Skip to main content
SpringerLink
Log in

Histone Chaperones in Cancer

  • Living reference work entry
  • Latest version View entry history
  • First Online:
Handbook of Oncobiology: From Basic to Clinical Sciences

Abstract

Histone epigenetics has three layers including histone modifications, histone variants, and histone chaperones. Unlike the first two components, limited information on histone chaperones in diseases is available. However, with recent technological advances, these fundamental molecules are gradually rising above to demonstrate their role in diseases like cancer. In this chapter, we will focus on different types of histone chaperones that are associated with cancers of different histological origins, their broad mechanistic pathway of regulation, and finally their usage in therapeutics. Similar to the nature of cancer, most of the histone chaperones are multifunctional. In addition to histone metabolism, they regulate DNA repair, replication, transcription, and other biological phenomena. The contribution of histone chaperones in cancer is resourced from their mutation, chromosomal translocation, and altered level in comparison to normal healthy individual. Unlike the histone-modifying enzymes, the potential of histone chaperones is yet to be exploited in therapeutics. It is always a better idea to design targets which can be modulated without infusing any change at the genomic level; hence exploiting the components of histone epigenetics in this context would be highly favorable for future medicines.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References

  • Angelov D, Bondarenko VA, Almagro S, Menoni H, Mongélard F, Hans MF, Studitsky VM, Hamiche A, Dimitrov S, Bouvet P (2006) Nucleolin is a histone chaperone with FACT-like activity and assists remodeling of nucleosomes. EMBO J 25:1669–1679

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Attwood K, Fleyshman D, Prendergast L, Paszkiewicz G, Omilian AR, Bshara W, Gurova K (2017) Prognostic value of histone chaperone FACT subunits expression in breast cancer. Breast Cancer 9:301–311

    CAS  PubMed  PubMed Central  Google Scholar 

  • Audia JE, Campbell RM (2016) Histone modifications and cancer. Cold Spring Harb Perspect Biol 8:a019521

    Article  PubMed  PubMed Central  Google Scholar 

  • Aydin MA, Gul G, Kiziltan R, Algul S Kemik (2020) Nucleosome assembly protein 1-like 1 (NAP1L1) in colon cancer patients: a potential biomarker with diagnostic and prognostic utility. Eur Rev Med Pharmacol Sci 24:10512–10517

    Google Scholar 

  • Barzilova VD, Drury J, Rogers B, Thomas E, Ahmed F, Bradfield A, Al-Lamee H, Hapangama DK (2022) Role of nucleolin in endometrial precancerous hyperplasia and carcinogenesis ex vivo and in silico study. Int J Mol Sci 23:6228

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Baylin SB, Jones PA (2016) Epigenetic determinants of cancer. Cold Spring Harb Perspect Biol 8:a019505

    Article  PubMed  PubMed Central  Google Scholar 

  • Benitez JA, Ma J, D’Antonio M, Boyer A, Camargo MF, Zanca C, Kelly S, Khodadadi-Jamayran A, Jameson NM, Andersen M, Miletic H, Saberi S, Frazer KA, Cavenee WK, Furnari FB (2017) PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3. Nat Comm 8:15223

    Google Scholar 

  • Bi L, Xie C, Yao M, Thae SS, Vignarajan S, Wang Y, Wang Q, Xi Z, Xu H, Li Z, De Souza P, Tee A, Wong M, Liu T, Zhao X, Zhou J, Xu L, Dong Q (2019) The histone chaperone complex FACT promotes proliferative switch of G(0) cancer cells. Int J Cancer 145:164–178

    Article  CAS  PubMed  Google Scholar 

  • Carrion A, Ingelmo-Torres M, Lozano JJ, Montalbo R, D’Anna M, Mercader C, Velez E, Ribal MJ, Alcaraz A, Mengual L (2021) Prognostic classifier for predicting biochemical recurrence in localized prostate cancer patients after radical prostatectomy. Urol Oncol 39:493.e17–493.e25

