Summary
The dominant lethal method has been described and the control data of C3H inbred mice and (101xC3H)F1 hybrids were analysed. It could be demonstrated that infectious diseases and the number of implantations per uterus can influence the embryonic mortality. Other tested parameters such as 0.9% NaCl solution, aqua dest., and paternal and maternal age have within a certain frame no effect on the embryonic mortality. The heterogeneity does not permit a pooling of the controls and suggests on the other hand that each experiment should have a sufficient number of own controls to enable a decision over the mutagenicity of a compound.
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Röhrborn, G. Mutagenicity tests in mice. Hum Genet 6, 345–361 (1968). https://doi.org/10.1007/BF00286805
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DOI: https://doi.org/10.1007/BF00286805