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Human Diseases Induced by Oxidative Damage in DNA

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Nucleic Acid Biology and its Application in Human Diseases

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Abstract

Reactive oxygen and nitrogen species (RONS) can be produced in our system by several endogenous and exogenous processes, leading toward the accumulation of oxidative lesions throughout the genome. Oxidative DNA damage is a major threat to genomic integrity, thus resulting in the manifestation of various chronic diseases including cancer, cardiovascular disorders, and neurodegeneration. 7,8-dihydro-8oxo-deoxyguanine (8-oxo-G) is one of the best characterized oxidative DNA lesions. If not repaired, A:8-oxo-G mispairs can give rise to C: G → A: T transversion mutations. These lesions are mainly repaired by BER and NER pathways, which are regulated by an arsenal of different proteins at different levels. In this chapter, we briefly detail the generation of oxidative DNA damage and the effects of this damage in cellular level. We also highlighted the possible repair pathways to erase these lesions and discussed all the human diseases induced by this oxidative DNA damage.

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Authors and Affiliations

  1. Department of Biophysics, Bose Institute, Kolkata, West Bengal, India

    Suman Panda, Oishika Chatterjee & Subhrangsu Chatterjee

  2. Barasat Cancer Research and Welfare Centre, Kolkata, West Bengal, India

    Gopeswar Mukherjee

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  1. Suman Panda
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  2. Oishika Chatterjee
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  4. Subhrangsu Chatterjee
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  1. Department of Biophysics, Bose Institute, Kolkata, West Bengal, India

    Subhrangsu Chatterjee

  2. Department of Biological Sciences, Birla Institute of Technology and Science, Zuarinagar, Goa, India

    Samit Chattopadhyay

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Panda, S., Chatterjee, O., Mukherjee, G., Chatterjee, S. (2023). Human Diseases Induced by Oxidative Damage in DNA. In: Chatterjee, S., Chattopadhyay, S. (eds) Nucleic Acid Biology and its Application in Human Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-19-8520-1_5

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