    Article  PubMed  Google Scholar 

  • Carter DR, Murray J, Cheung BB, Gamble L, Koach J, Tsang J, Sutton S, Kalla H, Syed S, Gifford A J, Issaeva N, Biktasova A, Atmadibrata B, Sun Y, Sokolowski N, Ling D, Kim P Y, Webber H, Clark A, Ruhle M, Liu B, Oberthuer A, Fischer M, Byrne J, Saletta F, Thwe le M, Purmal A, Haderski G, Burkhart C, Speleman F, De Preter K, Beckers A, Ziegler D S, Liu T, Gurova KV, Gudkov AV, Norris MD, Haber M, Marshall GM (2015) Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma. Sci Transl Med 7:312ra176

    Google Scholar 

  • Chang HW, Nizovtseva EV, Razin SV, Formosa T, Gurova KV, Studitsky VM (2019) Histone Chaperone FACT and Curaxins Effects on genome structure and function. J Cancer Metastasis Treat 5:78

    CAS  PubMed  PubMed Central  Google Scholar 

  • Chen Y, Hu J (2020) Nucleophosmin1 (NPM1) abnormality in hematologic malignancies, and therapeutic targeting of mutant NPM1 in acute myeloid leukemia. Ther Adv Hematol 11:2040620719899818

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chen YF, Liang YX, Yang JA, Yuan DZ, Li J, Zheng SS, Wan YP, Wang B, Han ZD, Zhong WD (2019a) Upregulation of Holliday junction recognition protein predicts poor prognosis and biochemical recurrence in patients with prostate cancer. Oncol Lett 18:6697–6703.

    Google Scholar 

  • Chen T, Zhou L, Zhou Y, Zhou W, Huang H, Yin S, Xie H, Zhou L, Zheng S (2019b) HJURP promotes epithelial-to-mesenchymal transition via upregulating SPHK1 in hepatocellular carcinoma. Int J Biol Sci 15:1139–1147

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chen C, Sun MA, Warzecha C, Bachu M, Dey A, Wu T, Adams PD, Macfarlan T, Love P, Ozato K (2020) HIRA, a diGeorge syndrome candidate gene, confers proper chromatin accessibility on HSCs and supports all stages of hematopoiesisx. Cell Rep 30:2136–2149.e2134

    Google Scholar 

  • Corbeski I, Guo X, Eckhardt BV, Fasci D, Wiegant W, Graewert MA, Vreeken K, Wienk H, Svergun DI, Heck A, van Attikum H, Boelens R, Sixma TK, Mattiroli F, van Ingen H (2022) Chaperoning of the histone octamer by the acidic domain of DNA repair factor APLF. Sci Adv 8:eabo0517

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Corpet A, De Koning L, Toedling J, Savignoni A, Berger F, Lemaître C, O'Sullivan RJ, Karlseder J, Barillot E, Asselain B, Sastre-Garau X, Almouzni G (2011) Asf1b, the necessary Asf1 isoform for proliferation, is predictive of outcome in breast cancer. EMBO J 30:480–493

    Article  CAS  PubMed  Google Scholar 

  • Davidson B, McFadden E, Holth A, Brunetti M, Flørenes VA (2020) Death domain-associated protein (DAXX) expression is associated with poor survival in metastatic high-grade serous carcinoma. Virchows Arch 477:857–864

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • De Albuquerque Oliveira AC, Kappes F, Martins D, de Lima Filho JL (2018) The unique DEK oncoprotein in women's health: a potential novel biomarker. Biomed Pharmacother 106:142–148

    Article  PubMed  Google Scholar 

  • de Oca RM, Gurard-Levin ZA, Berger F, Rehman H, Martel E, Corpet A, de Koning L, Vassias I, Wilson LO, Meseure D, Reyal F, Savignoni A, Asselain B, Sastre-Garau X, Almouzni G (2015) The histone chaperone HJURP is a new independent prognostic marker for luminal A breast carcinoma. Mol Oncol 9:657–674

    Article  Google Scholar 

  • Dong W, Li L, Teng X, Yang X, Si S, Chai J (2020) End processing factor APLF promotes NHEJ efficiency and contributes to TMZ- and ionizing radiation-resistance in glioblastoma cells. Onco Targets Ther 13:10593–10605

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Drané P, Ouararhni K, Depaux A, Shuaib M, Hamiche A (2010) The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3. Genes Dev 24:1253–1265

    Article  PubMed  PubMed Central  Google Scholar 

  • Feng Z, Zhang J, Zheng Y, Wang Q, Min X, Tian T (2021) Elevated expression of ASF1B correlates with poor prognosis in human lung adenocarcinoma. Per Med 18:115–127

