Roles of Sustainable Biomaterials in Biomedical Engineering for Ischemic Stroke Therapy

Othman, Farah Amna; Satar, Asmaa’ Mohd; Tan, Suat Cheng

doi:10.1007/978-981-99-2267-3_19

Farah Amna Othman³,
Asmaa’ Mohd Satar³ &
Suat Cheng Tan³

203 Accesses

Abstracts

Ischemic stroke is the leading cause of adult disability which imposes high socio-economic burden worldwide. Natural and synthetic biomaterials have been elucidated as viable strategies for the treatment of ischemic stroke since decades. Nowadays, due to the advanced development in biomedical engineering, biomaterial applications have been perfected for sustainable usage in different phases of in vitro, in vivo and clinical studies. This chapter reviews a broad range of sustainable biomaterials and major therapeutic roles of sustainable biomaterials for ischemic stroke treatment. Furthermore, the neurological recovery effects triggered by these engineered biomaterials after being implanted into in vivo ischemic stroke models are highlighted as well. In brief, this chapter presents the roles and potentials of sustainable biomaterials in biomedical engineering for ischemic stroke therapy.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Chapter: USD 29.95; Price excludes VAT (USA)

eBook: USD 169.00; Price excludes VAT (USA)

Hardcover Book: USD 219.99; Price excludes VAT (USA)

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

ASP:: Spermine-modified amylose
ATP:: Adenosine triphosphate
BBB:: Blood brain barrier
BCSFB:: Blood-cerebrospinal-fluid barrier
bFGF:: Basic fibroblast growth factor
CAM:: Cell adhesion molecule
CDI:: 1,1′-carbonyldiimidazole
CNS:: Central nervous system
CS-maleimide:: Chitosan-maleimide
ECM:: Extracellular matrix
ECs:: Endothelial cells
FDA:: Food and Drug Administration
Fuco-SPs:: Fucoidan-functionalized dextran submicroparticles
GFP:: Green fluorescent protein
HA:: Hyaluronic acid
HUVECs:: Human umbilical vein endothelial cells
I/R:: Ischemia/reperfusion
IV:: Intravenous
LBD:: Laminin-binding domain
MC:: Methylcellulose
MCA:: Middle cerebral artery
MCAO:: Middle cerebral artery occlusion
MRI:: Magnetic resonance imaging
MSCs:: Mesenchymal stem cells
Ngn2:: Neurogenin-2
NSCs:: Neural stem cells
OD:: Optical density
OGD:: Oxygen glucose deprivation
PA:: Palmitic acid
PCNs:: Polyelectrolyte complex nanoparticles
PEG:: Polyethylene glycol
pH:: Potential hydrogen
PLA:: Poly lactic acid
PLGA:: Poly (lactic-co-glycolic acid)
PTD:: Protein transduction domain
ROS:: Reactive oxygen species
rtPA:: Recombinant tissue plasminogen activator
RUI:: Research University Individual
SDF-1α:: Stromal derived factor 1α
SPION:: Superparamagnetic iron oxide nanoparticles
SVZ:: Subventricular zone
TAT:: Transactivator of transcription

