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Innovation in Stabilization of Biopharmaceuticals

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Recent Advances in Pharmaceutical Innovation and Research

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Abstract

The applications of biopharmaceuticals, therapeutic molecules of biological origin, are increasing every day. The major reasons for this preference are target specificity and lower side effects. Production and downstream processing of biopharmaceuticals have their challenges that raise their final cost. The instability of proteins, during expression, purification, formulation, storage, and administration, is an issue that needs to be addressed if biopharmaceuticals are to achieve their full clinical potential. This requires a thorough understanding of the protein structure and changes that it undergoes when exposed to physical and chemical stressors. Changes in protein structure lead to a reduction in therapeutic efficacy but may introduce undesirable immunogenicity as well. A comprehensive appreciation of these changes will help devise rational usage of osmolytes as protein stabilizers. A novel direction in this is the use of nucleic aptamers that are capable of stabilizing proteins against a multitude of stress conditions. Changing/modifying pre-conceived notions of protein stabilizers is likely to yield long-lasting formulations.

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Authors and Affiliations

  1. Department of Biotechnology, National Institute of Pharmaceutical Education and Research, S.A.S. Nagar, Punjab, India

    Shivcharan Prasad & Ipsita Roy

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  1. Shivcharan Prasad
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  2. Ipsita Roy
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Correspondence to Ipsita Roy .

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  1. Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Mohali, India

    Prati Pal Singh

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Prasad, S., Roy, I. (2023). Innovation in Stabilization of Biopharmaceuticals. In: Singh, P.P. (eds) Recent Advances in Pharmaceutical Innovation and Research. Springer, Singapore. https://doi.org/10.1007/978-981-99-2302-1_1

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