Turnbull, A. J. Bone, et al., Biochem. Pharmacol.,33, No. 3, 465–473 (1984).

    Google Scholar 

  72. Y. T. Kruszynska and, Ah. H. A. Stanley, Biochem. Soc. Trans.,14, No. 4, 669–670 (1986).

    Google Scholar 

  73. V. A. Kurien and M. F. Oliver, Lancet,2, No. 7455, 122–127 (1966).

    Google Scholar 

  74. H. J. Kühnle, F. H. Schmidt, and I. V. Deaciuc, Pharmacol.,33, No. 9, 1437–1444 (1984).

    Google Scholar 

  75. K. LaNoue, W. J. Nicklas, and J. R. Williamson, J. Biol. Chem.,245, No. 1, 102–111 (1970).

    Google Scholar 

  76. A. J. Liedtke, S. Nellis, and J. R. Neeley, Circ. Res.,43, No. 4, 652–661 (1978).

    Google Scholar 

  77. M. L. K. Markwell, L. I. Bieber, and N. E. Tolbert, Biochem. Pharmacol.,26, No. 18, 1697–1702 (1977).

    Google Scholar 

  78. P. R. Maroko, P. Libby, B. E. Sobel, et al., Circulat.,45, No. 5, 1160–1168 (1972).

    Google Scholar 

  79. K. Matsui, M. Nazakawa, K. Takeda, and Sh. Imai, Jpn. J. Pharmacol.,39, No. 2, 263–270 (1985).

    Google Scholar 

  80. F. C. Messineo, P. B. Pinto, and A. M. Katz, Adv. Myocardiol.,3, No. 3, 407–415 (1982).

    Google Scholar 

  81. K. H. Moore, J. F. Radloff, F. E. Hull, and C. C. Sweely, Am. J. Physiol.,239, No. 2, H257-H265 (1980).

    Google Scholar 

  82. N. Naqvi, D. S. Thompson, S. M. Juul, et al., Eur. Heart J.,1, No. 2, 255–261 (1980).

    Google Scholar 

  83. J. R. Neely and H. E. Morgam, Ann. Rev. Physiol.,36, No. 3, 413–459 (1974).

    Google Scholar 

  84. M. Oellerich and R. Haeckel, Horm. Metab. Res.,12, No. 5, 182–189 (1980).

    Google Scholar 

  85. M. F. Oliver, Circulat.,45, No. 3, 491–500 (1972).

    Google Scholar 

  86. L. H. Opie, Am. Heart J.,76, No. 5, 685–690 (1968).

    Google Scholar 

  87. L. H. Opie, J. Mol. Cell. Cardiol.,1, No. 2, 107–115 (1970).

    Google Scholar 

  88. L. H. Opie, Am. Heart J.,97, No. 3, 375–383 (1979).

    Google Scholar 

  89. L. H. Opie, A. J. Drake-Holland, and I. M. Noble, Cardiac Metabolism, John Wiley and Sons Ltd., New York (1983), pp. 279–307.

