Prevention of Pro-inflammatory Markers By Medicinal Mushrooms Under Stressful Environment

Maithani, Rekha; Yadav, Ronika; Sharma, Ratnika; Tulsawani, Rajkumar

doi:10.1007/978-981-99-7652-2_21

Rekha Maithani³,
Ronika Yadav³,
Ratnika Sharma³ &
…
Rajkumar Tulsawani³

93 Accesses

Abstract

Hypoxia and inflammation are vicious cycles and often difficult to point out which signal activates first, and often these signals reinforce in a feedback loop. Inflammation significantly contributes to high-altitude sickness by increasing pro-inflammatory cytokines that participate in high-altitude associated pulmonary hypertension, pulmonary edema, and cerebral edema. Two medicinal mushrooms growing at high altitude, i.e., Ganoderma lucidum and Cordyceps sinensis, play vital role in diffusing cytokine storm observed upon high-altitude exposure, and these fungus exhibit strong anti-inflammatory properties.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Chapter: USD 29.95; Price excludes VAT (USA)

eBook: USD 139.00; Price excludes VAT (USA)

Hardcover Book: USD 179.99; Price excludes VAT (USA)

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

Arias-Stella J, Saldana M (1963) The terminal portion of the pulmonary arterial tree in people native to high altitudes. Circulation 28(5):915–925. https://doi.org/10.1161/01.CIR.28.5.915
Article CAS PubMed Google Scholar
Ashraf SA, Elkhalifa AEO, Siddiqui AJ, Patel M, Awadelkareem AM, Snoussi M et al (2020) Cordycepin for health and wellbeing: a potent bioactive metabolite of an Entomopathogenic cordyceps medicinal fungus and its nutraceutical and therapeutic potential. Molecules 25(12):2735. https://doi.org/10.3390/molecules25122735
Article CAS PubMed PubMed Central Google Scholar
Bailey DM, Bärtsch P, Knauth M, Baumgartner RW (2009) Emerging concepts in acute mountain sickness and high-altitude cerebral edema: from the molecular to the morphological. Cell Mol Life Sci 66(22):3583–3594. https://doi.org/10.1007/s00018-009-0145-9
Article CAS PubMed PubMed Central Google Scholar
Belwal T, Bhatt ID, Kashyap D, Sak K, Tuli HS, Pathak R et al (2019) Ophio Cordyceps sinensis. In: Nonvitamin and nonmineral nutritional supplements. Academic Press, pp 527–537
Google Scholar
Bhosle S, Ranadive K, Bapat G, Garad S, Deshpande G, Vaidya J (2010) Taxonomy and diversity of Ganoderma from the Western parts of Maharashtra (India). Mycosphere 1:249–262
Google Scholar
Boh B, Berovic M, Zhang J, Zhi-Bin L (2007) Ganoderma lucidum and its pharmaceutically active compounds. Biotechnol Annu Rev 13:265–301. https://doi.org/10.1016/S1387-2656(07)13010-6. PMID: 17875480
Article CAS PubMed Google Scholar
Brito J, Siques P, Pena E (2020) Long-term chronic intermittent hypoxia: a particular form of chronic high-altitude pulmonary hypertension. Pulm Circ 10(1 Suppl):5–12. https://doi.org/10.1177/2045894020934625. PMID: 33110494; PMCID: PMC7557688
Article PubMed PubMed Central Google Scholar
Burke DL, Frid MG, Kunrath CL, Karoor V, Anwar A, Wagner BD et al (2009) Sustained hypoxia promotes the development of a pulmonary artery-specific chronic inflammatory microenvironment. Am J Physiol Lung Cell Mol Physiol 297(2):L238–L250. https://doi.org/10.1152/ajplung.90591.2008
Article CAS PubMed PubMed Central Google Scholar
Cai Q, Li Y, Pei G (2017) Polysaccharides from Ganoderma lucidum attenuate microglia-mediated neuroinflammation and modulate microglial phagocytosis and behavioural response. J Neuroinflammation 14(1):63. https://doi.org/10.1186/s12974-017-0839-0
Article CAS PubMed PubMed Central Google Scholar
Chang Y, Hsu WH, Lu WJ, Jayakumar T, Liao JC, Lin MJ et al (2015) Inhibitory mechanisms of CME-1, a novel polysaccharide from the mycelia of Cordyceps sinensis, in platelet activation. Curr Pharm Biotechnol 16(5):451–461. https://doi.org/10.2174/1389201016666150303152237
Article CAS PubMed Google Scholar
Chen J, Chan WM, Leung HY, Leong PK, Yan CTM, Ko KM (2020) Anti-inflammatory effects of a Cordyceps sinensis mycelium culture extract (Cs-4) on rodent models of allergic rhinitis and asthma. Molecules 25(18):4051. https://doi.org/10.3390/molecules25184051
Article CAS PubMed PubMed Central Google Scholar
Chen PX, Wang S, Nie S, Marcone M (2013) Properties of Cordyceps sinensis: a review. J Funct Foods 5(2):550–569. https://doi.org/10.1016/j.jff.2013.01.034
