Skip to main content
SpringerLink
Log in

Nanofillers in the Field of Drug Delivery System

  • Living reference work entry
  • First Online:
Handbook of Nanofillers

  • 17 Accesses

Abstract

In recent years, nanotechnology has played an important role in our lives, assisting us in different situations. Various incurable diseases such as cancer, diabetes, and hepatitis can be controlled by some nano-additives in their traditional drugs. Also, nanotechnology can lead us to increase the efficiency of different drugs and reduce the treatment costs in an unbelievable way. Due to their significant properties in different fields, such as biomedical, electrical, optical, and mechanical applications, they have attracted all the attention. In this category, nanofillers, with incredible behavior, have improved the properties in every single field, by enhancing their applications. Nanofillers have a wide range of benefits in biomedical fields as a motive for controlling the drug release rate, cell viability, sensitivity to pH, and temperature, as well as wound healing and bone regeneration. In this chapter, nanofillers and nanocomposites will be introduced and, as a brief, their applications in drug delivery systems will be discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References

  • Aaryashree, Choudhary AK, Yoshimi Y (2023) Disposable sensor chips with molecularly imprinted carbon paste electrodes for monitoring anti-epileptic drugs. Sensors 23:3271

    Article  CAS  Google Scholar 

  • Abdoli M, Sadrjavadi K, Arkan E, Zangeneh MM, Moradi S, Zangeneh A, Khaledian S (2020) Polyvinyl alcohol/gum tragacanth/graphene oxide composite nanofiber for antibiotic delivery. J Drug Deliv Sci Technol 60:102044

    Article  CAS  Google Scholar 

  • Abdollahy M, Peyman H, Roshanfekr H, Idris AO, Azizi S, Sibali LL (2023) Synthesis and characterization of a smart polymer-coated core–shell MnFe2O4@ organometallic framework for targeted drug delivery. Chem Pap 77:3897–3909

    Article  CAS  Google Scholar 

  • Adegoke O, Nsuamani ML, Daeid NN (2023) Cadmium-free silica-encapsulated molecularly imprinted AuZnCeSeS quantum dots nanocomposite as an ultrasensitive fluorescence nanosensor for methamphetamine detection. Mater Sci Semicond Process 159:107387

    Article  CAS  Google Scholar 

  • Ahmad S, Abbasi A, Manzoor K, Mangla D, Aggarwal S, Ikram S (2021) Chitosan-based bionanocomposites in drug delivery. In: Bionanocomposites in tissue engineering and regenerative medicine. Elsevier

    Google Scholar 

  • Ali M, Mir S, Abid O-U-R, Yawer MA, Ullah I (2022) Nanoclay reinforced ternary blends based on biodegradable polymers for drug delivery application. Int J Biomater

    Google Scholar 

  • Andrade-Melecio HA, Antolín-Cerón VH, Alvarado-Mendoza AG, Vázquez-Lepe M, Barrera-Rivera KA, Martínez-Richa A, Nuño-Donlucas SM (2022) Semi-continuous heterophase polymerization to synthesize poly (methacrylic acid)-based nanocomposites for drug delivery. Polymers 14:1195

    Article  CAS  Google Scholar 

  • Anirudhan T, Nair SS (2017) Deposition of gold-cellulose hybrid nanofiller on a polyelectrolyte membrane constructed using guar gum and poly (vinyl alcohol) for transdermal drug delivery. J Membr Sci 539:344–357

    Article  CAS  Google Scholar 

  • Assefi M, Ataeinaeini M, Nazari A, Gholipour A, Vertiz-Osores JJ, Calla-Vásquez KM, Al-Naqeeb BZT, Jassim KH, Kalajahi HG, Yasamineh S (2023) A state-of-the-art review on solid lipid nanoparticles as a nanovaccines delivery system. J Drug Deliv Sci Technol:104623

    Google Scholar 

  • Bera H, Kumar S, Maiti S (2018) Facile synthesis and characterization of tailor-made pectin-gellan gum-bionanofiller composites as intragastric drug delivery shuttles. Int J Biol Macromol 118:149–159

    Article  CAS  Google Scholar 

  • Bibi S, Mir S, Rehman W, Menaa F, Gul A, Alaryani FSS, Alqahtani AM, Haq S, Abdellatif MH (2022) Synthesis and in vitro/ex vivo characterizations of ceftriaxone-loaded sodium alginate/poly (vinyl alcohol) clay reinforced nanocomposites: possible applications in wound healing. Materials 15:3885