References

An SJ, Kim TJ, Yoon BW (2017) Epidemiology, risk factors, and clinical features of intracerebral hemorrhage: an update. J Stroke 19:3–10. PMID: 28178408. https://doi.org/10.5853/JOS.2016.00864
Article Google Scholar
Baker BM, Chen CS (2012) Deconstructing the third dimension: how 3D culture microenvironments alter cellular cues. J Cell Sci 125:3015–3024
Google Scholar
Balami JS, Sutherland BA, Buchan AM (2013) Complications associated with recombinant tissue plasminogen activator therapy for acute ischaemic stroke. CNS Neurol Disord Drug Targets 12:155–169. PMID: 23394532. https://doi.org/10.2174/18715273112119990050
Article Google Scholar
Boaro A, Ageitos L, Torres M, Bartoloni FH, de la Fuente-Nunez C (2020) Light-emitting probes for labeling peptides. Cell Rep Phys Sci 1(12):100257. https://doi.org/10.1016/j.xcrp.2020.100257
Article Google Scholar
Boncoraglio GB, Ranieri M, Bersano A, Parati EA, Del Giovane C (2019) Stem cell transplantation for ischemic stroke. Cochrane Database Syst Rev 5:CD007231
Google Scholar
Chen X, Wang K (2016) The fate of medications evaluated for ischemic stroke pharmacotherapy over the period 1995–2015. Acta Pharm Sin B 6:522. PMID: 27818918. https://doi.org/10.1016/J.APSB.2016.06.013
Article Google Scholar
Chen H, Ma Y, Hsu T, Chen J (2020) Preparation of peptide and recombinant tissue plasminogen activator conjugated poly (lactic-co-glycolic acid) (PLGA) magnetic nanoparticles for dual targeted thrombolytic therapy. Int J Mol Sci 21(8):2690
Article Google Scholar
Choi Y, Min SK, Usoltseva R, Silchenko A, Zvyagintseva T, Ermakova S, Kim JK (2018) Thrombolytic fucoidans inhibit the tPA-PAI1 complex, indicating activation of plasma tissue-type plasminogen activator is a mechanism of fucoidan-mediated thrombolysis in a mouse thrombosis model. Thromb Res 161:22–25. https://doi.org/10.1016/j.thromres.2017.11.015
Article Google Scholar
Cuartero MI, García-Culebras A, Torres-López C, Medina V, Fraga E, Vázquez-Reyes S, Jareño-Flores T, García-Segura JM, Lizasoain I, Moro MÁ (2021) Post-stroke neurogenesis: friend or foe? Front Cell Develop Biol 9:657846. PMID: 33834025. https://doi.org/10.3389/FCELL.2021.657846
Article Google Scholar
De Becker A, Van Riet I (2016) Homing and migration of mesenchymal stromal cells: how to improve the efficacy of cell therapy? World J Stem Cells 8:73–87. https://doi.org/10.4252/wjsc.v8.i3.73
Article Google Scholar
Decavel P, Vuillier F, Moulin T (2012) Lenticulostriate infarction. Front Neurol Neurosci 30:115–119. PMID: 22377876. https://doi.org/10.1159/000333606
Article Google Scholar
Deng B, Gou X, Chen H, Li L, Zhong H, Xu H, Jiang F, Zhao Z, Wang Q, Xu L (2013) Targeted delivery of Neurogenin-2 protein in the treatment for cerebral ischemia-reperfusion injury. Biomaterials 34:8786–8797. https://doi.org/10.1016/j.biomaterials.2013.07.076
Article Google Scholar
Duncan K, Gonzales-Portillo GS, Acosta SA, Kaneko Y, Borlongan CVTN (2015) Stem cell-paved biobridges facilitate stem transplant and host brain cell interactions for stroke therapy. Brain Res 1623:160–165
Article Google Scholar
Edwards DN, Bix GJ (2019) Roles of blood-brain barrier integrins and extracellular matrix in stroke. Am J Physiol Cell Physiol 316:C252–C263. PMID: 30462535. https://doi.org/10.1152/AJPCELL.00151.2018/ASSET/IMAGES/LARGE/ZH00011983690003.JPEG
Article Google Scholar
Feske SK (2021) Ischemic stroke. Am J Med 134:1457–1464. . PMID: 34454905. https://doi.org/10.1016/J.AMJMED.2021.07.027
Article Google Scholar
Gera A, Steinberg GK, Guzman R (2010) In vivo neural stem cell imaging: current modalities and future directions. Regen Med 5:73–86
Article Google Scholar
Ghuman H, Massensini AR, Donnelly J, Kim SM, Medberry CJ, Badylak SF, Modo M (2016) ECM hydrogel for the treatment of stroke: characterization of the host cell infiltrate. Biomaterials 91:166. PMID: 27031811. https://doi.org/10.1016/J.BIOMATERIALS.2016.03.014
Article Google Scholar