Article CAS PubMed PubMed Central Google Scholar
Chen W, Zhang W, Shen W, Wang K (2010) Effects of the acid polysaccharide fraction isolated from a cultivated Cordyceps sinensis on macrophages in vitro. Cell Immunol 262(1):69–74. https://doi.org/10.1016/j.cellimm.2010.01.001
Article CAS PubMed Google Scholar
Chousterman BG, Swirski FK, Weber GF (2017) Cytokine storm and sepsis disease pathogenesis. Semin Immunopathol 39(5):517–528. https://doi.org/10.1007/s00281-017-0639-8; Abstract|CrossRef Full Text|Google Scholar
Article CAS PubMed Google Scholar
Cör AD, Knez Ž, Knez MM (2022) Antioxidant, antibacterial, antitumor, antifungal, antiviral, anti-inflammatory, and nevro-protective activity of Ganoderma lucidum: an overview. Front Pharmacol 13:934982. https://doi.org/10.3389/fphar.2022.934982, PMID 35935849, PMCID PMC9353308
Article CAS Google Scholar
Costa-Rezende DH, Robleo GL, Drechsler-Santos ER, Glen M, Gates G, de Madrignac BR, et al (2020) Taxonomy and phylogeny of polypores with ganodermatoid
Google Scholar
Czepiel J, Biesiada G, Brzozowski T, Ptak-Belowska A, Perucki W, Birczynska M et al (2014) The role of local and systemic cytokines in patients infected with Clostridium difficile. J Physiol Pharmacol 65(5):695–703
CAS PubMed Google Scholar
Das G, Shin HS, Leyva-Gómez G, Prado-Audelo ML, Cortes H, Singh YD et al (2021) Cordyceps spp.: a review on its immune-stimulatory and other biological potentials. Front Pharmacol 11:2250
Article Google Scholar
Dinarello CA (2000) Proinflammatory cytokines. Chest 118(2):503–508. https://doi.org/10.1378/chest.118.2.503
Article CAS PubMed Google Scholar
Dudhgaonkar S, Thyagarajan A, Sliva D (2009) Suppression of the inflammatory response by triterpenes isolated from the mushroom Ganoderma lucidum. Int Immunopharmacol 9(11):1272–1280. https://doi.org/10.1016/j.intimp.2009.07.011
Article CAS PubMed Google Scholar
Dunham-Snary KJ, Wu D, Sykes EA, Thakrar A, Parlow LRG, Mewburn JD, Parlow JL, Archer SL (2016) Hypoxic pulmonary vasoconstriction: from molecular mechanisms to medicine. Chest 151(1):181–192. https://doi.org/10.1016/j.chest.2016.09.001. Epub 2016 Sep 16. PMID: 27645688; PMCID: PMC5310129
Article PubMed PubMed Central Google Scholar
El Alam S, Pena E, Aguilera D, Siques P, Brito J (2022) Inflammation in pulmonary hypertension and edema induced by hypobaric hypoxia exposure. Int J Mol Sci 23(20):12656. https://doi.org/10.3390/ijms232012656, PMID 36293512, PMCID PMC9604159
Article CAS PubMed PubMed Central Google Scholar
Eltzschig HK, Carmeliet P (2011) Hypoxia and inflammation. N Engl J Med 364(7):656–665. https://doi.org/10.1056/NEJMra0910283
Article CAS PubMed PubMed Central Google Scholar
Fan S, Huang X, Wang S, Li C, Zhang Z, Xie M et al (2018) Combinatorial usage of fungal polysaccharides from Cordyceps sinensis and Ganoderma atrum ameliorate drug-induced liver injury in mice. Food Chem Toxicol 119:66–72. https://doi.org/10.1016/j.fct.2018.05.027
Article CAS PubMed Google Scholar
Ferrara JL, Abhyankar S, Gilliland DG (1993) Cytokine storm of graft-versus-host disease: a critical effector role for interleukin-1. Transplant Proc 25(1 Pt 2):1216–1217
CAS PubMed Google Scholar
Frede S, Stockmann C, Freitag P, Fandrey J (2006) Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-κB. Biochem J 396(3):517–527. https://doi.org/10.1042/BJ20051839
Article CAS PubMed PubMed Central Google Scholar
Fu Y, Shi L, Ding K (2019) Structure elucidation and anti-tumor activity in vivo of a polysaccharide from spores of Ganoderma lucidum (Fr.) karst. Int J Biol Macromol 141:693–699. https://doi.org/10.1016/j.ijbiomac.2019.09.046
Article CAS PubMed Google Scholar
Furman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S, Franceschi C et al (2019) Chronic inflammation in the etiology of disease across the life span. Nat Med 25(12):1822–1832. https://doi.org/10.1038/s41591-019-0675-0, PMID 31806905, PMCID PMC7147972
Article CAS PubMed PubMed Central Google Scholar
Gallagher SA, Hackett PH (2004) High-altitude illness. Emerg Med Clin North Am 22(2):329–355. https://doi.org/10.1016/j.emc.2004.02.001
Article PubMed Google Scholar