    Article  PubMed  Google Scholar 

  • Firlej V, Soyeux P, Nourieh M, Huet E, Semprez F, Allory Y, Londono-Vallejo A, De La Taille A, Vacherot F, Destouches D (2022) Overexpression of nucleolin and associated genes in prostate cancer. Int J Mol Sci 23:4491

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Garcia H, Miecznikowski JC, Safina A, Commane M, Ruusulehto A, Kilpinen S, Leach RW, Attwood K, Li Y, Degan S, Omilian AR, Guryanova O, Papantonopoulou O, Wang J, Buck M, Liu S, Morrison C, Gurova KV (2013) Facilitates chromatin transcription complex is an “accelerator” of tumor transformation and potential marker and target of aggressive cancers. Cell Rep 4:159–173

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gasparian AV, Burkhart CA, Purmal AA, Brodsky L, Pal M, Saranadasa M, Bosykh DA, Commane M, Guryanova OA, Pal S, Safina A, Sviridov S, Koman IE, Veith J, Komar AA, Gudkov AV, Gurova KV (2011) Curaxins: anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACT. Sci Transl Med 3:95ra74

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gomes AP, Ilter D, Low V, Rosenzweig A, Shen ZJ, Schild T, Rivas MA, Er EE, McNally DR, Mutvei AP, Han J, Ou YH, Cavaliere P, Mullarky E, Nagiec M, Shin S, Yoon SO, Dephoure N, Massagué J, Melnick AM, Cantley LC, Tyler JK, Blenis J (2019) Dynamic incorporation of histone H3 variants into chromatin is essential for acquisition of aggressive traits and metastatic colonization. Cancer Cell 36:402–417e413

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gurova K, Chang HW, Valieva ME, Sandlesh P, Studitsky VM (2018) Structure and function of the histone chaperone FACT - resolving FACTual issues. Biochim Biophys Acta Gene Regul Mech. S1874-9399:30159-7

    Google Scholar 

  • Hall C, Nelson DM, Ye X, Baker K, DeCaprio JA, Seeholzer S, Lipinski M, Adams PD (2001) HIRA, the human homologue of yeast Hir1p and Hir2p is a novel cyclin-cdk2 substrate whose expression blocks S-phase progression. Mol Cell Biol 21:1854–1865

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hammond CM, Strømme CB, Huang H, Patel DJ, Groth A (2017) Histone chaperone networks shaping chromatin function. Nat Rev Mol Cell Biol 18:141–158

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hanahan D (2022) Hallmarks of cancer: new dimensions. Cancer Discov 12:31–46

    Article  CAS  PubMed  Google Scholar 

  • Hoang SM, Kaminski N, Bhargava R, Barroso-González J, Lynskey ML, García-Expósito L, Roncaioli JL, Wondisford AR, Wallace CT, Watkins SC, James DI, Waddell ID, Ogilvie D, Smith KM, da Veiga LF, Mellacharevu D, Nesvizhskii AI, Li J, Ray-Gallet D, Sobol RW, O'Sullivan RJ (2020) Regulation of ALT-associated homology-directed repair by polyADP-ribosylation. Nat Struct Mol Biol 27:1152–1164

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Holmberg Olausson K, Elsir T, Moazemi Goudarzi K, Nistér M, Lindström MS (2015) NPM1 histone chaperone is upregulated in glioblastoma to promote cell survival and maintain nucleolar shape. Sci Rep 5:16495

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hu Z, Huang G, Sadanandam A, Gu S, Lenburg ME, Pai M, Bayani N, Blakely EA, Gray JW, Mao JH (2010) The expression level of HJURP has an independent prognostic impact and predicts the sensitivity to radiotherapy in breast cancer. Breast Cancer Res 12:R18

    Article  PubMed  PubMed Central  Google Scholar 

  • Huang X, Liu J, Ma Q (2020) Prohibitin participates in the HIRA complex to promote cell metastasis in breast cancer cell lines. FEBS Open Bio 10:2182–2190

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hupfer A, Brichkina A, Adhikary T, Lauth M (2021) The mammalian Hedgehog pathway is modulated by ANP32 proteins. Biochem Biophys Res Commun 553:78–84

