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Eye Complications Following COVID-19

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Post COVID-19 Complications and Management
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Abstract

As the pandemic has evolved and the knowledge of the coronavirus disease (COVID-19) has expanded, we have seen several ocular manifestations of this deadly virus. Besides the direct involvement of the ocular tissues by the virus, ocular manifestations have been seen due to opportunistic infections and body’s exaggerated autoimmune response.

Conjunctivitis is the most commonly reported ocular manifestation of this virus. This, along with the fact that ACE-2 receptors are present on the ocular surface, strengthens the hypothesis that the eye may act as a portal of entry for the virus. Intraocular features range from uveitis to vision-threatening retinal abnormalities like a central retinal vein or artery occlusion. The most severe form of eye involvement is rhino-orbital-cerebral mucormycosis with high mortality rates despite the treatment. Central nervous system involvement in COVID-19 may present with several neuro-ophthalmic features like optic neuritis, cranial neuropathy, disc edema, eye movement disorder, and pupillary abnormalities. The occurrence of stroke is also higher with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) than with any other virus leading to visual symptoms due to involvement along the posterior visual pathway. Based on the current evidence, this chapter outlines the important ocular manifestations related to COVID-19 infection.

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References

  1. Tisdale AK, Dinkin M, Chwalisz BK. Afferent and efferent neuro-ophthalmic complications of coronavirus disease 19. J Neuroophthalmol. 2021;41:154–65.

    Article  PubMed  Google Scholar 

  2. Dhiman R, Rakheja V, Saxena R. An ophthalmologist’s insight into the viral pandemics. J Optom. 2021;15(1):35–43. https://doi.org/10.1016/j.optom.2020.10.005.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Sen M, Honavar S, Sharma N, Sachdev M. COVID-19 and eye. Indian J Ophthalmol. 2021;69:488–509. https://doi.org/10.4103/ijo.IJO_297_21.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Sun L, Hymowitz M, Pomeranz HD. Eye protection for patients with COVID-19 undergoing prolonged prone-position ventilation. JAMA Ophthalmol. 2021;139:109–12. https://doi.org/10.1001/jamaophthalmol.2020.4988.

    Article  PubMed  Google Scholar 

  5. Singh AK, Singh R, Joshi SR, Misra A. Mucormycosis in COVID-19: a systematic review of cases reported worldwide and in India. Diabetes Metab Syndr. 2021;15(4):102146. https://doi.org/10.1016/j.dsx.2021.05.019.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Benito-Pascual B, Gegúndez JA, Díaz-Valle D, Arriola-Villalobos P, Carreño E, Culebras E, Rodríguez-Avial I, Benitez-Del-Castillo JM. Panuveitis and optic neuritis as a possible initial presentation of the novel coronavirus disease 2019 (COVID-19). Ocul Immunol Inflamm. 2020;28(6):922–5. https://doi.org/10.1080/09273948.2020.1792512.

    Article  CAS  PubMed  Google Scholar 

  7. Novi G, Rossi T, Pedemonte E, Saitta L, Rolla C, Roccatagliata L, Inglese M, Farinini D. Acute disseminated encephalomyelitis after SARS-CoV-2 infection. Neurol Neuroimmunol Neuroinflamm. 2020;7(5):e797. https://doi.org/10.1212/NXI.0000000000000797.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Dinkin M, Gao V, Kahan J, Bobker S, Simonetto M, Wechsler P, Harpe J, Greer C, Mints G, Salama G, Tsiouris AJ, Leifer D. COVID-19 presenting with ophthalmoparesis from cranial nerve palsy. Neurology. 2020;95(5):221–3. https://doi.org/10.1212/WNL.0000000000009700.

    Article  CAS  PubMed  Google Scholar 

  9. Gutierrez-Ortiz C, Mendez A, Rodrigo-Rey S, et al. Miller Fisher syndrome and polyneuritis cranialis in COVID-19. Neurology. 2020;95(5):e601–1212.

    Article  CAS  PubMed  Google Scholar 

  10. Ghosh R, Lahiri D, Dubey S, Ray BK, Benito-León J. Hallucinatory palinopsia in COVID-19-induced posterior reversible encephalopathy syndrome. J Neuroophthalmol. 2020;40(4):523–6. https://doi.org/10.1097/WNO.0000000000001135.

    Article  PubMed  Google Scholar 

  11. Clarke KM, Riga V, Shirodkar AL, et al. Proning related bilateral anterior ischaemic optic neuropathy in a patient with COVID-19 related acute respiratory distress syndrome. BMC Ophthalmol. 2021;21:276. https://doi.org/10.1186/s12886-021-02028-9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Luther R, Skeoch S, Pauling JD, Curd C, Woodgate F, Tansley S. Increased number of cases of giant cell arteritis and higher rates of ophthalmic involvement during the era of COVID-19. Rheumatol Adv Pract. 2020;4(2):rkaa067. https://doi.org/10.1093/rap/rkaa067.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Ishaq H, Durrani T, Umar Z, Khan N, McCombe P, Ul Haq MA. Post-COVID opsoclonus myoclonus syndrome: a case report from Pakistan. Front Neurol. 2021;12:672524.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Pereira Coutinho M, Faustino P, Lourenço J, Leitão L. Acquired pendular nystagmus in the setting of COVID-19. Eur J Neurol. 2021;28(Suppl 1):767.

    Google Scholar 

  15. Kaya Tutar N, Kale N, Tugcu B. Adie-Holmes syndrome associated with COVID-19 ınfection. Indian J Ophthalmol. 2021;69(3):773–4.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Maleki A, Look-Why S, Manhapra A, Foster CS. COVID-19 recombinant mRNA vaccines and serious ocular inflammatory side effects: real or coincidence? J Ophthalmic Vis Res. 2021;16(3):490–501.

    PubMed  PubMed Central  Google Scholar 

  17. Alvarez LM, Neo YN, Davagnanam I, Ashenhurst M, Acheson J, Abdel-Hay A, et al. Post vaccination optic neuritis: observations from the SARS-CoV-2 pandemic. SSRN Electron J. https://doi.org/10.2139/ssrn.3889990.

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Saxena, R., Dhiman, R. (2022). Eye Complications Following COVID-19. In: Mohan, A., Mittal, S. (eds) Post COVID-19 Complications and Management. Springer, Singapore. https://doi.org/10.1007/978-981-19-4407-9_13

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  • DOI: https://doi.org/10.1007/978-981-19-4407-9_13

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-19-4406-2

  • Online ISBN: 978-981-19-4407-9

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