Gao Y, Chan E, Zhou S (2004) Immunomodulating activities of Ganoderma a mushroom with medicinal properties. Food Rev Int 20(2):123–161. https://doi.org/10.1081/FRI-120037158
Article CAS Google Scholar
Geng X, Zhong D, Su L, Lin Z, Yang B (2020) Preventive and therapeutic effect of Ganoderma lucidum on kidney injuries and diseases. Adv Pharmacol 87:257–276. https://doi.org/10.1016/bs.apha.2019.10.003
Article CAS PubMed Google Scholar
Groves BM, Reeves JT, Sutton JR, Wagner PD, Cymerman A, Malconian MK et al (1987) Operation EVEREST II: elevated high-altitude pulmonary resistance unresponsive to oxygen. J Appl Physiol (1985) 63(2):521–530. https://doi.org/10.1152/jappl.1987.63.2.521
Article CAS PubMed Google Scholar
Hartmann G, Tschöp M, Fischer R, Bidlingmaier C, Riepl R, Tschöp K et al (2000) High altitude increases circulating interleukin-6, interleukin-1 receptor antagonist and C-reactive protein. Cytokine 12(3):246–252. https://doi.org/10.1006/cyto.1999.0533, PMID 10704252
Article CAS PubMed Google Scholar
Hasnat MA, Pervin M, Cha KM, Kim SK, Lim BO (2015) Anti-inflammatory activity on mice of extract of Ganoderma lucidum grown on rice via modulation of MAPK and NF-κB pathways. Phytochemistry 114:125–136. https://doi.org/10.1016/j.phytochem.2014.10.019
Article CAS PubMed Google Scholar
Hayden MS, Ghosh S (2008) Shared principles in NF-κB signaling. Cell 132(3):344–362. https://doi.org/10.1016/j.cell.2008.01.020
Article CAS PubMed Google Scholar
Hislop A, Reid L (1976) New findings in pulmonary arteries of rats with hypoxia induced pulmonary hypertension. Br J Exp Pathol 57(5):542–554
CAS PubMed PubMed Central Google Scholar
Hu H, Xiao L, Zheng B, Wei X, Ellis A, Liu YM (2015) Identification of chemical markers in Cordyceps sinensis by HPLC-MS/MS. Anal Bioanal Chem 407(26):8059–8066. https://doi.org/10.1007/s00216-015-8978-6
Article CAS PubMed PubMed Central Google Scholar
Huang D, Meran S, Nie SP, Midgley A, Junqiao W, Cui SW et al (2018) Cordyceps sinensis: anti-fibrotic and inflammatory effects of a cultured polysaccharide extract. Bioact Carbohydr Diet Fibre 14:2–8. https://doi.org/10.1016/j.bcdf.2017.07.012, ISSN 2212-6198
Article CAS Google Scholar
Imtiyaz HZ, Simon MC (2010) Hypoxia-inducible factors as essential regulators of inflammation. Curr Top Microbiol Immunol 345:105–120. https://doi.org/10.1007/82_2010_74, PMID 20517715, PMCID PMC3144567
Article CAS PubMed PubMed Central Google Scholar
Jatwani A, Tulsawani R (2021) Ganoderma lucidum induces myogenesis markers to avert damage to skeletal muscles in rats exposed to hypobaric hypoxia. High Alt Med Biol. https://doi.org/10.1089/ham.2020.0172
Jeong JW, Jin CY, Kim GY, Lee JD, Park C, Kim GD, Kim WJ, Jung WK, Seo SK, Choi IW, Choi YH (2010) Anti-inflammatory effects of cordycepin via suppression of inflammatory mediators in BV2 microglial cells. Int Immunopharmacol 10(12):1580–1586. https://doi.org/10.1016/j.intimp.2010.09.011. Epub 2010 Oct 14. PMID: 20937401
Article CAS PubMed Google Scholar
Jiang J, Grieb B, Thyagarajan A, Sliva D (2008) Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-κB signaling. Int J Mol Med 21(5):577–584
CAS PubMed Google Scholar
Joseph S, Sabulal B, George V, Antony KR, Janardhanan KK (2011) Antitumor and anti-inflammatory activities of polysaccharides isolated from Ganoderma lucidum. Acta Pharma 61(3):335–342. https://doi.org/10.2478/v10007-011-0030-6. PMID: 21945912
Article CAS Google Scholar
Jung Y, Isaacs JS, Lee S, Trepel J, Liu ZG, Neckers L (2003) Hypoxia-inducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor κB activation. Biochem J 370(3):1011–1017. https://doi.org/10.1042/BJ20021279
Article CAS PubMed PubMed Central Google Scholar
Kim SD (2010) Isolation, structure and cholesterol esterase inhibitory activity of a polysaccharide, PS-A, from Cordyceps sinensis. J Korean Soc Appl Biol Chem 53(6):784–789. https://doi.org/10.3839/jksabc.2010.118
Article CAS Google Scholar
Kim HG, Shrestha B, Lim SY, Yoon DH, Chang WC, Shin DJ et al (2006) Cordycepin inhibits lipopolysaccharide-induced inflammation by the suppression of NF-kappaB through Akt and p38 inhibition in RAW 264.7 macrophage cells. Eur J Pharmacol 545(2–3):192–199. https://doi.org/10.1016/j.ejphar.2006.06.047
Article CAS PubMed Google Scholar