    Article  CAS  PubMed  Google Scholar 

  • Kang DH, Woo J, Kim H, Kim SY, Ji S, Jaygal G, Ahn TS, Kim HJ, Kwak HJ, Kim CJ, Baek MJ, Jeong D (2020) Prognostic relevance of HJURP expression in patients with surgically resected colorectal cancer. Int J Mol Sci 21:7928

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kappes F, Waldmann T, Mathew V, Yu J, Zhang L, Khodadoust MS, Chinnaiyan AM, Luger K, Erhardt S, Schneider R, Markovitz DM (2011) The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity. Genes Dev 25:673–678

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Karimi Dermani F, Gholamzadeh Khoei S, Afshar S, Amini R (2021) The potential role of nucleophosmin (NPM1) in the development of cancer. J Cell Physiol 236:7832–7852

    Article  CAS  PubMed  Google Scholar 

  • Kidd M, Modlin IM, Mane SM, Camp RL, Eick G, Latich I (2006) The role of genetic markers-NAP1L1, MAGE-D2, and MTA1-in defining small-intestinal carcinoid neoplasia. Ann Surg Oncol 13:253–262

    Article  PubMed  Google Scholar 

  • Kim JH, Youn Y, Lee JC, Kim J, Ryu JK, Hwang JH (2022) Downregulation of ASF1B inhibits tumor progression and enhances efficacy of cisplatin in pancreatic cancer. Cancer Biomark 34:647–659

    Article  CAS  PubMed  Google Scholar 

  • Le Y, Kan A, Li QJ, He MK, Chen HL, Shi M (2019) NAP1L1 is a prognostic biomarker and contribute to doxorubicin chemotherapy resistance in human hepatocellular carcinoma. Cancer Cell Int 19:228

    Article  PubMed  PubMed Central  Google Scholar 

  • Levidou G, Palamaris K, Sykaras AG, Andreadakis G, Masaoutis C, Theochari I, Korkolopoulou P, Rontogianni D, Theocharis S (2022) Unraveling the role of histone variant CENP-A and chaperone HJURP expression in thymic epithelial neoplasms. Int J Mol Sci 23:8339

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Liang X, Yuan X, Yu J, Wu Y, Li K, Sun C, Li S, Shen L, Kong F, Jia J, Björkholm M, Xu D (2017) Histone chaperone ASF1A predicts poor outcomes for patients with gastrointestinal cancer and drives cancer progression by stimulating transcription of β-catenin target genes. EBioMedicine 21:104–116

    Article  PubMed  PubMed Central  Google Scholar 

  • Liu X, Song J, Zhang Y, Wang H, Sun H, Feng X, Hou M, Chen G, Tang Q, Ji M (2020) ASF1B promotes cervical cancer progression through stabilization of CDK9. Cell Death Dis 11:705

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Liu Y, Li X, Zhang Y, Tang Y, Fang W, Liu X, Liu Z (2021) NAP1L1 targeting suppresses the proliferation of nasopharyngeal carcinoma. Biomed Pharmacother 143:112096

    Article  CAS  PubMed  Google Scholar 

  • Ma YS, Yang X, Liu Y, Ding H, Wu J, Shi Y, Jia CY, Lu G, Zhang D, Wang HM, Wang P, Yu F, Lv Z, Wang G, Liu J, Fu D (2021) Long non-coding RNA NORAD promotes pancreatic cancer stem cell proliferation and self-renewal by blocking microRNA-202-5p-mediated ANP32E inhibition. J Transl Med 19:400

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Majumder A, Syed KM, Mukherjee A, Lankadasari MB, Azeez JM, Sreeja S, Harikumar KB, Pillai MR, Dutta D (2018) Enhanced expression of histone chaperone APLF associate with breast cancer. Mol Cancer 17:76

    Article  PubMed  PubMed Central  Google Scholar 

  • Majumder A, Dharan AT, Baral I, Varghese PC, Mukherjee A, Subhadradevi L, Narayanan G, Dutta D (2019) Histone chaperone HIRA dictate proliferation vs differentiation of chronic myeloid leukemia cells. FASEB BioAdv 1:525–537

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mao M, Jia Y, Chen Y, Yang J, Xu L, Zhang X, Zhou J, Li Z, Chen C, Ju S, Wang L (2022) HJURP regulates cell proliferation and chemo-resistance via YAP1/NDRG1 transcriptional axis in triple-negative breast cancer. Cell Death Dis 13:396

