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Physiological Changes in the Local Onco-Sphere: Angiogenesis

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Tumor Ecosystem

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Abstract

Angiogenesis plays a critical role in the growth of cancer as tumors consistently require ample blood supply, especially during their exponential growth phase. Tumors will activate angiogenesis pathways through secretion of chemokines and cytokines if they are to grow beyond a few millimeters in size. In this chapter, we will focus on the importance of tumor in initiating angiogenesis in the local onco-sphere, and how angiogenesis also encourages cancer metastasis.

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  1. Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

    Phei Er Saw & Erwei Song

  2. Nanhai Translational Innovation Center of Precision Immunology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Foshan, China

    Phei Er Saw & Erwei Song

  3. Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

    Erwei Song

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  1. Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

    Erwei Song

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Saw, P.E., Song, E. (2023). Physiological Changes in the Local Onco-Sphere: Angiogenesis. In: Song, E. (eds) Tumor Ecosystem. Springer, Singapore. https://doi.org/10.1007/978-981-99-1183-7_6

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