Koo MH, Chae HJ, Lee JH, Suh SS, Youn UJ (2021) Antiinflammatory lanostane triterpenoids from Ganoderma lucidum. Nat Prod Res 35(22):4295–4302. https://doi.org/10.1080/14786419.2019.1705815
Article CAS PubMed Google Scholar
Kubo K, Hanaoka M, Hayano T, Miyahara T, Hachiya T, Hayasaka M et al (1998) Inflammatory cytokines in BAL fluid and pulmonary hemodynamics in high-altitude pulmonary edema. Respir Physiol 111(3):301–310. https://doi.org/10.1016/s0034-5687(98)00006-1
Article CAS PubMed Google Scholar
Kuo YC, Tsai WJ, Shiao MS, Chen CF, Lin CY (1996) Cordyceps sinensis as an immunomodulatory agent. Am J Chin Med 24(2):111–125. https://doi.org/10.1142/S0192415X96000165
Article CAS PubMed Google Scholar
Kuo YC, Tsai WJ, Wang JY, Chang SC, Lin CY, Shiao MS (2001) Regulation of bronchoalveolar lavage fluids cell function by the immunomodulatory agents from Cordyceps sinensis. Life Sci 68(9):1067–1082. https://doi.org/10.1016/s0024-3205(00)01011-0. PMID: 11212870
Article CAS PubMed Google Scholar
Lange M, Nakano Y, Traber DL, Hamahata A, Traber LD, Enkhbaatar P (2012) Time course of the inflammatory and oxidative stress response to pulmonary infection in mice. Exp Lung Res 38(3):157–163. https://doi.org/10.3109/01902148.2012.663453
Article CAS PubMed Google Scholar
Li SP, Li P, Dong TT, Tsim KW (2011) Anti-oxidation activity of different types of natural Cordyceps sinensis and cultured Cordyceps mycelia. Phytomedicine 8(3):207–212. https://doi.org/10.1078/0944-7113-00030. PMID: 11417914
Article Google Scholar
Li LQ, Song AX, Wong WT, Wu JY (2021) Isolation and assessment of a highly-active anti-inflammatory exopolysaccharide from mycelial fermentation of a medicinal fungus Cs-HK1. Int J Mol Sci 22(5):2450. https://doi.org/10.3390/ijms22052450, PMID 33671052, PMCID PMC7957654
Article CAS PubMed PubMed Central Google Scholar
Li LQ, Song AX, Yin JY, Siu KC, Wong WT, Wu JY (2020) Anti-inflammation activity of exopolysaccharides produced by a medicinal fungus Cordyceps sinensis Cs-HK1 in cell and animal models. Int J Biol Macromol 149:1042–1050. https://doi.org/10.1016/j.ijbiomac.2020.02.022
Article CAS PubMed Google Scholar
Liu CQ, Zheng AJ, Li DJ, Cao QS (2007) Improvement of immunity in mice by ultra-fine pulverization of Cordyceps militaris. Jiangsu J Agric Sci 1:63–66
Google Scholar
Liu YW, Gao JL, Guan J, Qian ZM, Feng K, Li SP (2009) Evaluation of antiproliferative activities and action mechanisms of extracts from two species of Ganoderma on tumor cell lines. J Agric Food Chem 57(8):3087–3093. https://doi.org/10.1021/jf900011f. PMID: 19368349
Article CAS PubMed Google Scholar
Liu Z, Li P, Zhao D, Tang H, Guo J (2011) Anti-inflammation effects of Cordyceps sinensis mycelium in focal cerebral ischemic injury rats. Inflammation 34(6):639–644. https://doi.org/10.1007/s10753-010-9273-5
Article PubMed Google Scholar
Liu Y, Wang J, Wang W, Zhang H, Zhang X, Han C (2015) The chemical constituents and pharmacological actions of Cordyceps sinensis. Evid Based Complement Alternat Med 2015:575063. https://doi.org/10.1155/2015/575063, PMCID. PMC4415478, 1
Article PubMed PubMed Central Google Scholar
Luks AM, Swenson ER, Bärtsch P (2017) Acute high-altitude sickness. Eur Respir Rev 26(143):160096. https://doi.org/10.1183/16000617.0096-2016
Article PubMed PubMed Central Google Scholar
Maston LD, Jones DT, Giermakowska W, Resta TC, Ramiro-Diaz J, Howard TA et al (2018) Interleukin-6 trans-signaling contributes to chronic hypoxia-induced pulmonary hypertension. Pulm Circ 8(3):2045894018780734. https://doi.org/10.1177/2045894018780734, (PMC Free article). PMID 29767573
Article CAS PubMed PubMed Central Google Scholar
Mehta SR, Chawla A, Kashyap AS (2008) Acute mountain sickness, high altitude cerebral oedema, high altitude pulmonary oedema: the current concepts. Med J Armed Forces India 64(2):149–153. https://doi.org/10.1016/S0377-1237(08)80062-7
Article CAS PubMed PubMed Central Google Scholar
Min BS, Nakamura N, Miyashiro H, Bae KW, Hattori M (1998) Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 protease. Chem Pharm Bull (Tokyo) 46(10):1607–1612. https://doi.org/10.1248/cpb.46.1607. PMID: 9810695
Article CAS PubMed Google Scholar
Olatunji OJ, Tang J, Tola A, Auberon F, Oluwaniyi O, Ouyang Z (2018) The genus Cordyceps: an extensive review of its traditional uses, phytochemistry and pharmacology. Fitoterapia 129:293–316. https://doi.org/10.1016/j.fitote.2018.05.010