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mascolo M, Travaglino A, Varricchio S, Russo D, Sabattini E, Agostinelli C, Bertuzzi C, Baldo A, Pileri A, Picardi M, Pane F, Staibano S (2021) Role of chromatin assembly factor-1/p60 and poly [ADP-ribose] polymerase 1 in mycosis fungoides. Virchows Arch 478:961–968

    Article  CAS  PubMed  Google Scholar 

  • Mehrotra PV, Ahel D, Ryan DP, Weston R, Wiechens N, Kraehenbuehl R, Owen-Hughes T, Ahel I (2011) DNA repair factor APLF is a histone chaperone. Mol Cell 41:46–55

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mohammad F, Helin K (2017) Oncohistones: drivers of pediatric cancers. Genes Dev 31:2313–2324

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Murphy KE, Meng FW, Makowski CE, Murphy PJ (2020) Genome-wide chromatin accessibility is restricted by ANP32E. Nat Commun 11:5063

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nagashio R, Kuchitsu Y, Igawa S, Kusuhara S, Naoki K, Satoh Y, Ichinoe M, Murakumo Y, Saegusa M, Sato Y (2020) Prognostic significance of NAP1L1 expression in patients with early lung adenocarcinoma. Biomed Res 41:149–159

    Article  CAS  PubMed  Google Scholar 

  • Nandy D, Rajam SM, Dutta D (2020) A three layered histone epigenetics in breast cancer metastasis. Cell Biosci 10:52

    Google Scholar 

  • Pease NA, Shephard MS, Sertorio M, Waltz SE, Vinnedge L (2020) DEK expression in breast cancer cells leads to the alternative activation of tumor associated macrophages. Cancers 12:1936

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rai TS, Cole JJ, Nelson DM, Dikovskaya D, Faller WJ, Vizioli MG, Hewitt RN, Anannya O, McBryan T, Manoharan I, van Tuyn J, Morrice N, Pchelintsev NA, Ivanov A, Brock C, Drotar ME, Nixon C, Clark W, Sansom OJ, Anderson KI, King A, Blyth K, Adams PD (2014) HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia. Genes Dev 28:2712–2725

    Article  PubMed  PubMed Central  Google Scholar 

  • Ray-Gallet D, Almouzni G (2022) H3-H4 histone chaperones and cancer. Curr Opin Genet Dev 73:101900

    Article  CAS  PubMed  Google Scholar 

  • Ray-Gallet D, Quivy JP, Scamps C, Martini EM, Lipinski M, Almouzni G (2002) HIRA is critical for a nucleosome assembly pathway independent of DNA synthesis. Mol Cell 9:1091–1100

    Article  CAS  PubMed  Google Scholar 

  • Reddy D, Bhattacharya S, Shah S, Rashid M, Gupta S (2022) DNA methylation mediated downregulation of histone H3 variant H3.3 affects cell proliferation contributing to the development of HCC. Biochim Biophys Acta Mol Basis Dis 1868:166284

    Article  CAS  PubMed  Google Scholar 

  • Richter C, Marquardt S, Li F, Spitschak A, Murr N, Edelhäuser BAH, Iliakis G, Pützer BM, Logotheti S (2019) Rewiring E2F1 with classical NHEJ via APLF suppression promotes bladder cancer invasiveness. J Exp Clin Cancer Res 38:292

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ruff GL, Murphy KE, Smith ZR, Vertino PM, Murphy PJ (2021) Subtype-independent ANP32E reduction during breast cancer progression in accordance with chromatin relaxation. BMC Cancer 21:1342

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sawatsubashi S, Murata T, Lim J, Fujiki R, Ito S, Suzuki E, Tanabe M, Zhao Y, Kimura S, Fujiyama S, Ueda T, Umetsu D, Ito T, Takeyama K, Kato S (2010) A histone chaperone, DEK, transcriptionally coactivates a nuclear receptor. Genes Dev 24:159–170

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schimmack S, Taylor A, Lawrence B, Alaimo D, Schmitz-Winnenthal H, Büchler MW, Modlin IM, Kidd M (2014) A mechanistic role for the chromatin modulator, NAP1L1, in pancreatic neuroendocrine neoplasm proliferation and metastases. Epigenetics Chromatin 7:15