    Google Scholar 

  90. J. F. Oram, S. L. Benetch, and J. R. Neely, J. Biol. Chem.,248, No. 18, 6299–6304 (1973).

    Google Scholar 

  91. J. V. Palmer and D. R. Pfeifer, J. Biol. Chem.,256, No. 13, 6742–6750 (1981).

    Google Scholar 

  92. S. V. Pande, J. Biol. Chem.,246, No. 10, 5381–5390 (1971).

    Google Scholar 

  93. J. R. B. Pitts, C. A. Tate, W. B. Van Winkle, et al., Life Sci.,23, No. 4, 391–401 (1978).

    Google Scholar 

  94. P. J. Randle, E. A. Newsholme, and P. B. Garland, Biochem. J.,93, No. 3, 652–665 (1964).

    Google Scholar 

  95. P. J. Randle, P. B., Garland, C. N. Hales, et al., Recent Progr. Horm. Res.,22, No. 1, 1–48 (1966).

    Google Scholar 

  96. J. K. Reddy and, S. Kumar, J. Biochem.,85, No. 3, 847–856 (1979).

    Google Scholar 

  97. P. Rösen, L. Hurberg, H. Reinauer, et al., Endocrinology,119, No. 3, 1285–1291 (1986).

    Google Scholar 

  98. V. A. Saks, R. Ventura-Clapier, L. A. Huchua, et al., Biochim. Biophys. Acta,803, No. 2, 254–264 (1984).

    Google Scholar 

  99. F. H. Schmidt, I. V. Deaciuc, and H. F. Kühnle, Life Sci.,36, No. 1, 63–67 (1985).

    Google Scholar 

  100. R. Seitelberger, O. Kraupp, A. Beek, et al., J. Cardiovasc. Pharmacol.,6, No. 5, 902–908 (1984).

    Google Scholar 

  101. R. Seitelberger, O. Kraupp, M. Winkler, et al., J. Cardiovasc. Pharmacol.,7, No. 2, 273–280 (1985).

    Google Scholar 

  102. H. S. A. Sherratt, S. Y. Gatley, T. R. De Grado, et al., Biochim. Biophys. Res. Commun.,117, No. 3, 653–657 (1983).

    Google Scholar 

  103. E. Shrago, A. L. Shug, H. Sul, et al., Circ. Res.,38, Suppl 1, 75–76 (1976).

    Google Scholar 

  104. A. L. Shug, E. Shrago, N. Bittar, et al., Am. J. Physiol.,228, No. 3, 689–692 (1975).

    Google Scholar 

  105. A. L. Shug, J. H. Thomsen, J. D. Fotts, et al., Arch. Biochem. Biophys.,187, No. 1, 25–33 (1978).

    Google Scholar 

  106. A. L. Shug, B. Hayers, P. J. Huth, et al., R. A. Frenkel, and J. D. McGarry, Carnitine Biosynthesis, Metabolism, and Function, Academic Press, New York (1980), pp. 311–340.

    Google Scholar 

  107. B. Z. Simkhovich, Zh. V. Shutenko, D. V. Meirena, et al., Biochem. Pharmacol.,37, No. 2, 195–202 (1988).

    Google Scholar 

  108. D. Sodi-Palares, M. R. Testelli, and F. L. Fishleder, Am. J. Cardiol.,9, No. 2, 166–169 (1962).

    Google Scholar 

  109. L. G. Spagnoli, M. Corsi, S. Villasehi, et al., Lancet,1, No. 8447, 165 (1982).

    Google Scholar 

  110. Y. Suzuki, Y. Masumura, A. Kobayashi, et al., Lancet,1, No. 8446, 116 (1982).

    Google Scholar 

  111. D. M. Turnbull, K. Bartlett, S. J. M. Younate, and H. S. A. Sherratt, Biochem. Pharmacol.,33, No. 3, 475–484 (1984).

    Google Scholar 

  112. S. Wakil, D. Green, S. Mii, and H. Mahler, J. Biol. Chem.,207, No. 3, 631–638 (1954).

    Google Scholar 

  113. A. Waldenstroem and A. Hjalmarson, J. Mol. Cell. Cardiol.,12, Suppl. 1, 176–181 (1980).

    Google Scholar 

  114. D. W. West, J. F. A. Chase, P. K. Tubbs, Biochem. Biophys. Res. Commun.,42, No. 5, 912–918 (1971).

    Google Scholar 

  115. J. T. Whitmer, J. A. Idell-Wemger, M. J. Rovetto, and J. R. Neely, J. Biol. Chem.,253, No. 12, 4305–4309 (1978).

    Google Scholar 

  116. H. P. O. Wolf, K. Eistetter, and G. Ludwig, Diabetologia,22, No. 6, 456–463 (1982).

    Google Scholar 

  117. H. P. O. Wolf and D. W. Engel, Eur. J. Biochem.,146. No. 2, 359–363 (1985).

    Google Scholar 

  118. J. M. Wood, B. Bush, B. J. R. Pitts, and A. Schwartz, Biochem. Biophys. Res. Commun.,74, No. 2, 677–684 (1977).

    Google Scholar 

  119. D. W. Yates and P. B. Garland, Biochem. J.,119, No. 3, 547–552 (1970).

    Google Scholar 

  120. C. M. York, C. R. Cantrell, and B. R. Borum, Arch. Biochem. Biophys.,221, No. 2, 526–533 (1983).

    Google Scholar 

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Translated from Khimiko-farmatsevitcheskii Zhurnal, Vol. 25, No. 7, pp. 4–11, July, 1991.

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Shutenko, Z.V. Search for antidiabetic and cardioprotective drugs among inhibitors of β-oxidation (a review of the literature). Pharm Chem J 25, 427–437 (1991). https://doi.org/10.1007/BF00771994

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