Article CAS PubMed Google Scholar
Patel H, Zaghloul N, Lin K, Liu SF, Miller EJ, Ahmed M (2017) Hypoxia-induced activation of specific members of the NF-kB family and its relevance to pulmonary vascular remodeling. Int J Biochem Cell Biol 92:141–147. https://doi.org/10.1016/j.biocel.2017.09.022, PMID 28987523
Article CAS PubMed Google Scholar
Petruzzello M (2022) Ganoderma. In: Encyclopaedia Britannica; [cited Jun 29 2023]. https://www.britannica.com/science/Ganoderma
Google Scholar
Pham K, Parikh K, Heinrich EC (2021) Hypoxia and inflammation: insights from high-altitude physiology. Front Physiol 12:676782. https://doi.org/10.3389/fphys.2021.676782, PMID 34122145, PMCID PMC8188852
Article PubMed PubMed Central Google Scholar
Qian GM, Pan GF, Guo JY (2012) Anti-inflammatory and antinociceptive effects of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis. Nat Prod Res 26(24):2358–2362. https://doi.org/10.1080/14786419.2012.658800. Epub 2012 Feb 21. PMID: 22348255
Article CAS PubMed Google Scholar
Shahed AR, Kim SI, Shoskes DA (2001) Down-regulation of apoptotic and inflammatory genes by Cordyceps sinensis extract in rat kidney following ischemia/reperfusion. Transplant Proc 33(6):2986–2987. https://doi.org/10.1016/s0041-1345(01)02282-5
Article CAS PubMed Google Scholar
Sharma C, Bhardwaj N, Sharma A, Tuli HS, Batra P, Beniwal V et al (2019b) Bioactive metabolites of Ganoderma lucidum: factors, mechanism and broad spectrum therapeutic potential. J Herb Med 17:100268
Article Google Scholar
Sharma P, Tulsawani R (2020) Ganoderma lucidum aqueous extract prevents hypobaric hypoxia induced memory deficit by modulating neurotransmission, neuroplasticity and maintaining redox homeostasis. Sci Rep 10(1):8944. https://doi.org/10.1038/s41598-020-65812-5, PMID 32488040, PMCID PMC7265456
Article CAS PubMed PubMed Central Google Scholar
Sharma P, Tulsawani R (2022) Efficacy of aqueous extract of Chinese caterpillar mushroom Ophio Cordyceps sinensis (Ascomycota) against simulated altitude stress and subacute toxicity studies. Int J Med Mushrooms 24(11):21–34. https://doi.org/10.1615/IntJMedMushrooms.2022045194
Article PubMed Google Scholar
Sharma P, Tulsawani R, Agrawal U (2019a) Pharmacological effects of Ganoderma lucidum extract against high-altitude stressors and its subchronic toxicity assessment. J Food Biochem 43(12):e13081. https://doi.org/10.1111/jfbc.13081
Article PubMed Google Scholar
Shashidhar MG, Giridhar P, Udaya Sankar K, Manohar B (2013) Bioactive principles from Cordyceps sinensis: a potent food supplement–a review. J Funct Foods 5(3):1013–1030. https://doi.org/10.1016/j.jff.2013.04.018
Article CAS PubMed PubMed Central Google Scholar
Shay JE, Simon MC (2012) Hypoxia-inducible factors: crosstalk between inflammation and metabolism. Semin Cell Dev Biol 23(4):389–394. https://doi.org/10.1016/j.semcdb.2012.04.004, PMID 22525300
Article CAS PubMed Google Scholar
Sheena N, Ajith TA, Janardhanan KK (2003) Anti-inflammatory and anti[1]nociceptive activities of Ganoderma lucidum occurring in South India. Pharm Biol 41(4):301–304. https://doi.org/10.1076/phbi.41.4.301.15677
Article Google Scholar
Sheu JR, Chen ZC, Hsu MJ, Wang SH, Jung KW, Wu WF et al (2018) CME-1, a novel polysaccharide, suppresses iNOS expression in lipopolysaccharide-stimulated macrophages through ceramide-initiated protein phosphatase 2A activation. J Cell Mol Med 22(2):999–1013. https://doi.org/10.1111/jcmm.13424, PMID 29214724, PMCID PMC5783865
Article CAS PubMed Google Scholar
Sliva D (2006) Ganoderma lucidum in cancer research. Leuk Res 30(7):767–768. https://doi.org/10.1016/j.leukres.2005.12.015
Article PubMed Google Scholar
Singh M, Tulsawani R, Koganti P, Chauhan A, Manickam M, Misra K (2013) Cordyceps sinensis increases hypoxia tolerance by inducing heme oxygenase-1 and metallothionein via Nrf2 activation in human lung epithelial cells. Biomed Res Int 2013:569206. https://doi.org/10.1155/2013/569206, PMID 24063008, PMCID PMC3770031, 1
Article CAS PubMed PubMed Central Google Scholar
Song TT, Bi YH, Gao YQ, Huang R, Hao K, Xu G et al (2016) Systemic pro-inflammatory response facilitates the development of cerebral edema during short hypoxia. J Neuroinflammation 13(1):63. https://doi.org/10.1186/s12974-016-0528-4