Ghuman H, Matta R, Tompkins A, Nitzsche F, Badylak SF, Gonzalez AL, Modo M (2021) ECM hydrogel improves the delivery of PEG microsphere-encapsulated neural stem cells and endothelial cells into tissue cavities caused by stroke. Brain Res Bull 168:120–137. https://doi.org/10.1016/j.brainresbull.2020.12.004
Article Google Scholar
Gore M, Bansal K, Asuncion RMD (2022) Lacunar stroke. StatPearls (e-pub ahead of print)
Google Scholar
Han Q, Li B, Feng H, Xiao Z, Chen B, Zhao Y, Huang J, Dai J (2011) The promotion of cerebral ischemia recovery in rats by laminin-binding BDNF. Biomaterials 32:5077–5085. PMID: 21529937. https://doi.org/10.1016/J.BIOMATERIALS.2011.03.072
Article Google Scholar
He Z, Ning N, Zhou Q, Khoshnam SE, Farzaneh M (2020) Mitochondria as a therapeutic target for ischemic stroke. Free Radic Biol Med 146:45–58. . PMID: 31704373. https://doi.org/10.1016/J.FREERADBIOMED.2019.11.005
Article Google Scholar
Hong KU, Li QH, Guo Y et al (2013) A highly sensitive and accurate method to quantify absolute numbers of c-kit+ cardiac stem cells following transplantation in mice. Basic Res Cardiol 108:346
Article Google Scholar
Hsu T, Lu Y, Lin Y, Huang Y, Hsieh L, Wu B, Lin Y, Chen L, Wang H, Chuang J, Fang Y, Huang C (2021) Transplantation of 3D MSC/HUVEC spheroids with neuroprotective and proangiogenic potentials ameliorates ischemic stroke brain injury. Biomaterials 272:120765. https://doi.org/10.1016/j.biomaterials.2021.120765
Article Google Scholar
Huang AB, Jiang X, Zhang T (2017) Peptide modified mesenchymal stem cells as targeting delivery system transfected with MiR-133b for the treatment of cerebral ischemia. Int J Pharm 531(1):90–100. https://doi.org/10.1016/j.ijpharm.2017.08.073
Article Google Scholar
Hughes RE, Tadi P, Bollu PC (2022) TPA therapy. StatPearls, pp 1–6. https://www.ncbi.nlm.nih.gov/books/NBK482376/. Accessed 11 September 2022
Google Scholar
Hwong WY, Ang SH, Bots ML, Sivasampu S, Selvarajah S, Law WC, Latif LA, Vaartjes I (2021) Trends of stroke incidence and 28-day all-cause mortality after a stroke in Malaysia: a linkage of national data sources. Global Heart 16:39. PMID: 34211825. https://doi.org/10.5334/GH.791
Article Google Scholar
Jian W, Wang H, Kuan C, Chen M, Wu H, Sun J, Wang T (2018) Glycosaminoglycan-based hybrid hydrogel encapsulated with polyelectrolyte complex nanoparticles for endogenous stem cell regulation in central nervous system regeneration. Biomaterials 174:17–30. https://doi.org/10.1016/j.biomaterials.2018.05.009
Article Google Scholar
Jilani TN, Siddiqui AH (2023) Tissue plasminogen activator. StatPearls, Treasure Island, FL
Google Scholar
Jin R, Yang G, Li G (2010) Inflammatory mechanims in ischemic stroke: role of inflammatory cells. J Leukoc Biol 87:779–789
Article Google Scholar
Jinatongthai P, Kongwatcharapong J, Foo CY, Phrommintikul A, Nathisuwan S, Thakkinstian A, Reid CM, Chaiyakunapruk N (2017) Comparative efficacy and safety of reperfusion therapy with fibrinolytic agents in patients with ST-segment elevation myocardial infarction: a systematic review and network meta-analysis. Lancet 390:747–759. PMID: 28831992 DOI: 10.1016/S0140-6736(17)31441-1
Article Google Scholar
Juenet M, Aid-Launais R, Li B, Berger A, Aerts J, Ollivier V, Nicoletti A, Letourneur D, Chauvierre C (2018) Thrombolytic therapy based on fucoidan-functionalized polymer nanoparticles targeting P-selectin. Biomaterials 156:204–216. https://doi.org/10.1016/j.biomaterials.2017.11.047
Article Google Scholar
Kapałczyńska M, Kolenda T, Przybyła W, Zajączkowska M, Teresiak A, Filas V, Ibbs M, Bliźniak R, Łuczewski Ł, Lamperska K (2018) 2D and 3D cell cultures – a comparison of different types of cancer cell cultures. Arch Med Sci 14:910. PMID: 30002710. https://doi.org/10.5114/AOMS.2016.63743
Article Google Scholar
Kim H, Bae C, Kook Y, Koh WG, Lee K, Park MH (2019) Mesenchymal stem cell 3D encapsulation technologies for biomimetic microenvironment in tissue regeneration. Stem Cell Res Ther 10:51
