Abstract
Infantile hemangiomas (IH) are the most common benign vascular tumors of infancy, and they can present as small isolated lesions to large masses with segmental involvement anywhere on the body. Depending on the location and size of the IH, complications can arise ranging from ulceration to vital functional impairment to poor cosmesis upon regression. Due to the prevalence and significant ocular complications associated with periocular infantile hemangiomas, a thorough understanding of the natural history, clinical presentations, treatment, and complications will be valuable for ophthalmologists who will be encountering these cases. This chapter will review the epidemiology, pathogenesis, clinical manifestations, diagnosis, and latest updates on the management of patients with periocular IH [1].
Aparna Ramasubramanian, M.D. has had full access to all the data in the study and takes responsibility for the integrity of the data.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Tavakoli M, Yadegari S, Mosallaei M, Aletaha M, Salour H, Lee WW. Infantile periocular hemangioma. J Ophthalmic Vis Res. 2017;12(2):205–11. https://doi.org/10.4103/jovr.jovr_66_17.
Zhao J, Huang AH, Rainer BM, et al. Periocular infantile hemangiomas: characteristics, ocular sequelae, and outcomes. Pediatr Dermatol. 2019;36(6):830–4. https://doi.org/10.1111/pde.13925.
Haggstrom AN, Drolet BA, Hemangioma Investigator Group, et al. Prospective study of infantile hemangiomas: demographic, prenatal, and perinatal characteristics. J Pediatr. 2007;150(3):291–4. https://doi.org/10.1016/j.jpeds.2006.12.003.
Chiller KG, Passaro D, Frieden IJ. Hemangiomas of infancy: clinical characteristics, morphologic subtypes, and their relationship to race, ethnicity, and sex. Arch Dermatol. 2002;138(12):1567–76. https://doi.org/10.1001/archderm.138.12.1567.
Drolet BA, Esterly NB, Frieden IJ. Hemangiomas in children. N Engl J Med. 1999;341(3):173–81. https://doi.org/10.1056/NEJM199907153410307.
Garzon MC, Drolet BA, Baselga E, et al. Comparison of infantile hemangiomas in preterm and term infants: a prospective study. Arch Dermatol. 2008;144(9):1231–2. https://doi.org/10.1001/archderm.144.9.1231.
Men CJ, Ediriwickrema LS, Paik JS, et al. Surgical intervention of periocular infantile hemangiomas in the era of β-blockers. Ophthalmic Plast Reconstr Surg. 2020;36(1):70–3. https://doi.org/10.1097/IOP.0000000000001466.
Leon-Villapalos J, Wolfe K, Kangesu L. GLUT-1: an extra diagnostic tool to differentiate between haemangiomas and vascular malformations. Br J Plast Surg. 2005;58(3):348–52.
Barnés CM, Huang S, Kaipainen A, Sanoudou D, Chen EJ, Eichler GS, Guo Y, Yu Y, Ingber DE, Mulliken JB, Beggs AH, Folkman J, Fishman SJ. Evidence by molecular profiling for a placental origin of infantile hemangioma. Proc Natl Acad Sci U S A. 2005;102(52):19097–102.
Takahashi K, Mulliken JB, Kozakewich HP, et al. Cellular markers that distinguish the phases of hemangioma during infancy and childhood. J Clin Invest. 1994;93:2357–64.
Spence-Shishido AA, Good WV, Baselga E, Frieden IJ. Hemangiomas and the eye. Clin Dermatol. 2015;33(2):170–82. https://doi.org/10.1016/j.clindermatol.2014.10.009.
Tollefson MM, Frieden IJ. Early growth of infantile hemangiomas: what parents’ photographs tell us. Pediatrics. 2012;130(2):e314–20. https://doi.org/10.1542/peds.2011-3683.
Baselga E, Roe E, Coulie J, et al. Risk factors for degree and type of Sequelae after involution of untreated Hemangiomas of infancy. JAMA Dermatol. 2016;152(11):1239–43. https://doi.org/10.1001/jamadermatol.2016.2905.
Chang LC, Haggstrom AN, Drolet BA, et al. Growth characteristics of infantile hemangiomas: implications for management. Pediatrics. 2008;122(2):360–7. https://doi.org/10.1542/peds.2007-2767.
Samuelov L, Kinori M, Mancini AJ, et al. Ocular complications in PHACE syndrome: a true association or a coincidence? J Pediatr. 2019;204:214–218.e2. https://doi.org/10.1016/j.jpeds.2018.08.031.
Darrow DH, Greene AK, Mancini AJ, et al. Diagnosis and management of infantile hemangioma. Pediatrics. 2015;136(4):e1060–104. https://doi.org/10.1542/peds.2015-2485.
Krowchuk DP, Frieden IJ, Mancini AJ, et al. Clinical practice guideline for the management of infantile hemangiomas. Pediatrics. 2019;143(1):e20183475. https://doi.org/10.1542/peds.2018-3475.
Hutchinson AK, Kraker RT, Pineles SL, VanderVeen DK, Wilson LB, Galvin JA, Lambert SR. The Use of β-Blockers for the Treatment of Periocular Hemangiomas in Infants: A Report by the American Academy of Ophthalmology. Ophthalmology. 2019;126(1):146–155.
Acknowledgment
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2022 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Somisetty, S., Montoya, L., Price, H., Ramasubramanian, A. (2022). Periocular Infantile Hemangiomas. In: Ramasubramanian, A. (eds) Pediatric Ophthalmology. Current Practices in Ophthalmology. Springer, Singapore. https://doi.org/10.1007/978-981-19-4963-0_6
Download citation
DOI: https://doi.org/10.1007/978-981-19-4963-0_6
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-19-4962-3
Online ISBN: 978-981-19-4963-0
eBook Packages: MedicineMedicine (R0)