Article CAS PubMed PubMed Central Google Scholar
Stenmark KR, Yeager ME, El Kasmi KC, Nozik-Grayck E, Gerasimovskaya EV, Li M et al (2013) The adventitia: essential regulator of vascular wall structure and function. Annu Rev Physiol 75:23–47. https://doi.org/10.1146/annurev-physiol-030212-183802
Article CAS PubMed Google Scholar
Su HG, Peng XR, Shi QQ, Huang YJ, Zhou L, Qiu MH (2020) Lanostane triterpenoids with anti-inflammatory activities from Ganoderma lucidum. Phytochemistry 173:112256. https://doi.org/10.1016/j.phytochem.2019.112256
Article CAS PubMed Google Scholar
Sung GH, Hywel-Jones NL, Sung JM, Luangsa-Ard JJ, Shrestha B, Spatafora JW (2007) Phylogenetic classification of Cordyceps and the clavicipitaceous fungi. Stud Mycol 57:5–59. https://doi.org/10.3114/sim.2007.57.01, PMID 18490993, PMCID PMC2104736
Article PubMed PubMed Central Google Scholar
Swenson ER (2020) Early hours in the development of high-altitude pulmonary edema: time course and mechanisms. J Appl Physiol 128(6):1539–1546. https://doi.org/10.1152/japplphysiol.00824.2019. Epub 2020 Mar 26. PMID: 32213112
Article PubMed Google Scholar
Swenson ER, Maggiorini M, Mongovin S, Gibbs JS, Greve I, Mairbäurl H, Bärtsch P (2002) Pathogenesis of high-altitude pulmonary edema: inflammation is not an etiologic factor. JAMA 287(17):2228–2235. https://doi.org/10.1001/jama.287.17.2228. Erratum in: JAMA 2002 Sep 4;288(9):1064. PMID: 11980523
Article PubMed Google Scholar
Sydykov A, Mamazhakypov A, Maripov A, Kosanovic D, Weissmann N, Ghofrani HA, Sarybaev AS, Schermuly RT (2021) Pulmonary hypertension in acute and chronic high altitude maladaptation disorders. Int J Environ Res Public Health 18(4):1692. https://doi.org/10.3390/ijerph18041692. PMID: 33578749; PMCID: PMC7916528
Article PubMed PubMed Central Google Scholar
Talbot NP, Balanos GM, Dorrington KL, Robbins PA (2004) Two temporal components within the human pulmonary vascular response to approximately 2 h of isocapnic hypoxia. J Appl Physiol 98(3):1125–1139. https://doi.org/10.1152/japplphysiol.00903.2004. Epub 2004 Nov 12. PMID: 15542574
Article PubMed Google Scholar
Turner MD, Nedjai B, Hurst T, Pennington DJ (2014) Cytokines and chemokines: at the crossroads of cell signalling and inflammatory disease. Biochim Biophys Acta 1843(11):2563–2582. https://doi.org/10.1016/j.bbamcr.2014.05.014
Article CAS PubMed Google Scholar
Wang C, Hou XX, Rui HL, Li LJ, Zhao J, Yang M et al (2018) Artificially cultivated Ophio Cordyceps sinensis alleviates diabetic nephropathy and its podocyte injury via inhibiting P2X7R expression and NLRP3 inflammasome activation. J Diabetes Res 2018:1390418. https://doi.org/10.1155/2018/1390418
Article CAS PubMed PubMed Central Google Scholar
Wang M, Kornsakulkarn J, Srichomthong K, Feng T, Liu JK, Isaka M et al (2019) Antimicrobial anthraquinones from cultures of the ant pathogenic fungus Cordyceps morakotii BCC 56811. J Antibiot (Tokyo) 72(3):141–147. https://doi.org/10.1038/s41429-018-0135-y
Article CAS PubMed Google Scholar
Wang Y, Liu D, Zhao H, Jiang H, Luo C, Wang M et al (2014) Cordyceps sinensis polysaccharide CPS-2 protects human mesangial cells from PDGF-BB-induced proliferation through the PDGF/ERK and TGF-β1/Smad pathways. Mol Cell Endocrinol 382(2):979–988. https://doi.org/10.1016/j.mce.2013.11.018
Article CAS PubMed Google Scholar
Wang Y, Wang Y, Liu D, Wang W, Zhao H, Wang M et al (2015) Cordyceps sinensis polysaccharide inhibits PDGF-BB-induced inflammation and ROS production in human mesangial cells. Carbohydr Polym 125:135–145. https://doi.org/10.1016/j.carbpol.2015.02.012
Article CAS PubMed Google Scholar
Wasser SP, Weis AL (1999) Medicinal properties of substances occurring in higher basidiomycetes mushrooms: current perspectives (review). Int J Med Mushrooms 1(1):31–62. https://doi.org/10.1615/IntJMedMushrooms.v1.i1.30
Article CAS Google Scholar
Wen L, Sheng Z, Wang J, Jiang Y, Yang B (2022) Structure of water-soluble polysaccharides in spore of Ganoderma lucidum and their anti-inflammatory activity. Food Chem 373(A):131374. https://doi.org/10.1016/j.foodchem.2021.131374
Article CAS PubMed Google Scholar