    Article  CAS  Google Scholar 

  • Buzarovska A, Dinescu S, Chitoiu L, Costache M (2018) Porous poly (L-lactic acid) nanocomposite scaffolds with functionalized TiO2 nanoparticles: properties, cytocompatibility and drug release capability. J Mater Sci 53:11151–11166

    Article  CAS  Google Scholar 

  • Carazo E, Borrego-Sánchez A, García-Villén F, Sánchez-Espejo R, Cerezo P, Aguzzi C, Viseras C (2018) Advanced inorganic nanosystems for skin drug delivery. Chem Rec 18:891–899

    Article  CAS  Google Scholar 

  • Cavallaro G, Lazzara G, Milioto S (2023) Nanocomposites based on halloysite nanotubes and sulphated galactan from red seaweed Gloiopeltis: properties and delivery capacity of sodium diclofenac. Int J Biol Macromol 234:123645

    Article  CAS  Google Scholar 

  • Cheng M, Qin Z, Hu S, Dong S, Ren Z, Yu H (2017) Achieving long-term sustained drug delivery for electrospun biopolyester nanofibrous membranes by introducing cellulose nanocrystals. ACS Biomater Sci Eng 3:1666–1676

    Article  CAS  Google Scholar 

  • Chisty AH, Rahman MM (2022) Insight of iron oxide-chitosan nanocomposites for drug delivery. In: Nanoscale engineering of biomaterials: properties and applications. Springer

    Google Scholar 

  • Chopade SS, Nangare K, Bagal V (2019) Bionanocomposite: a novel approach for drug delivery system. Int J Pharm Res Sci:10

    Google Scholar 

  • Da Silva ALD, Salgueiro AM, Fateixa S, Moreira J, Estrada AC, Gil AM, Trindade T (2012) Swelling and release properties of functional κ-carrageenan hydrogel nanocomposites. MRS Online Proc Lib 1403:164–170

    Google Scholar 

  • Deo KA, Jaiswal MK, Abasi S, Lokhande G, Bhunia S, Nguyen T-U, Namkoong M, Darvesh K, Guiseppi-Elie A, Tian L (2022) Nanoengineered ink for designing 3D printable flexible bioelectronics. ACS Nano 16:8798–8811

    Article  CAS  Google Scholar 

  • Depan D, Shah J, Misra R (2011) Controlled release of drug from folate-decorated and graphene mediated drug delivery system: synthesis, loading efficiency, and drug release response. Mater Sci Eng C 31:1305–1312

    Article  CAS  Google Scholar 

  • Devi S, Tripathi UK, Roy D, Dwivedi M (2023) Coherent loading–deloading mechanism in polymeric nanohybrid network structures. Langmuir 39:2281–2290

    Article  CAS  Google Scholar 

  • Dong M, Mao Y, Zhao Z, Zhang J, Zhu L, Chen L, Cao L (2022) Novel fabrication of antibiotic containing multifunctional silk fibroin injectable hydrogel dressing to enhance bactericidal action and wound healing efficiency on burn wound: in vitro and in vivo evaluations. Int Wound J 19:679–691

    Article  Google Scholar 

  • Fahim I, Aboulkhair N, Everitt N (2018) Nanoindentation investigation on chitosan thin films with different types of nano fillers. J Mater Sci Res:7

    Google Scholar 

  • Farkas N-I, MarincaÈ™ L, Barabás R, Bizo L, Ilea A, Turdean GL, ToÈ™a M, Cadar O, Barbu-Tudoran L (2022) Preparation and characterization of doxycycline-loaded electrospun PLA/HAP nanofibers as a drug delivery system. Materials 15:2105

    Article  CAS  Google Scholar 

  • Fey C, Betz J, Rosenbaum C, Kralisch D, Vielreicher M, Friedrich O, Metzger M, Zdzieblo D (2020) Bacterial nanocellulose as novel carrier for intestinal epithelial cells in drug delivery studies. Mater Sci Eng C 109:110613

    Article  CAS  Google Scholar 

  • Gai S, Xu J, Zhang H, Yin R, Zhang W (2020) Effects of nanofillers on the hydrolytic degradation of polyesters. Tissue Eng Part B Rev 26:484–495

    Article  CAS  Google Scholar 

  • Gandara-Loe J, Souza BE, Missyul A, Giraldo G, Tan J-C, Silvestre-Albero J (2020) MOF-based polymeric nanocomposite films as potential materials for drug delivery devices in ocular therapeutics. ACS Appl Mater Interfaces 12:30189–30197

