Recent Progress in Hypoxia-Targeting: Peptide-Based Nanomaterials

Kumari, Pooja; Sharma, Preeti; Srivastava, Yogesh; Sharma, Narendra Kumar

doi:10.1007/978-981-99-1718-1_4

Pooja Kumari⁶,
Preeti Sharma⁶,
Yogesh Srivastava⁷ &
…
Narendra Kumar Sharma⁶

Part of the book series: Smart Nanomaterials Technology ((SNT))

135 Accesses

Abstract

Hypoxia is a common symptom of many serious disorders, including cancer, ischemic strokes, and rheumatoid arthritis. It is a natural physiologic barrier seen in the microenvironment of solid tumors that has significantly restricted the therapeutic impact of photodynamic treatment (PDT). For oxygen-consumption photodynamic treatment (PDT), local hypoxia is an unfavorable obstacle in tumors. Angiogenesis, invasion, metastasis, and chemotherapy resistance are all affected by a shortage of oxygen. Furthermore, PDT has the possibility of aggravating hypoxia. Meanwhile, the troublesome aggregation-caused quenching effect affects the photosensitizer (PS) compounds utilized in PDT applications and dramatically reduces the efficiency with which deadly reactive oxygen species are produced. Over recent decades, hypoxia's potential as a therapeutic target has become more widely recognized. Because of their benefits in safety, target specificity, and tumor penetrability, peptides have been intensively explored to treat these disease conditions. Low drug/energy delivery effectiveness, drug resistance brought on by hypoxia, and tumor nonspecificity can all be mitigated using peptides. Three basic methods have recently been applied to use peptide-based nanomaterials to target hypoxia: (i) using hypoxic microenvironment-sensitive peptide linkers that could be split to liberate medicinal payloads; (ii) the merger foregoing, in which earmarks peptides to direct the system to hypoxic surroundings, allowing for selective cleavage; and (iii) target cellular environments using peptide ligands that are particular for a hypoxic environment, such as receptors of the cell surface that are upregulated. In this paper, we go over the advantages and limitations of using peptide-based hypoxia-targeting nanomaterials in a variety of therapeutic situations.

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Abbreviations

PEG:: Polyethylene Glycol
H₂O₂:: Hydrogen Peroxide
DOX:: Doxorubicin
CC:: Cytochrome
O₂:: Oxygen
SR:: Singlet Oxygen Responsive
AVT-NP:: Angiogenesis Vessel Targeting Nanoparticle
TPC:: Tris Phenyl Chlorine
TG₂:: Transglutaminase
ELPs:: Elastin-Like polypeptides
PLA:: Polylactic Acid
PGA:: Polyglycolic Acid
PLGA:: Polylactic Acid Glycolic Acid
PCL:: Polycaprolactone
DA:: Dimethylmaleic Anhydride
ROS:: Reactive Oxygen Species
PFOB:: Perfluorooctyl Bromide
HPAO:: Hydroxyphenyl Propionic Acid-OSu
SPECT:: Single Photon Emission Computed Tomography
NPs:: Nanoparticles
DSPC:: Distearoyl-Sn Glycero-3-Phosphocholine
POPE:: Palmitoyl Oleoyl phosphatidylethanolamine
CRT:: Calreticulin
EPR:: Enhanced Permeability and Retention
NADs:: Nitrobenzyl Alcohol Derivatives
PDT:: Photodynamic Therapy
NI:: Nitro Imidazole
AZR:: Azoreductase
NA:: Nitrobenzyl Alcohol
AZO:: Azobenzene

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Department of Bioscience and Biotechnology, Banasthali Vidyapith, Tonk, Rajasthan, 304022, India
Pooja Kumari, Preeti Sharma & Narendra Kumar Sharma
Department of Genetics, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA
Yogesh Srivastava

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Pooja Kumari
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Preeti Sharma
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Yogesh Srivastava
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Narendra Kumar Sharma
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Correspondence to Narendra Kumar Sharma .

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Department of Biotechnology, Jaypee Institute of Information Technology, Noida, Uttar Pradesh, India
Sonam Chawla
Department of Biotechnology, Sankalchand Patel University, Visnagar, Gujarat, India
Sachidanand Singh
Wolaita Sodo University, Wolaita, Ethiopia
Azamal Husen

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Kumari, P., Sharma, P., Srivastava, Y., Sharma, N.K. (2023). Recent Progress in Hypoxia-Targeting: Peptide-Based Nanomaterials. In: Chawla, S., Singh, S., Husen, A. (eds) Smart Nanomaterials Targeting Pathological Hypoxia. Smart Nanomaterials Technology. Springer, Singapore. https://doi.org/10.1007/978-981-99-1718-1_4

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DOI: https://doi.org/10.1007/978-981-99-1718-1_4
Published: 30 June 2023
Publisher Name: Springer, Singapore
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Online ISBN: 978-981-99-1718-1
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