Wilkins MR, Ghofrani HA, Weissmann N, Aldashev A, Zhao L (2015) Pathophysiology and treatment of high-altitude pulmonary vascular disease. Circulation 131(6):582–590. https://doi.org/10.1161/CIRCULATIONAHA.114.006977
Article PubMed Google Scholar
Won SY, Park EH (2005) Anti-inflammatory and related pharmacological activities of cultured mycelia and fruiting bodies of Cordyceps militaris. J Ethnopharmacol 96(3):555–561. https://doi.org/10.1016/j.jep.2004.10.009
Article PubMed Google Scholar
Yan JK, Wang WQ, Wu JY (2014) Recent advances in Cordyceps sinensis polysaccharides: mycelial fermentation, isolation, structure, and bioactivities: a review. J Funct Foods 6:33–47. https://doi.org/10.1016/j.jff.2013.11.024, PMID 32362940, PMCID PMC7185505
Article CAS PubMed Google Scholar
Yang ML, Kuo PC, Hwang TL, Wu TS (2011) Anti-inflammatory principles from Cordyceps sinensis. J Nat Prod 74:1996–2000. https://doi.org/10.1021/np100902f
Article CAS PubMed Google Scholar
Yeung HW, Qing-Yi L, Qifeng Z, Go VLW (2004) Chemical and biochemical basis of the potential anti-tumor properties of Ganoderma lucidum. Curr Top Nutr Res 2:67–77
CAS Google Scholar
Yoon HM, Jang KJ, Han MS, Jeong JW, Kim GY, Lee JH et al (2013) Ganoderma lucidum ethanol extract inhibits the inflammatory response by suppressing the NF-κB and toll-like receptor pathways in lipopolysaccharide-stimulated BV2 microglial cells. Exp Ther Med 5(3):957–963. https://doi.org/10.3892/etm.2013.895, PMID 23408713, PMCID PMC3570243
Article PubMed PubMed Central Google Scholar
Yuan Q, Xie F, Tan J, Yuan Y, Mei H, Zheng Y et al (2022) Extraction, structure and pharmacological effects of the polysaccharides from Cordyceps sinensis: a review. J Funct Foods 89:104909. https://doi.org/10.1016/j.jff.2021.104909
Article CAS Google Scholar
Zhang J, Yu Y, Zhang Z, Ding Y, Dai X, Li Y (2011) Effect of polysaccharide from cultured Cordyceps sinensis on immune function and anti-oxidation activity of mice exposed to 60Co. Int Immunopharmacol 11:2251–2257. https://doi.org/10.1016/j.intimp.2011.09.019
Article CAS PubMed Google Scholar
Zhang W, Tao J, Yang X, Yang Z, Zhang L, Liu H, Wu K, Wu J (2014) Antiviral effects of two Ganoderma lucidum triterpenoids against enterovirus 71 infection. Biochem Biophys Res Commun 449(3):307–312. https://doi.org/10.1016/j.bbrc.2014.05.019. Epub 2014 May 15. PMID: 24845570
Article CAS PubMed Google Scholar
Zhang K, Liu Y, Zhao X, Tang Q, Dernedde J, Zhang J et al (2018) Anti-inflammatory properties of GLPss58, a sulfated polysaccharide from Ganoderma lucidum. Int J Biol Macromol 107(A):486–493. https://doi.org/10.1016/j.ijbiomac.2017.09.015
Article CAS PubMed Google Scholar
Zhang W, Yang J, Chen J, Hou Y, Han X (2005) Immunomodulatory and antitumour effects of an exopolysaccharide fraction from cultivated Cordyceps sinensis (Chinese caterpillar fungus) on tumour-bearing mice. Biotechnol Appl Biochem 42(1):9–15. https://doi.org/10.1042/BA20040183
Article CAS PubMed Google Scholar
Zhou Y, Huang X, Zhao T, Qiao M, Zhao X, Zhao M et al (2017) Hypoxia augments LPS-induced inflammation and triggers high altitude cerebral edema in mice. Brain Behav Immun 64:266–275. https://doi.org/10.1016/j.bbi.2017.04.013
Article CAS PubMed Google Scholar
Zhou J, Schmid T, Brüne B (2003) Tumor necrosis factor-alpha causes accumulation of a ubiquitinated form of hypoxia inducible factor-1alpha through a nuclear factor-kappaB-dependent pathway. Mol Biol Cell 14(6):2216–2225. https://doi.org/10.1091/mbc.e02-09-0598
Article CAS PubMed PubMed Central Google Scholar
Zhou X, Luo L, Dressel W, Shadier G, Krumbiegel D, Schmidtke P, Zepp F, Meyer CU (2008) Cordycepin is an immunoregulatory active ingredient of Cordyceps sinensis. Am J Chin Med 36:967–980. https://doi.org/10.1142/S0192415X08006387
Article CAS PubMed Google Scholar
Zhu JS, Halpern GM, Jones K (1998) The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis: part I. J Altern Complement Med 4(3):289–303. https://doi.org/10.1089/acm.1998.4.3-289
Article CAS PubMed Google Scholar
Ziegenbein FC, Hanssen HP, König WA (2005) Secondary metabolites from Ganoderma lucidum and Spongiporus leucomallellus. Phytochemistry 67(2):202–211. https://doi.org/10.1016/j.phytochem.2005.10.025. Epub 2005 Dec 13. PMID: 16356517
Article CAS Google Scholar