    Article  CAS  Google Scholar 

  • Han C, Cai N, Chan V, Liu M, Feng X, Yu F (2018) Enhanced drug delivery, mechanical properties and antimicrobial activities in poly (lactic acid) nanofiber with mesoporous Fe3O4-COOH nanoparticles. Colloids Surf A Physicochem Eng Asp 559:104–114

    Article  CAS  Google Scholar 

  • Hezaveh H, Muhamad II (2012) The effect of nanoparticles on gastrointestinal release from modified κ-carrageenan nanocomposite hydrogels. Carbohydr Polym 89:138–145

    Article  CAS  Google Scholar 

  • Ivanoska-Dacikj A, Makreski P, Bogoeva-Gaceva G (2022) Fabrication of biodegradable polyurethane electrospun webs of fibers modified with biocompatible graphene oxide nanofiller. J Ind Text 51:4041S–4065S

    Article  CAS  Google Scholar 

  • Jabbar F, Abbas G, Ameer N, Akhtar MF, Shah S, Hanif M (2022) Preparation and characterization of halloysite nanotubes containing hydrogels for controlled release drug delivery of cetirizine dihydrochloride. Polym Bull 79:5417–5435

    Article  CAS  Google Scholar 

  • Jariya SI, Babu AA, Narayanan TS, Vellaichamy E, Ravichandran K (2022) Development of a novel smart carrier for drug delivery: ciprofloxacin loaded vaterite/reduced graphene oxide/PCL composite coating on TiO2 nanotube coated titanium. Ceram Int 48:9579–9594

    Article  Google Scholar 

  • Jorfi M, Foster EJ (2015) Recent advances in nanocellulose for biomedical applications. J Appl Polym Sci 132

    Google Scholar 

  • Joshi S, Sahu R, Dennis VA, Singh SR (2021) Nanofiller-enhanced soft non-Gelatin alginate capsules for modified drug delivery. Pharmaceuticals 14:355

    Article  CAS  Google Scholar 

  • Khandaker M, Alkadhem N, Progri H, Nikfarjam S, Jeon J, Kotturi H, Vaughan MB (2022) Glutathione immobilized polycaprolactone nanofiber mesh as a dermal drug delivery mechanism for wound healing in a diabetic patient. PRO 10:512

    CAS  Google Scholar 

  • Kimna C, Deger S, Tamburaci S, Tihminlioglu F (2022) Microfluidic-assisted preparation of nano and microscale chitosan based 3D composite materials: comparison with conventional methods. J Appl Polym Sci 139:e52955

    Article  CAS  Google Scholar 

  • Kouser R, Vashist A, Zafaryab M, Rizvi MA, Ahmad S (2018) pH-responsive biocompatible nanocomposite hydrogels for therapeutic drug delivery. ACS Appl Bio Mater 1:1810–1822

    Article  CAS  Google Scholar 

  • Kumari SVG, Manikandan NA, Pakshirajan K, Pugazhenthi G (2020) Sustained drug release and bactericidal activity of a novel, highly biocompatible and biodegradable polymer nanocomposite loaded with norfloxacin for potential use in antibacterial therapy. J Drug Deliv Sci Technol 59:101900

    Article  Google Scholar 

  • Lin N, Dufresne A (2014) Nanocellulose in biomedicine: current status and future prospect. Eur Polym J 59:302–325

    Article  CAS  Google Scholar 

  • Lionetto F, Espinoza-González C (2022) Emerging polymer-based nanocomposites. SAGE Publications Sage UK, London

    Book  Google Scholar 

  • Liu S, Qin S, He M, Zhou D, Qin Q, Wang H (2020) Current applications of poly (lactic acid) composites in tissue engineering and drug delivery. Compos Part B 199:108238

    Article  CAS  Google Scholar 

  • Liu H, Wang C, Sun X, Zhan C, Li Z, Qiu L, Luo R, Liu H, Sun X, Li R (2022) Silk fibroin/collagen/hydroxyapatite scaffolds obtained by 3D printing technology and loaded with recombinant human erythropoietin in the reconstruction of alveolar bone defects. ACS Biomater Sci Eng 8:5245–5256

    Article  CAS  Google Scholar 

  • Mahanta AK, Senapati S, Paliwal P, Krishnamurthy S, Hemalatha S, Maiti P (2018) Nanoparticle-induced controlled drug delivery using chitosan-based hydrogel and scaffold: application to bone regeneration. Mol Pharm 16:327–338

    Article  Google Scholar 

  • Mahanta AK, Patel DK, Maiti P (2019) Nanohybrid scaffold of chitosan and functionalized graphene oxide for controlled drug delivery and bone regeneration. ACS Biomater Sci Eng 5:5139–5149