    Article  PubMed  PubMed Central  Google Scholar 

  • Senapati P, Bhattacharya A, Das S, Dey S, Sudarshan D, Vishwakarma J, Sudevan S, Ramachandran R, Maliekal TT, Kundu TK (2022) Histone chaperone nucleophosmin regulates transcription of Key genes involved in oral tumorigenesis. Mol Cell Biol 42:e0066920

    Article  PubMed  Google Scholar 

  • Serafim RB, Cardoso C, Di Cristofaro LFM, Pienna Soares C, Araújo Silva W Jr, Espreafico EM, Paçó-Larson ML, Price BD, Valente V (2020) HJURP knockdown disrupts clonogenic capacity and increases radiation-induced cell death of glioblastoma cells. Cancer Gene Ther 27:319–329

    Article  CAS  PubMed  Google Scholar 

  • Shandilya J, Swaminathan V, Gadad SS, Choudhari R, Kodaganur GS, Kundu TK (2009) Acetylated NPM1 localizes in the nucleoplasm and regulates transcriptional activation of genes implicated in oral cancer manifestation. Mol Cell Biol 29:5115–5127

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shen J, Chen M, Lee D, Law CT, Wei L, Tsang FH, Chin DW, Cheng CL, Lee JM, Ng IO, Wong CC, Wong CM (2020) Histone chaperone FACT complex mediates oxidative stress response to promote liver cancer progression. Gut 69:329–342

    Article  CAS  PubMed  Google Scholar 

  • Shi X, Xu X, Shi N, Chen Y, Fu M (2021) MicroRNA-520d-3p suppresses melanoma cells proliferation by inhibiting the anti-silencing function 1B histone chaperone. Bioengineered 12:10703–10715

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Song H, Zeng J, Roychoudhury S, Biswas P, Mohapatra B, Ray S, Dowlatshahi K, Wang J, Band V, Talmon G, Bhakat KK (2020) Targeting histone chaperone FACT complex overcomes 5-fluorouracil resistance in colon cancer. Mol Cancer Ther 19:258–269

    Article  CAS  PubMed  Google Scholar 

  • Song H, Zeng J, Lele S, LaGrange CA, Bhakat KK (2021) APE1 and SSRP1 is overexpressed in muscle invasive bladder cancer and associated with poor survival. Heliyon 7:e06756

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sykaras AG, Pergaris A, Theocharis S (2021) Challenging, accurate and feasible: CAF-1 as a tumour proliferation marker of diagnostic and prognostic value. Cancers (Basel) 13:2575

    Article  CAS  PubMed  Google Scholar 

  • Vardabasso C, Hasson D, Ratnakumar K, Chung CY, Duarte LF, Bernstein E (2014) Histone variants: emerging players in cancer biology. Cell Mol Life Sci 71:379–404

    Article  CAS  PubMed  Google Scholar 

  • Volk A, Liang K, Suraneni P, Li X, Zhao J, Bulic M, Marshall S, Pulakanti K, Malinge S, Taub J, Ge Y, Rao S, Bartom E, Shilatifard A, Crispino JD (2018) A CHAF1B-dependent molecular switch in hematopoiesis and leukemia pathogenesis. Cancer Cell 34:707–723.e707

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wen T, Chen QY (2022) Dynamic activity of histone H3-specific chaperone complexes in oncogenesis. Front Oncol 11:806974

    Article  PubMed  PubMed Central  Google Scholar 

  • Wu Y, Li X, Yu J, Björkholm M, Xu D (2019) ASF1a inhibition induces p53-dependent growth arrest and senescence of cancer cells. Cell Death Dis 10:76

    Article  PubMed  PubMed Central  Google Scholar 

  • Yang S, Long Q, Chen M, Liu X, Zhou H (2020a) CAF-1/p150 promotes cell proliferation, migration, invasion and predicts a poor prognosis in patients with cervical cancer. Oncol Lett 20:2338–2346

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yang L, Wang X, Jiao X, Tian B, Zhang M, Zhou C, Wang R, Chen H, Wang B, Li J, Liu J, Zhang G, Liu P (2020b) Suppressor of ty 16 promotes lung cancer malignancy and is negatively regulated by miR-1227-5p. Cancer Sci 111:4075–4087

