Abstract
The decision needs to be made in a multidisciplinary clinical team. Paranasal sinus malignancies are rare aggressive tumors. Radiotherapy is an integral part of management either as a single modality or in combination. There is a wide range of histopathological entities in this subtype with varying radiation sensitivity. Local failure is the major pattern of relapse. Lymph nodal involvement is less frequent in nasal and paranasal sinus malignancies although in cases of nasopharyngeal cancers it is present in up to 90% of the cases. The advent of advanced technologies in the form of IMRT and particle therapy substantially improved the clinical outcome. Conformal treatment provides high rates of local control with decreased toxicities. Margin positivity and extracapsular spread in lymph nodes are the indications for chemotherapy.
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References
Allen MW, Schwartz DL, Rana V, et al. Long-term radiotherapy outcomes for nasal cavity and septal cancers. Int J Radiat Oncol Biol Phys. 2008;71:401–6.
Czerwinski MD, Van Leeuwen R, Kaanders J, Zwijnenburg EM, Lipman D, Takes RP, et al. Image guided brachytherapy for cancer of the nasal vestibule: local control and cosmesis. Int J Radiat Oncol Biol Phys. 2018;103:913–21.
Liang ZG, Kusumawidjaja G, Kazmi F, Wee JTS, Chua MLK. Intensity-modulated radiotherapy for paranasal sinuses and base of skull tumors. Oral Oncol. 2018;86:61–8.
Wang K, Zanation AM, Chera BS. The role of radiation therapy in the management of sinonasal and ventral skull base malignancies. Otolaryngol Clin N Am. 2017;50(2):419–32.
Chua DT, Sham JS, Kwong DL, et al. Treatment outcome after radiotherapy alone for patients with stage I-II nasopharyngeal carcinoma. Cancer. 2003;98:74–80.
Halperin EC, Brady LW, Wazer DE, Perez CA. Perez and Brady's principles and practice of radiation oncology. 7th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2018.
Lee NY, Lu JJ. Target volume delineation and field setup-a practical guide for conformal and intensity-modulated radiation therapy. Springer; 2015.
Yang Y, Zhu Y, Cao JZ, et al. Risk-adapted therapy for early-stage extranodal nasal-type NK/T-cell lymphoma: analysis from a multicenter study. Blood. 2015;126:1424–32.
Noronha V, Joshi A, Patil VM, Agarwal J, Ghosh-Laskar S, Budrukkar A, et al. Once-a-week versus once-every-3-weeks cisplatin chemoradiation for locally advanced head and neck cancer: a phase III Randomized Noninferiority Trial. J Clin Oncol Off J Am Soc Clin Oncol. 2018;36(11):1064–72.
Racadot S, Mercier M, Dussart S, Dessard-Diana B, Bensadoun R-J, Martin M, et al. Randomized clinical trial of post-operative radiotherapy versus concomitant carboplatin and radiotherapy for head and neck cancers with lymph node involvement. Radiother Oncol J Eur Soc Ther Radiol Oncol. 2008;87(2):164–72.
Patil VM, Noronha V, Joshi A, Agarwal J, Laskar SG, Budrukkar A, et al. Results of a randomized phase III study of nimotuzumab in combination with concurrent radiotherapy and cisplatin versus radiotherapy and cisplatin alone, in locally advanced squamous cell carcinoma of the head and neck. J Clin Oncol. 2018;36(15_suppl):6000.
Vermorken JB, Mesia R, Rivera F, Remenar E, Kawecki A, Rottey S, et al. Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med. 2008;359(11):1116–27.
Burtness B, Harrington KJ, Greil R, et al. Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study. Lancet. 2019;394:1915.
Ferris RL, Blumenschein G, Fayette J, Guigay J, Colevas AD, Licitra L, et al. Nivolumab for recurrent squamous-cell carcinoma of the head and neck. N Engl J Med. 2016;375(19):1856–67.
Patil VM, Noronha V, Joshi A, Pinninti R, Dhumal S, Bhattacharjee A, et al. Metronomic chemotherapy in platinum-insensitive failures and/or early failures postmultimodality management in oral cancers. Indian J Med Paediatr Oncol. 2015;36(3):161.
Zhang L, Huang Y, Hong S, Yang Y, Yu G, Jia J, et al. Gemcitabine plus cisplatin versus fluorouracil plus cisplatin in recurrent or metastatic nasopharyngeal carcinoma: a multicentre, randomised, open-label, phase 3 trial. Lancet Lond Engl. 2016;388(10054):1883–92.
Vermorken JB, Mesia R, Rivera F, et al. Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med. 2008;359:1116.
Soler ZM, Jones R, Le P, et al. Sino-nasal outcome test-22 outcomes after sinus surgery: a systematic review and meta-analysis. Laryngoscope. 2018;128(3):581–92.
Quintanilla-Dieck L, Litvack JR, Mace JC, Smith TL. Comparison of disease-specific quality-of-life instruments in the assessment of chronic rhinosinusitis. Int Forum Allergy Rhinol. 2012;2(6):437–43.
Lehrer-Coriat E, Mariño-Sánchez F, Alobid I, Mullol J. Quality of life measures in patients on rhinosinusitis trials. Clin Invest. 2013;3(3):251–63.
Levy JM, Mace JC, DeConde AS, Steele TO, Smith TL. Improvements in psychological dysfunction after endoscopic sinus surgery for patients with chronic rhinosinusitis. Int Forum Allergy Rhinol. 2016;6(9):906–13.
Alakarppa AI, Koskenkorva TJ, Koivunen PT, Alho O-P. Quality of life before and after sinonasal surgery: a population-based matched cohort study. Eur Arch Otorhinolaryngol. 2017;274:795–802.
Kohli P, Naik AN, Farhood Z, Ong AA, et al. Olfactory outcomes after endoscopic sinus surgery for chronic rhinosinusitis: a meta-analysis. Otolaryngol Head Neck Surg. 2016;155(6):936–48.
Bugten V, Nilsen AH, Thorstensen MW, Moxness MHS, et al. Quality of life and symptoms before and after nasal septoplasty compared with healthy individuals. BMC Ear Nose Throat Disord. 2016;16:13.
Alakärppä AI, Koskenkorva TJ, Koivunen PT, Alho O-P. Predictive factors of a beneficial quality of life outcome in patients undergoing primary sinonasal surgery: a population-based prospective cohort study. Eur Arch Otorhinolaryngol. 2018;275:1139–47.
Le PT, Soler ZM, Jones R, Mattos JL, et al. Systematic review and meta-analysis of SNOT-22 outcomes after surgery for chronic rhinosinusitis with nasal polyposis. Otolaryngol Head Neck Surg. 2018;159(3):414–23.
Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, et al. Clinical practice guideline (update): adult sinusitis. Otolaryngol Head Neck Surg. 2015;152(2S):S1–S39.
Tsuzuki K, Hashimoto K, Okazaki K, et al. Post-operative course prediction during endoscopic sinus surgery in patients with chronic rhinosinusitis. J Laryngol Otol. 2018;132:408–17.
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Devnani, B., Bhasker, S., Pramanik, R., Vadlamani, S.P., Mani, S. (2021). Radiotherapy, Chemotherapy, and Quality of Life. In: Verma, H., Thakar, A. (eds) Essentials of Rhinology. Springer, Singapore. https://doi.org/10.1007/978-981-33-6284-0_10
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