    Article  CAS  Google Scholar 

  • Mallakpour S (2018) L. khodadadzadeh. Ultrason Sonochem 40:402

    Article  CAS  Google Scholar 

  • Mauri E, Salvati A, Cataldo A, Mozetic P, Basoli F, Abbruzzese F, Trombetta M, Bellucci S, Rainer A (2021) Graphene-laden hydrogels: a strategy for thermally triggered drug delivery. Mater Sci Eng C 118:111353

    Article  CAS  Google Scholar 

  • Meng Y, Qi Z, Jiang H, Li Z, Xiao Q, Xia Z, Yu M, Ruan X, He G, Jiang X (2022) Restrained MSUM crystallization via hydrogel composited membrane based platform for gout prevention and control. Chem Eng J 450:138155

    Article  CAS  Google Scholar 

  • Molaei MJ (2023) Magnetic two-dimensional Ca-Al layered double hydroxide/Fe3O4@ dextran nanocomposites as drug delivery systems. J Cryst Growth 611:127186

    Article  CAS  Google Scholar 

  • Nair AS, Devi S, Mandal S, Tripathi UK, Roy D, Prasad NE (2022) Insights into enzymatic degradation of physically crosslinked hydrogels anchored by functionalized carbon nanofillers. New J Chem 46:2669–2677

    Article  CAS  Google Scholar 

  • Nirbhaya V, Chaudhary C, Chauhan D, Chandra R, Kumar S (2022) Multiwalled carbon nanotube nanofiller-polyindole polymer matrix-based efficient biosensor for the rapid detection of swine flu. New J Chem 46:6201–6211

    Article  CAS  Google Scholar 

  • Olate-Moya F, Palza H (2022) Effect of graphene oxide on the pH-responsive drug release from supramolecular hydrogels. J Appl Polym Sci 139:51420

    Article  CAS  Google Scholar 

  • Oun AA, Bae AY, Shin GH, Park M-K, Kim JT (2022) Comparative study of oregano essential oil encapsulated in halloysite nanotubes and diatomaceous earth as antimicrobial and antioxidant composites. Appl Clay Sci 224:106522

    Article  CAS  Google Scholar 

  • Park S-Y, Kang J-H, Kim H-S, Hwang J-Y, Shin US (2022) Electrical and thermal stimulus-responsive nanocarbon-based 3D hydrogel sponge for switchable drug delivery. Nanoscale 14:2367–2382

    Article  CAS  Google Scholar 

  • Pourjalili N, Bagheri Marandi G, Kurdtabar M, Rezanejade Bardajee G (2022) Synthesis and characterization of double network hydrogel based on gellan-gum for drug delivery. J Macromol Sci A 59:537–549

    Article  CAS  Google Scholar 

  • Pourmadadi M, Darvishan S, Abdouss M, Yazdian F, Rahdar A, Díez-Pascual AM (2023) pH-responsive polyacrylic acid (PAA)-carboxymethyl cellulose (CMC) hydrogel incorporating halloysite nanotubes (HNT) for controlled curcumin delivery. Ind Crop Prod 197:116654

    Article  CAS  Google Scholar 

  • Radu E-R, Pandele AM, Tuncel C, Miculescu F, Voicu SI (2023) Preparation and characterization of chitosan/LDH composite membranes for drug delivery application. Membranes 13:179

    Article  CAS  Google Scholar 

  • Rahmani E, Pourmadadi M, Zandi N, Rahdar A, Baino F (2022) pH-responsive PVA-based nanofibers containing GO modified with ag nanoparticles: physico-chemical characterization, wound dressing, and drug delivery. Micromachines 13:1847

    Article  Google Scholar 

  • Rapacz-Kmita A, Szaraniec B, MikoÅ‚ajczyk M, Stodolak-Zych E, Dzierzkowska E, Gajek M, Dudek P (2020) Multifunctional biodegradable polymer/clay nanocomposites with antibacterial properties in drug delivery systems. Acta Bioeng, Biomech, p 22

    Google Scholar 

  • Roy S, Haloi P, Choudhary R, Chawla S, Kumari M, Konkimalla VB, Jaiswal A (2023) Quaternary pullulan-functionalized 2D MoS2 glycosheets: a potent bactericidal nanoplatform for efficient wound disinfection and healing. ACS Appl Mater Interfaces