Article Google Scholar
Lankalapalli S, Kolapalli VRM (2009) Polyelectrolyte complexes: a review of their applicability in drug delivery technology. Indian J Pharm Sci 71:481. PMID: 20502564. https://doi.org/10.4103/0250-474X.58165
Article Google Scholar
Leslie SK, Kinney RC, Schwartz Z, Boyan BD (2017) Microencapsulation of stem cells for therapy. Methods Mol Biol 1479:251–259
Article Google Scholar
Lin B, Zhang J, Lu L, Mao J, Cao M (2017) Superparamagnetic iron oxide nanoparticles-complexed cationic amylose for in vivo magnetic resonance imaging tracking of transplanted stem cells in stroke. Nanomaterials (Basel) 7(5):107. https://doi.org/10.3390/nano7050107
Article Google Scholar
Liu F, Lu J, Manaenko A, Tang J, Hu Q (2018) Mitochondria in ischemic stroke: new insight and implications. Aging Dis 9:924. PMID: 30271667. https://doi.org/10.14336/AD.2017.1126
Article Google Scholar
Long KR, Huttner WB (2022) The role of the extracellular matrix in neural progenitor cell proliferation and cortical folding during human neocortex development. Front Cell Neurosci 15:563. https://doi.org/10.3389/FNCEL.2021.804649/BIBTEX
Article Google Scholar
Lotze J, Reinhardt U, Seitz O, Beck-Sickinger AG (2016) Peptide-tags for site-specific protein labelling in vitro and in vivo. Mol BioSyst 12:1731–1745. PMID: 26960991. https://doi.org/10.1039/C6MB00023A
Article Google Scholar
Ma YH, Liu CH, Liang Y, Chen JP, Wu T (2019) Targeted delivery of plasminogen activators for thrombolytic therapy: an integrative evaluation. Molecules 24(18):3407. PMID: 31546842. https://doi.org/10.3390/MOLECULES24183407
Article Google Scholar
Makadia HK, Siegel SJ (2011) Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier. Polymers 3:1377. PMID: 22577513. https://doi.org/10.3390/POLYM3031377
Article Google Scholar
Matsumoto M, Udomsinprasert W, Laengee P, Honsawek S, Patarakul K, Chirachanchai S (2016) A water-based chitosan-maleimide precursor for bioconjugation: an example of a rapid pathway for an in situ injectable adhesive gel. Macromol Rapid Commun 37:1618–1622. PMID: 27461078. https://doi.org/10.1002/MARC.201600257
Article Google Scholar
Min J, Farooq MU, Gorelick PB (2013) Neuroprotective agents in ischemic stroke: past failures and future opportunities. Clin Invest 3:1167–1177. https://doi.org/10.4155/cli.13.91
Article Google Scholar
Montaño A, Hanley DF, Hemphill JC (2021) Hemorrhagic stroke. Handb Clin Neurol 176:229–248. PMID: 33272397. https://doi.org/10.1016/B978-0-444-64034-5.00019-5
Article Google Scholar
Moore VDG, Payne RM (2004) Transactivator of transcription fusion protein transduction causes membrane inversion. J Biol Chem 279:32541–32544. PMID: 15169776. https://doi.org/10.1074/JBC.M405930200
Article Google Scholar
Nagpal A, Choy FC, Howell S, Hillier S, Chan F, Hamilton-Bruce MA, Koblar SA (2017) Safety and effectiveness of stem cell therapies in early-phase clinical trials in stroke: a systematic review and meta-analysis. Stem Cell Res Ther 8:191
Article Google Scholar
Olié V, Grave C, Tuppin P, Duloquin G, Béjot Y, Gabet A (2022) Patients hospitalized for ischemic stroke and intracerebral hemorrhage in France: time trends (2008–2019), in-Hospital Outcomes, Age and Sex Differences. J Clin Med 11:1669. https://doi.org/10.3390/jcm11061669
Article Google Scholar
Ouyang Q, Li F, Xie Y, Han J, Zhang Z, Feng Z, Su D, Zou X, Cai Y, Zou Y, Tang Y, Jiang X (2019) Meta-analysis of the safety and efficacy of stem cell therapies for ischemic stroke in preclinical and clinical studies. Stem Cells Dev 28:497–514
Article Google Scholar
Persidsky Y, Ramirez SH, Haorah J, Kanmogne GD (2006) Blood-brain barrier: structural components and function under physiologic and pathologic conditions. J Neuroimmune Pharmacol 1:223–236. PMID: 18040800. https://doi.org/10.1007/s11481-006-9025-3
Article Google Scholar
Reed M, Kerndt CC, Nicolas D (2022) Alteplase. In: xPharm: the comprehensive pharmacology reference, pp 1–5. PMID: 29763152. https://doi.org/10.1016/B978-008055232-3.61202-4