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yang S, Zhu XN, Zhang HL, Yang Q, Wei YS, Zhu D, Liu MD, Shen SM, Xia L, He P, Ge MK, Pan YL, Zhao M, Wu YL, Zheng JK, Chen GQ, Yu Y (2021) ANP32B-mediated repression of p53 contributes to maintenance of normal and CML stem cells. Blood 138:2485–2498

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yoo C, Jones P (2006) Epigenetic therapy of cancer: past, present and future. Nat Rev Drug Discov 5:37–50

    Article  CAS  PubMed  Google Scholar 

  • Zhai W, Ma J, Zhu R, Xu C, Zhang J, Chen Y, Chen Z, Gong D, Zheng J, Chen C, Li S, Li B, Huang Y, Xue W, Zheng J (2018) MiR-532-5p suppresses renal cancer cell proliferation by disrupting the ETS1-mediated positive feedback loop with the KRAS-NAP1L1/P-ERK axis. Br J Cancer 119:591–604

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhang YW, Chen Q, Li B, Li HY, Zhao XK, Xiao YY, Liu S, Zuo S (2021a) NAP1L1 functions as a tumor promoter via recruiting hepatoma derived growth factor/c-Jun signal in hepatocellular carcinoma. Front Cell Dev Biol 9:659680

    Google Scholar 

  • Zhang W, Gao Z, Guan M, Liu N, Meng F, Wang G (2021b) ASF1B promotes oncogenesis in lung adenocarcinoma and other cancer types. Front Oncol 11:731547

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhang S, Xu L, Feng J, Tan D, Zhu Y, Hou J, Li W, Lv K, Wang W, Jiang L, Jiao M, Guo H (2022) ASF1B is a promising prognostic biomarker and correlates with immunotherapy efficacy in hepatocellular carcinoma. Front Genet 13:842351

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhu Z, Li C, Zeng Y, Ding J, Qu Z, Gu J, Ge L, Tang F, Huang X, Zhou C, Wang P, Zheng D, Jin Y (2017) PHB associates with the HIRA complex to control an epigenetic-metabolic circuit in human ESCs. Cell Stem Cell 20:274–289.e7

    Article  CAS  PubMed  Google Scholar 

  • Zhu X, Xie Y, Huang W, Chen Z, Guo S (2022) NAP1L1 promotes tumor proliferation through HDGF/C-JUN signaling in ovarian cancer. BMC Cancer 22:339

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Regenerative Biology Program, Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram, Kerala, India

    Mayur Balkrishna Shirude & Debasree Dutta

  2. Manipal Academy of Higher Education, Manipal, Karnataka, India

    Mayur Balkrishna Shirude

Authors
  1. Mayur Balkrishna Shirude
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Debasree Dutta
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Debasree Dutta .

Editor information

Editors and Affiliations

  1. Dept. Biotechnology, Panjab University, Chandigarh, Chandigarh, India

    R. C. Sobti

  2. NCR Biotech Science Cluster, Translational Health Sci & Tech Inst, Faridabad, Haryana, India

    Nirmal K. Ganguly

  3. Cancer Research Institute, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, Uttarakhand, India

    Rakesh Kumar

Section Editor information

  1. Department of Biotechnology, Thapar Institute of Engineering and Technology, Patiala, India

    Siddharth Sharma

Rights and permissions

Reprints and permissions

Copyright information

© 2024 Springer Nature Singapore Pte Ltd.

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Shirude, M.B., Dutta, D. (2024). Histone Chaperones in Cancer. In: Sobti, R.C., Ganguly, N.K., Kumar, R. (eds) Handbook of Oncobiology: From Basic to Clinical Sciences. Springer, Singapore. https://doi.org/10.1007/978-981-99-2196-6_39-2

Download citation

  • DOI: https://doi.org/10.1007/978-981-99-2196-6_39-2

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-99-2196-6

  • Online ISBN: 978-981-99-2196-6

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics

Chapter history

  1. Latest

    Histone Chaperones in Cancer
    Published:
    28 September 2023

    DOI: https://doi.org/10.1007/978-981-99-2196-6_39-2

  2. Original

    Histone Chaperones in Cancer
    Published:
    07 August 2023

    DOI: https://doi.org/10.1007/978-981-99-2196-6_39-1

Search

Navigation