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Effects of Exercise on Circulating Extracellular Vesicles in Cardiovascular Disease

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Extracellular Vesicles in Cardiovascular and Metabolic Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1418))

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Abstract

The evidence that physical exercise has multiple beneficial effects and is essential to a healthy lifestyle is widely accepted for a long-time. The functional and psychological changes promoted by exercise improve clinical outcomes and prognosis in several diseases, by decreasing mortality, disease severity, and hospital admissions. Nonetheless, the mechanisms that regulate the release, uptake, and communication of several factors in response to exercise are still not well defined. In the last years, extracellular vesicles have attracted significant interest in the scientific community due to their ability to carry and deliver proteins, lipids, and miRNA to distant organs in the body, promoting a very exciting crosstalk machinery. Moreover, increasing evidence suggests that exercise can modulate the release of those factors within EVs into the circulation, mediating its systemic adaptations.

In this chapter, we summarize the effects of acute and chronic exercise on the extracellular vesicle dynamics in healthy subjects and patients with cardiovascular disease. The understanding of the changes in the cargo and kinetics of extracellular vesicles in response to exercise may open new possibilities of research and encourage the development of novel therapies that mimic the effects of exercise.

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Acknowledgements

Manuel Teixeira (2020.08565.BD), Tânia Soares Martins (SFRH/BD/145979/2019), and Marisol Gouveia (SFRH/BD/128893/2017) are supported by individual Ph.D. grants from Fundação para a Ciência e a Tecnologia (FCT, Portuguese Foundation for Science and Technology). iBiMED is a research unit supported by the Portuguese Foundation for Science and Technology (UID/BIM/04501/2020) and FEDER/Compete2020 funds.

This work was supported by a grant from FCT [PTDC/MEC- CAR/30011/2017] and co-financed by the FEDER under the new Partnership Agreement PT2020 within the project POCI- 01-0145-FEDER-030011.

Competing Financial Interests

The authors declare no competing financial interests.

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Authors and Affiliations

  1. Department of Medical Sciences, Institute of Biomedicine—iBiMED, University of Aveiro, Aveiro, Portugal

    Manuel Teixeira & Marisol Gouveia

  2. Department of Medical Sciences, Neurosciences and Signalling Group, Institute of Biomedicine—iBiMED, University of Aveiro, Aveiro, Portugal

    Tânia Soares Martins & Ana Gabriela Henriques

  3. Cardiology Service, Hospital Santo António, Centro Hospitalar Universitário do Porto, and Unit for Multidisciplinary Research In Biomedicine (UMIB), Institute of Biomedical Sciences Abel Salazar, University of Porto, Porto, Portugal

    Mário Santos

  4. Institute of Biomedicine—iBiMED, School of Health Sciences, University of Aveiro, Aveiro, Portugal

    Fernando Ribeiro

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  1. Manuel Teixeira
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Correspondence to Fernando Ribeiro .

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  1. Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Life Science, Shanghai University, Shanghai, China

    Junjie Xiao

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Teixeira, M., Martins, T.S., Gouveia, M., Henriques, A.G., Santos, M., Ribeiro, F. (2023). Effects of Exercise on Circulating Extracellular Vesicles in Cardiovascular Disease. In: Xiao, J. (eds) Extracellular Vesicles in Cardiovascular and Metabolic Diseases. Advances in Experimental Medicine and Biology, vol 1418. Springer, Singapore. https://doi.org/10.1007/978-981-99-1443-2_16

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