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Electrochemical Biosensors for Nucleic Acids Detection

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Electrochemical Biosensors for Whole Blood Analysis

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Abstract

The highly sensitive and selective detection of nucleic acids in clinical samples is of great significance to the diagnosis and prognosis of diseases. Electrochemical biosensors have been widely used in nucleic acid detection due to their advantages of fast response, simple operation, and low cost. In this chapter, we summarize the progress of electrochemical biosensors using one-dimensional, two-dimensional, and three-dimensional probes for nucleic acids detection, aiming to provide general guidance for the design of electrochemical detection methods for nucleic acids in complex matrices, such as whole blood. We also discuss the limitations and challenges in each kind of probe in terms of sensitivity, selectivity, and anti-fouling, providing ideas for further development of electrochemical biosensors for nucleic acid detection in complex matrices.

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Authors and Affiliations

  1. Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan, 430074, China

    Wenjing Chu & Mengyu Yang

  2. State Key Laboratory of Biogeology and Environmental Geology, Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan, 430074, China

    Meihua Lin & Fan Xia

Authors
  1. Wenjing Chu
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  2. Mengyu Yang
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  3. Meihua Lin
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  4. Fan Xia
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Correspondence to Meihua Lin .

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Editors and Affiliations

  1. Faculty of Materials Science & Chemistry, China University of Geosciences, Wuhan, China

    Fan Xia

  2. Faculty of Materials Science & Chemistry, China University of Geosciences, Wuhan, China

    Hui Li

  3. Faculty of Materials Science & Chemistry, China University of Geosciences, Wuhan, China

    Shaoguang Li

  4. Faculty of Materials Science & Chemistry, China University of Geosciences, Wuhan, Hubei, China

    Xiaoding Lou

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© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

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Chu, W., Yang, M., Lin, M., Xia, F. (2023). Electrochemical Biosensors for Nucleic Acids Detection. In: Xia, F., Li, H., Li, S., Lou, X. (eds) Electrochemical Biosensors for Whole Blood Analysis. Springer, Singapore. https://doi.org/10.1007/978-981-99-5644-9_8

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