    Google Scholar 

  • Samanta AP, Ali MS, Orasugh JT, Ghosh SK, Chattopadhyay D (2022) Crosslinked nanocollagen-cellulose nanofibrils reinforced electrospun polyvinyl alcohol/methylcellulose/polyethylene glycol bionanocomposites: study of material properties and sustained release of ketorolac tromethamine. Carbohydr Polym Technol Appl 3:100195

    CAS  Google Scholar 

  • Sharif S, Abbas G, Hanif M, Bernkop-Schnürch A, Jalil A, Yaqoob M (2019) Mucoadhesive micro-composites: chitosan coated halloysite nanotubes for sustained drug delivery. Colloids Surf B: Biointerfaces 184:110527

    Article  CAS  Google Scholar 

  • Shirjandi M, Haddadi-Asl V, Abdollahi E, Khanipour F (2022) Synthesis of pH-sensitive polydopamine capsules via pickering emulsions stabilized by cellulose nanocrystals to study drug release behavior. Polymer 255:125111

    Article  CAS  Google Scholar 

  • Singha I, Basu A (2022) Chitosan based injectable hydrogels for smart drug delivery applications. Sensors Int 3:100168

    Article  Google Scholar 

  • Tanwar A, Kalode P, Roshni V, Prema B, Doshi P, Ottoor D (2023) Influence of nanofillers (Ag NPs and C. dots) on the controlled drug release profile of gelatin-grafted-polyacrylamide hydrogel: an in vitro study. Mater Today Commun 35:105922

    Article  CAS  Google Scholar 

  • Vashist A, Sharif A (2013) Hydrogels: smart materials for drug delivery. Orient J Chem 29:861

    Article  Google Scholar 

  • Wang F, Huang K, Xu Z, Shi F, Chen C (2022) Self-healable nanocellulose composite hydrogels combining multiple dynamic bonds for drug delivery. Int J Biol Macromol 203:143–152

    Article  CAS  Google Scholar 

  • Warale D, Prabhu A, Kouser S, Shabeena M, Manasa D, Nagaraja G (2023) Incorporation of sodium alginate functionalized halloysite nanofillers into poly (vinyl alcohol) to study mechanical, cyto/heme compatibility and wound healing application. Int J Biol Macromol 232:123278

    Article  CAS  Google Scholar 

  • Yang M, Abdalkarim SYH, Yu H-Y, Asad RA, Ge D, Zhou Y (2023) Thermo-sensitive composite microspheres incorporating cellulose nanocrystals for regulated drug release kinetics. Carbohydr Polym 301:120350

    Article  CAS  Google Scholar 

  • Yin W, Nziengui Raby RB, Li Y, Li Z, Sun M, Huang Z (2023) An alternating magnetic field-controlled drug delivery system based on 4, 4′-Azobis (4-cyanovaleric acid)-functioned Fe3O4@ chitosan nanoparticles. Bioengineering 10:129

    Article  CAS  Google Scholar 

  • Yusefi M, Shameli K, Lee-Kiun MS, Teow S-Y, Moeini H, Ali RR, Kia P, JIE, C. J. & Abdullah, N. H. (2023) Chitosan coated magnetic cellulose nanowhisker as a drug delivery system for potential colorectal cancer treatment. Int J Biol Macromol 233:123388

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Materials and Metallurgical Engineering, Amirkabir University of Technology, Tehran, Iran

    Sepideh Amjad-Iranagh & Maryam Bendokht

Authors
  1. Sepideh Amjad-Iranagh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Maryam Bendokht
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sepideh Amjad-Iranagh .

Editor information

Editors and Affiliations

  1. Chemistry, Isfahan University of Technology, Isfahan, Iran

    Shadpour Mallakpour

  2. Chemistry and EVSC, New Jersey Institute of Technology, Newark, NJ, USA

    Chaudhery Mustansar Hussain

Rights and permissions

Reprints and permissions

Copyright information

© 2024 Springer Nature Singapore Pte Ltd.

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Amjad-Iranagh, S., Bendokht, M. (2024). Nanofillers in the Field of Drug Delivery System. In: Mallakpour, S., Hussain, C.M. (eds) Handbook of Nanofillers. Springer, Singapore. https://doi.org/10.1007/978-981-99-3516-1_82-1

Download citation

  • DOI: https://doi.org/10.1007/978-981-99-3516-1_82-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-99-3516-1

  • Online ISBN: 978-981-99-3516-1

  • eBook Packages: Springer Reference Chemistry and Mat. ScienceReference Module Physical and Materials ScienceReference Module Chemistry, Materials and Physics

Publish with us

Policies and ethics

Search

Navigation