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Multi-lineage Differentiation from Hematopoietic Stem Cells

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Hematopoietic Stem Cells

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1442))

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Abstract

The hematopoietic stem cells (HSCs) have the ability to differentiate and give rise to all mature blood cells. Commitment to differentiation progressively limits the self-renewal potential of the original HSCs by regulating the level of lineage-specific gene expression. In this review, we will summarize the current understanding of the molecular mechanisms underlying HSC differentiation toward erythroid, myeloid, and lymphocyte lineages. Moreover, we will decipher how the single-cell technologies advance the lineage-biased HSC subpopulations and their differentiation potential.

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Authors and Affiliations

  1. The State Key Laboratory for Complex, Severe, and Rare Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences / Peking Union Medical College, Beijing, China

    Xiaoshuang Wang

  2. State Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences / Peking Union Medical College, Beijing, China

    Siqi Liu & Jia Yu

  3. The Institute of Blood Transfusion, Chinese Academy of Medical Sciences / Peking Union Medical College, Chengdu, China

    Xiaoshuang Wang & Jia Yu

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  2. Siqi Liu
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Correspondence to Xiaoshuang Wang or Jia Yu .

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  1. Key Laboratory of Stem Cells and Tissue Engineering (Ministry of Education), Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China

    Meng Zhao

  2. Center for Stem Cell and Regenerative Medicine and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

    Pengxu Qian

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Wang, X., Liu, S., Yu, J. (2023). Multi-lineage Differentiation from Hematopoietic Stem Cells. In: Zhao, M., Qian, P. (eds) Hematopoietic Stem Cells. Advances in Experimental Medicine and Biology, vol 1442. Springer, Singapore. https://doi.org/10.1007/978-981-99-7471-9_10

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