Chapter Google Scholar
Reiter RJ, Rosales-Corral S, Tan DX, Jou MJ, Galano A, Xu B (2017) Melatonin as a mitochondria-targeted antioxidant: one of evolution’s best ideas. Cell Mol Life Sci 74:3863–3881. https://doi.org/10.1007/s00018-017-2609-7
Article Google Scholar
Rhim T, Lee DY, Lee M (2013) Drug delivery systems for the treatment of ischemic stroke. Pharm Res 30:2429–2444. PMID: 23307348. https://doi.org/10.1007/s11095-012-0959-2
Article Google Scholar
Sadanandan N, Cozene B, Cho J, Park YJ, Saft M, Gonzales-portillo B, Borlongan CV (2020) Melatonin—a potent therapeutic for stroke and stroke-related dementia. Antioxidants 9:1–15
Article Google Scholar
Singh MN, Hemant KSY, Ram M, Shivakumar HG (2010) Microencapsulation: a promising technique for controlled drug delivery. Res Pharm Sci 5:65–77
Google Scholar
Suh SW, Shin BS, Ma H, Van Hoecke M, Brennan AM, Yenari MA, Swanson RA (2008) Glucose and NADPH oxidase drive neuronal superoxide formation in stroke. Ann Neurol 64:654–663
Article Google Scholar
Tan KS, Venketasubramanian N (2022) Stroke burden in Malaysia. Cerebrovasc Dis Extra 12:58. PMID: 35325896. https://doi.org/10.1159/000524271
Article Google Scholar
Tan DX, Manchester LC, Qin L, Reiter RJ (2016) Melatonin: a mitochondrial targeting molecule involving mitochondrial protection and dynamics. Int J Mol Sci 17:2124. https://doi.org/10.3390/ijms17122124
Article Google Scholar
Tang J-N, Cores J, Huang K, Cui XL, Luo L, Zhang JY, Li TS, Qian L, Cheng K (2018) Concise review: is cardiac cell therapy dead? Embarrassing trial outcomes and new directions for the future. Stem Cells Transl Med 7:354–359. https://doi.org/10.1002/sctm.17-0196
Article Google Scholar
Wang J, Fields J, Zhao C, Langer J, Thimmulappa RK, Kensler TW, Yamamoto M, Biswal S, Doré S (2007) Role of Nrf2 in protection against intracerebral hemorrhage injury in mice. Free Radic Biol Med 43:408–414
Article Google Scholar
Wang X, He J, Wang Y, Cui F-Z (2012) Hyaluronic acid-based scaffod for central neural tissue engineering. Interf Focus 2:278–291
Article Google Scholar
Wang Y, Xing M, Cao Q, Ji A, Liang H, Song S (2019) Biological activities of Fucoidan and the factors mediating its therapeutic effects: a review of recent studies. Mar Drugs 17(3):183. PMID: 30897733. https://doi.org/10.3390/MD17030183
Article Google Scholar
Woodruff TM, Thundyil J, Tang S-C, Sobey CG, Taylor SM, Arumugam TV (2011) Pathophysiology, treatment, and animal and cellular models of human ischemic stroke. Mol Neurodegener 6:11
Article Google Scholar
Wu D, Liu J, Pang X, Wang S, Zhao J, Zhang X, Feng L (2014) Palmitic acid exerts pro-inflammatory effects on vascular smooth muscle cells by inducing the expression of C-reactive protein, inducible nitric oxide synthase and tumor necrosis factor-α. Int J Mol Med 34:1706–1712. PMID: 25242580. https://doi.org/10.3892/IJMM.2014.1942/HTML
Article Google Scholar
Yip H, Kumar N, Lin K, Sung P (2021) Melatonin rescues cerebral ischemic events through upregulated tunneling nanotube-mediated mitochondrial transfer and downregulated mitochondrial oxidative stress in rat brain. Biomed Pharmacother 139:111593. https://doi.org/10.1016/j.biopha.2021.111593
Article Google Scholar
Zenych A, Jacqmarcq C, Aid R, Fournier L, Forero Ramirez LM, Chaubet F, Bonnard T, Vivien D, Letourneur D, Chauvierre C (2021) Fucoidan-functionalized polysaccharide submicroparticles loaded with alteplase for efficient targeted thrombolytic therapy. Biomaterials 277:121102. https://doi.org/10.1016/j.biomaterials.2021.121102
Article Google Scholar
Zhang S, Zhou Y, Li R, Chen Z, Fan X (2022) Advanced drug delivery system against ischemic stroke. J Control Release 344:173–201
Article Google Scholar
Zhao X, Li Q, Guo Z, Li Z (2021) Constructing a cell microenvironment with biomaterial scaffolds for stem cell therapy. Stem Cell Res Ther 12:583. https://doi.org/10.1186/s13287-021-02650-w
Article Google Scholar