Download references

Author information

Authors and Affiliations

Defence Institute of Physiology and Allied Sciences (DIPAS), Defence Research and Development Organization (DRDO), Delhi, India
Rekha Maithani, Ronika Yadav, Ratnika Sharma & Rajkumar Tulsawani

Authors

Rekha Maithani
View author publications
You can also search for this author in PubMed Google Scholar
Ronika Yadav
View author publications
You can also search for this author in PubMed Google Scholar
Ratnika Sharma
View author publications
You can also search for this author in PubMed Google Scholar
Rajkumar Tulsawani
View author publications
You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Rajkumar Tulsawani .

Editor information

Editors and Affiliations

Defence Institute of Physiology & Allied Sciences (DIPAS), Defence Research and Development Organization (DRDO), Delhi, Delhi, India
Rajkumar Tulsawani
Department of Pharmacology, School of Pharmaceutical Education and Research (SPER), Jamia Hamdard, New Delhi, Delhi, India
Divya Vohora

Rights and permissions

Reprints and permissions

Copyright information

About this chapter

Cite this chapter

Maithani, R., Yadav, R., Sharma, R., Tulsawani, R. (2023). Prevention of Pro-inflammatory Markers By Medicinal Mushrooms Under Stressful Environment. In: Tulsawani, R., Vohora, D. (eds) Adaptation under Stressful Environments through Biological Adjustments and Interventions. Springer, Singapore. https://doi.org/10.1007/978-981-99-7652-2_21

Download citation

DOI: https://doi.org/10.1007/978-981-99-7652-2_21
Published: 18 January 2024
Publisher Name: Springer, Singapore
Print ISBN: 978-981-99-7651-5
Online ISBN: 978-981-99-7652-2
eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics