Abstract
The COVID-19 pandemic posed a significant challenge to the global organization of health systems. The reallocation and concentration of available resources on the management of COVID-19 had a significant impact on all other health conditions due to the suspension or cancellation of screening and routine examinations, the reduction of referrals, and the redistribution of staff. The management of central disorders of hypersomnolence was also negatively affected, although some evidence has debated the role of the pandemic, which may have represented not only a challenge but also an opportunity for people with central disorders of hypersomnolence. On the one hand, the loss of zeitgebers as a result of changes in patients’ routines during the lockdown period, such as working from home, spending extended periods indoors, and a reduction in social interactions, could have worsened the management of these disorders. On the other hand, prolonged home confinement during the pandemic may have afforded more opportunities to implement the recommended behavioral strategies for reducing excessive daytime sleepiness and maintaining a more flexible sleep schedule. Consequently, the purpose of this chapter is to describe the most significant findings from studies examining the impact of the COVID-19 pandemic on central sleep disorders, with a particular emphasis on narcolepsy.
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References
Al-Quteimat OM, Amer AM (2020) The impact of the COVID-19 pandemic on cancer patients. Am J Clin Oncol Cancer Clin Trials 43(6):452–455
American Academy of Sleep Medicine (2021) COVID-19 mitigation strategies for sleep clinics & centers - REOPENING. https://aasm.org/covid-19-resources/covid-19-mitigation-strategies-sleep-clinics-labs/
Barateau L, Lopez R, Chenini S, Pesenti C, Rassu AL, Jaussent I et al (2020) Depression and suicidal thoughts in untreated and treated narcolepsy: systematic analysis. Neurology 95(20):E2755–E2768
Barateau L, Chenini S, Rassu AL, Denis C, Lorber Q, Dhalluin C, Lopez R, Jaussent I, Beziat S, Dauvilliers Y (2022) Changes in sleep pattern during the COVID-19 lockdown in patients with narcolepsy, idiopathic hypersomnia, and restless legs syndrome. Neurology 99(14):e1475–e1485
Bassetti CLA, Adamantidis A, Burdakov D, Han F, Gay S, Kallweit U et al (2019) Narcolepsy—clinical spectrum, aetiopathophysiology, diagnosis and treatment. Nat Rev Neurol 15(9):519–539
Cellini N, Canale N, Mioni G, Costa S (2020) Changes in sleep pattern, sense of time and digital media use during COVID-19 lockdown in Italy. J Sleep Res 29(4):1–5
CMS (2020) CMS releases recommendations on adult elective surgeries, non-essential medical, surgical, and dental procedures during COVID-19 response [Internet]. https://www.cms.gov/newsroom/press-releases/cms-releasesrecommendations-adult-elective-surgeries-non-essential-medical-surgicaland-dental
Dauvilliers Y, Paquereau J, Bastuji H, Drouot X, Weil JS, Viot-Blanc V (2009) Psychological health in central hypersomnias: the French Harmony study. J Neurol Neurosurg Psychiatry 80(6):636–641
Elmore SK, Betrus PA, Burr R (1994) Light, social zeitgebers, and the sleep–wake cycle in the entrainment of human circadian rhythms. Res Nurs Health 17(6):471–478
Fortuyn HA, Lappenschaar MA, Furer JW, Hodiamont PP, Rijnders CA, Renier WO, Buitelaar JK, Overeem S (2010) Anxiety and mood disorders in narcolepsy: a case-control study. Gen Hosp Psychiatry 32(1):49–54
Franceschini C, Musetti A, Zenesini C, Palagini L, Scarpelli S, Quattropani MC et al (2020) Poor sleep quality and its consequences on mental health during the COVID-19 lockdown in Italy. Front Psychol 11(November):1–15
Franceschini C, Pizza F, Cavalli F, Plazzi G (2021) A practical guide to the pharmacological and behavioral therapy of Narcolepsy. Neurotherapeutics 18(1):6–19. https://doi.org/10.1007/s13311-021-01051-4
Honma KI, Hashimoto S, Nakao M, Honma S (2003) Period and phase adjustments of human circadian rhythms in the real world. J Biol Rhythm 18(3):261–270
Izquierdo JL, Almonacid C, González Y, Del Rio-Bermudez C, Ancochea J, Cárdenas R et al (2021) The impact of COVID-19 on patients with asthma. Eur Respir J 57(3):2003142
Marčić M, Marčić L, Marčić B (2021) SARS-CoV-2 infection causes relapse of Kleine-Levin syndrome: case report and review of literature. Neurol Int 13(3):328–334
Morin CM, Bjorvatn B, Chung F, Holzinger B, Partinen M, Penzel T et al (2021) Insomnia, anxiety, and depression during the COVID-19 pandemic: an international collaborative study. Sleep Med 87:38–45
Morse A, Sanjeev K (2018) Narcolepsy and psychiatric disorders: comorbidities or shared pathophysiology? Med Sci 6(1):16
Motolese F, Rossi M, Albergo G, Stelitano D, Villanova M, Di Lazzaro V et al (2020) The psychological impact of COVID-19 pandemic on people with multiple sclerosis. Front Neurol 11(October):1–8
Nasrullah A, Javed A, Ashraf O, Malik K (2021) Possible role of COVID-19 in the relapse of Klein-Levin Syndrome. Respir Med Case Rep 33(March):101445. https://doi.org/10.1016/j.rmcr.2021.101445
Nigam M, Hippolyte A, Dodet P, Gales A, Maranci JB, Al-Youssef S et al (2022) Sleeping through a pandemic: impact of COVID-19-related restrictions on narcolepsy and idiopathic hypersomnia. J Clin Sleep Med 18(1):255–263
Nishino S, Ripley B, Overeem S, Nevsimalova S, Lammers GJ, Vankova J et al (2001) Low cerebrospinal fluid hypocretin (orexin) and altered energy homeostasis in human narcolepsy. Ann Neurol 50(3):381–388
Ozaki A, Inoue Y, Hayashida K, Nakajima T, Honda M, Usui A et al (2012) Quality of life in patients with narcolepsy with cataplexy, narcolepsy without cataplexy, and idiopathic hypersomnia without long sleep time: comparison between patients on psychostimulants, drug-naïve patients and the general Japanese population. Sleep Med 13(2):200–206. https://doi.org/10.1016/j.sleep.2011.07.014
Palagini L, Baglioni C, Ciapparelli A, Gemignani A, Riemann D (2013) REM sleep dysregulation in depression: state of the art. Sleep Med Rev 17(5):377–390. https://doi.org/10.1016/j.smrv.2012.11.001
Pizza F, Vignatelli L, Oriolo C, Zenesini C, Mangiaruga A, Rossetti A, Moresco M, Vandi S, Citeroni F, Pagotto U, Ingravallo F, Plazzi G (2022) Multidisciplinary care of patients with narcolepsy during COVID-19 pandemic in Italy via televisit: the TElemedicine for NARcolepsy (TENAR) feasibility study. Sleep 45(12):zsac228
Plazzi G, Serra L, Ferri R (2008) Nocturnal aspects of narcolepsy with cataplexy. Sleep Med Rev 12(2):109–128
Postiglione E, Pizza F, Ingravallo F, Vignatelli L, Filardi M, Mangiaruga A et al (2021) Impact of COVID-19 pandemic lockdown on narcolepsy type 1 management. Brain Behav 11(1):1–8
Richards M, Anderson M, Carter P, Ebert BL, Mossialos E (2020) The impact of the COVID-19 pandemic on cancer care. Nat Cancer 1(6):565–567. https://doi.org/10.1038/s43018-020-0074-y
Rodrigues Aguilar AC, Frange C, Huebra L, Dias Gomes AC, Tufik S, Santos Coelho FM (2021) The effects of the COVID-19 pandemic on patients with narcolepsy. J Clin sleep Med 17(4):621–627
Sateia MJ (2014) International classification of sleep disorders-third edition highlights and modifications. Chest 146(5):1387–1394. https://doi.org/10.1378/chest.14-0970
Schmier J, Halpern MT (2004) Patient recall and recall bias of health state and health status. Expert Rev Pharmacoecon Outcomes Res 4(2):159–163
Schnell R (2012) Survey-Interviews. Methoden standardisierter Befragungen, 2nd edn. Survey-Interviews
Singh J, Badr MS, Diebert W, Epstein L, Hwang D, Karres V, Khosla S, Mims KN, Shamim-Uzzaman A, Kirsch D, Heald JL, McCann K (2015) American Academy of Sleep Medicine (AASM) position paper for the use of telemedicine for the diagnosis and treatment of sleep disorders. J Clin Sleep Med 11(10):1187–1198
Vignatelli L, Plazzi G, Peschechera F, Delaj L, D’Alessandro R (2011) A 5-year prospective cohort study on health-related quality of life in patients with narcolepsy. Sleep Med 12(1):19–23. https://doi.org/10.1016/j.sleep.2010.07.008
World Health Organization (2019) WHO guideline: recommendations on digital interventions for health system strengthening. WHO, Geneva
Wu M, Ren J, Li SX, Xue P, Su C, Zhou J (2021) Management of narcolepsy during COVID-19: a challenge or an opportunity? Sleep 44(2):1–3
Zhu N, Zhang D, Wang W, Li X, Yang B, Song J et al (2020) A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 382(8):727–733
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Varallo, G., Franceschini, C., Plazzi, G. (2023). What Happened to Central Disorders of Hypersomnolence During the COVID-19 Pandemic?. In: BaHammam, A., Pandi-Perumal, S.R., Jahrami, H. (eds) COVID-19 and Sleep: A Global Outlook. Progress in Sleep Research. Springer, Singapore. https://doi.org/10.1007/978-981-99-0240-8_15
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