Download references

Acknowledgement

This work was supported by Universiti Sains Malaysia (USM) Research University Individual (RUI) Grant, No: 1001/PPSK/8012273. All authors thank the Universiti Sains Malaysia libraries, particularly Perpustakaan Hamdan Tahir and Perpustakaan Hamzah Sendut, for providing the resources to write this book chapter. The authors also appreciate all the scientists whose previous work contributed to this review article.

Author information

Authors and Affiliations

School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
Farah Amna Othman, Asmaa’ Mohd Satar & Suat Cheng Tan

Authors

Farah Amna Othman
View author publications
You can also search for this author in PubMed Google Scholar
Asmaa’ Mohd Satar
View author publications
You can also search for this author in PubMed Google Scholar
Suat Cheng Tan
View author publications
You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Suat Cheng Tan .

Editor information

Editors and Affiliations

Department of Biomedical Engineering, Faculty of Engineering, Universiti Malaya, Kuala Lumpur, Malaysia
Wan Safwani Wan Kamarul Zaman
Biomedicine Programme, School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia
Nurul asma Abdullah

Ethics declarations

All authors declare no conflict of interest.

Rights and permissions

Reprints and permissions

Copyright information

About this chapter

Cite this chapter

Othman, F.A., Satar, A.M., Tan, S.C. (2023). Roles of Sustainable Biomaterials in Biomedical Engineering for Ischemic Stroke Therapy. In: Wan Kamarul Zaman, W.S., Abdullah, N.a. (eds) Sustainable Material for Biomedical Engineering Application. Springer, Singapore. https://doi.org/10.1007/978-981-99-2267-3_19

Download citation

DOI: https://doi.org/10.1007/978-981-99-2267-3_19
Published: 02 August 2023
Publisher Name: Springer, Singapore
Print ISBN: 978-981-99-2266-6
Online ISBN: 978-981-99-2267-3
eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics